Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Denis J Morgan"'
Publikováno v:
Canadian Journal of Gastroenterology, Vol 5, Iss 2, Pp 77-81 (1991)
A variety of tests has been used to assess liver function and predict hepatic functional reserve in patients with liver disease. These tests comprise clinical assessment, simple biochemical measurements and so-called ‘quantitative’ tests of liver
Externí odkaz:
https://doaj.org/article/f5d8c44d25564277af9750a37b5577bd
Autor:
Denis J. Morgan, Henri Tochon-Danguy, John I. Sachinidis, Andrew M. Scott, Peter W Angus, Paul R. Froomes, Michael S. Ching, Hany Ghabrial
Publikováno v:
Nuclear Medicine and Biology. 30:93-100
Measurement of hepatic sinusoidal permeability of oxygen and other substrates may help elucidate the mechanisms responsible for impaired liver function in cirrhosis. However studies of sinusoidal oxygen permeability in normal liver and various diseas
Autor:
Richard B Sewell, Michael S Nobes, Hany Ghabrial, Richard A. Smallwood, Katrina M Simms, Denis J. Morgan
Publikováno v:
Journal of Gastroenterology and Hepatology. 17:598-605
Background: In the erythrocytic phase of malaria, Kupffer cells show marked hypertrophy and hyperplasia and are filled with malarial pigment. However, phagocytic function in this state has not been well characterized. The aim of the present study was
Autor:
Stephen B. Kahl, Shannon Uren, Roger L. Nation, John S. Hill, Andrew H. Kaye, Michael D. Green, Bhadu Kavar, Howard Geldard, Denis J. Morgan, Mark Rosenthal, Stanley S. Stylli, Russell L. Basser
Publikováno v:
Journal of Clinical Oncology. 19:519-524
PURPOSE: To determine the recommended dose, toxicity profile, and pharmacokinetics of a novel boronated porphyrin (BOPP) for photodynamic therapy (PDT) of intracranial tumors. PATIENTS AND METHODS: BOPP was administered alone in increasing doses (0.2
Publikováno v:
Pharmacology & Toxicology. 88:3-15
After the transition from in utero to newborn life, the neonate becomes solely reliant upon its own drug clearance processes to metabolise xenobiotics. Whilst most studies of neonatal hepatic drug elimination have focussed upon in vitro expression an
Autor:
Denis J. Morgan, Michael S. Ching, Richard A. Smallwood, Arthur Shulkes, Paul J Gow, Saard Treepongkaruna, Hany Ghabrial
Publikováno v:
Journal of Pharmaceutical Sciences. 89:586-593
Using the isolated perfused neonatal sheep liver model, we examined the disposition of propranolol ( n = 8, age 0.25–10 days) and compared our findings with our previous study from the perfused near‐term fetal sheep liver (Ring JA, et al. 1995 .
Autor:
Michael S. Ching, Arthur Shulkes, Paul J Gow, Denis J. Morgan, Richard A. Smallwood, Hany Ghabrial, Saard Treepongkaruna
Publikováno v:
Journal of Pharmaceutical Sciences. 89:36-44
We examined the metabolism of para‐nitrophenol (PNP) in the isolated perfused neonatal sheep liver ( n = 8, 0.25–11 days) and compared the findings with our previous data from the perfused near‐term fetal sheep liver (Ring, J. A., et al. Drug M
Publikováno v:
Pharmacology & Therapeutics. 84:429-445
The majority of studies of fetal hepatic elimination have concentrated on the expression and activity of the metabolizing enzymes, but the unique physiologic milieu of the fetal liver should also be considered. The basic structure of the liver is for
Publikováno v:
Gastroenterology. 116:915-920
Background & Aims: Sinusoidal capillarization in cirrhosis may impair the transfer of oxygen into hepatocytes; this may contribute to impaired oxidative drug metabolism. The aim of this study was to test this hypothesis by comparing the effects of ox
Clonidine and Cardiac Surgery: Haemodynamic and Metabolic Effects, Myocardial Ischaemia and Recovery
Autor:
Mark Buckland, Michael Bujor, Donald S. Esmore, Paul S. Myles, Bruce B. Davis, J. L. Hall, Denis J. Morgan, Jennifer O. Hunt, John Moloney, H O Holdgaard, R. Mcrae
Publikováno v:
Europe PubMed Central
Clonidine may have beneficial effects in patients undergoing major surgery. We enrolled 156 patients having elective CABG surgery in a double-blind, randomized trial. Patients were randomized to receive either two doses of placebo (Group PP) or cloni