Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Denis J. Wakeham"'
Autor:
Tiffany L. Brazile, James P. MacNamara, Denis J. Wakeham, Mitchel Samels, Christopher M. Hearon, Jr., Benjamin D. Levine, Satyam Sarma
Publikováno v:
American Journal of Preventive Cardiology, Vol 15, Iss , Pp 100568- (2023)
Therapeutic Area: ASCVD/CVD in Women Background: As women age, structural and functional changes occur in the cardiovascular system that may predispose them to specific cardiovascular diseases. Heart failure with preserved ejection fraction (HFpEF) a
Externí odkaz:
https://doaj.org/article/68cdf7f0d3444f49b702a518df5550f1
Autor:
James M. Otto, James O.M. Plumb, Eleri Clissold, Shriya B. Kumar, Denis J. Wakeham, Walter Schmidt, Michael P.W. Grocott, Toby Richards, Hugh E. Montgomery
Publikováno v:
Haematologica, Vol 102, Iss 9 (2017)
In practice, clinicians generally consider anemia (circulating hemoglobin concentration < 120 g.l−1 in non-pregnant females and < 130 g.l−1 in males) as due to impaired hemoglobin synthesis or increased erythrocyte loss or destruction. Rarely is
Externí odkaz:
https://doaj.org/article/f07b81819b9541f4971985675820a17d
Autor:
Bryce N. Balmain, Andrew R. Tomlinson, James P. MacNamara, Linda S. Hynan, Denis J. Wakeham, Benjamin D. Levine, Satyam Sarma, Tony G. Babb
Publikováno v:
Chest.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0fa07394067b39918b46a071d057b91
https://doi.org/10.1016/j.chest.2023.04.003
https://doi.org/10.1016/j.chest.2023.04.003
Autor:
Satyam Sarma, James P. MacNamara, Bryce N. Balmain, Christopher M. Hearon, Denis J. Wakeham, Andrew R. Tomlinson, Linda S. Hynan, Tony G. Babb, Benjamin D. Levine
Publikováno v:
Circulation.
Background: Exercise intolerance is a defining characteristic of heart failure with preserved ejection fraction (HFpEF). A marked rise in pulmonary capillary wedge pressure (PCWP) during exertion is pathognomonic for HFpEF and is thought to be a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b14107590bef4aaf92e65bd02c40a5
https://pubmed.ncbi.nlm.nih.gov/36524474
https://pubmed.ncbi.nlm.nih.gov/36524474
Autor:
Denis J. Wakeham, Jack S. Talbot, Tony G. Dawkins, Rachel Lord, Freya M. Lodge, Bryony A. Curry, Christopher J. A. Pugh, Megan Lindsay Brown
Publikováno v:
Experimental Physiology. 105:1396-1407
What is the central question of this study? Carotid artery peak circumferential strain (PCS) and strain rate attenuate with age, but appear to be modulated by cardiorespiratory fitness status in young males. However, the relationship between habitual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6e2b3470e3e4de05b01fac0bf27598
https://doi.org/10.1113/ep088384
https://doi.org/10.1113/ep088384
Autor:
Seamus B Hughes, Denis J Wakeham, James P Macnamara, Bryce Balmain, Christopher Hearon, Tony Babb, Benjamin D Levine, Satyam Sarma
Publikováno v:
Circulation. 144
Introduction: Impaired stroke volume (SV) response during exercise is common in HFpEF. The regulation of SV during low intensity exercise is dependent on end-diastolic volume (EDV) reserve from a compliant left ventricle (LV). The Dynamic Starling Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19d1f0139d5bc0557fa07dc0886e252e
https://doi.org/10.1161/circ.144.suppl_1.13543
https://doi.org/10.1161/circ.144.suppl_1.13543
Autor:
Ryan L. Hoiland, Hannah G. Caldwell, Jay M. J. R. Carr, Connor A. Howe, Benjamin S. Stacey, Tony Dawkins, Denis J. Wakeham, Joshua C. Tremblay, Michael M. Tymko, Alexander Patrician, Kurt J. Smith, Mypinder S. Sekhon, David B. MacLeod, Daniel J. Green, Damian M. Bailey, Philip N. Ainslie
Publikováno v:
The Journal of physiologyReferences. 600(6)
Cerebrovascular CO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0005a903f875bd097f05f553e07225
https://pubmed.ncbi.nlm.nih.gov/34904229
https://pubmed.ncbi.nlm.nih.gov/34904229
Autor:
Alexander Patrician, Geoff B. Coombs, Joshua C. Tremblay, Daria A. Shkredova, Jay M. J. R. Carr, Denis J. Wakeham, Philip N. Ainslie
Publikováno v:
Journal of Applied Physiology, 130, 149-159
Journal of Applied Physiology, 130, 1, pp. 149-159
Journal of Applied Physiology, 130, 1, pp. 149-159
We measured acute vascular responses to heat stress to examine the hypothesis that macrovascular endothelial-dependent dilation is improved in a shear-dependent manner, which is further modified by skin temperature. Twelve healthy males performed who
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b09cba77761aaeb0712236bf99c2f7
https://pubmed.ncbi.nlm.nih.gov/33119469
https://pubmed.ncbi.nlm.nih.gov/33119469
Autor:
Freya M. Lodge, Jonathan P. Moore, Tony G. Dawkins, Christopher J. A. Pugh, Denis J. Wakeham, Rob E. Shave, Lydia L. Simpson, Bryony A. Curry, Jack S. Talbot, Rachel Lord
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 319(2)
We assessed the influence of barosensory vessel mechanics (magnitude and rate of unloading and time spent unloaded) as a surrogate for baroreceptor unloading. In young men, aortic unloading mechanics are important in regulating the operating point of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deec1bb0ad0c35f08f8b93671e27d28a
https://pubmed.ncbi.nlm.nih.gov/32648822
https://pubmed.ncbi.nlm.nih.gov/32648822
Autor:
Hugh Montgomery, Toby Richards, Walter Schmidt, Michael P.W. Grocott, Lisa Loughney, James M. Otto, Eleri Clissold, Denis J. Wakeham, James O. M. Plumb
Publikováno v:
British Journal of Anaesthesia. 118:747-754
Background Cardiopulmonary exercise testing (CPET) measures peak exertional oxygen consumption ( V ˙ O 2 peak ) and that at the anaerobic threshold ( V ˙ O 2 at AT, i.e. the point at which anaerobic metabolism contributes substantially to overall m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e879f3eab6f3d5facdc1a95a9a06abf2
https://doi.org/10.1093/bja/aew445
https://doi.org/10.1093/bja/aew445