Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Denis I. Crane"'
Autor:
Yongjun Fan, Gautam Wali, Ratneswary Sutharsan, Bernadette Bellette, Denis I. Crane, Carolyn M. Sue, Alan Mackay-Sim
Publikováno v:
Biology Open, Vol 3, Iss 6, Pp 494-502 (2014)
Hereditary Spastic Paraplegia (HSP) is a genetically heterogeneous group of disorders, diagnosed by progressive gait disturbances with muscle weakness and spasticity, for which there are no treatments targeted at the underlying pathophysiology. Mutat
Externí odkaz:
https://doaj.org/article/0e25420270d44897989da33cb4a75dfe
Autor:
C. Catharina Müller, Tam H. Nguyen, Barbara Ahlemeyer, Mallika Meshram, Nishreen Santrampurwala, Siyu Cao, Peter Sharp, Pamela B. Fietz, Eveline Baumgart-Vogt, Denis I. Crane
Publikováno v:
Disease Models & Mechanisms, Vol 4, Iss 1, Pp 104-119 (2011)
SUMMARY Delayed cerebellar development is a hallmark of Zellweger syndrome (ZS), a severe neonatal neurodegenerative disorder. ZS is caused by mutations in PEX genes, such as PEX13, which encodes a protein required for import of proteins into the per
Externí odkaz:
https://doaj.org/article/5633aacc1f4d4ca1a76cfcc0e8cca5d4
Publikováno v:
The Scientific World Journal, Vol 2013 (2013)
Earlier findings from our laboratory implicated RhoA in heart developmental processes. To investigate factors that potentially regulate RhoA expression, RhoA gene organisation and promoter activity were analysed. Comparative analysis indicated strict
Externí odkaz:
https://doaj.org/article/2256c55771594abeb4ee03a2364f433b
Autor:
Eriza S. Secondes, Denis I. Crane, Michelle Melino, Maneet Bhatia, Gautam Rishi, V. Nathan Subramaniam
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1866(10)
Peroxisomes are organelles, abundant in the liver, involved in a variety of cellular functions, including fatty acid metabolism, plasmalogen synthesis and metabolism of reactive oxygen species. Several inherited disorders are associated with peroxiso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e006651ec19d5dbc565c3b9f9738f1
https://pubmed.ncbi.nlm.nih.gov/32565019
https://pubmed.ncbi.nlm.nih.gov/32565019
Publikováno v:
Disaster Prevention and Management: An International Journal. 27:447-455
Purpose The purpose of this paper is to reveal difficulties associated with identifying child victims of the 2004 South-East Asia Tsunami at the Thai Tsunami Victim Identification (TTVI) operation in Phuket and explores two strategies that increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::350b5358704c6de79ddaa77163a765ce
https://doi.org/10.1108/dpm-02-2018-0044
https://doi.org/10.1108/dpm-02-2018-0044
Autor:
Prashant Mishra, Shyam Sirasanagandla, Rhea Sumpter, Yongjie Wei, Beth Levine, Denis I. Crane, Ming Y Lee, Zhongju Zou, Hendrik Rosewich
Publikováno v:
EMBO Reports
PEX13 is an integral membrane protein on the peroxisome that regulates peroxisomal matrix protein import during peroxisome biogenesis. Mutations in PEX13 and other peroxin proteins are associated with Zellweger syndrome spectrum (ZSS) disorders, a su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28fadedff0e7963f8c382b687be9c23
http://europepmc.org/articles/PMC5210156
http://europepmc.org/articles/PMC5210156
Publikováno v:
Neuroscience. 334:201-213
Zellweger syndrome (ZS) is a peroxisome biogenesis disorder that involves significant neuropathology, the molecular basis of which is still poorly understood. Using a mouse model of ZS with brain-restricted deficiency of the peroxisome biogenesis pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1cbd70def86fe2eefe62515f344be69
https://doi.org/10.1016/j.neuroscience.2016.08.001
https://doi.org/10.1016/j.neuroscience.2016.08.001
Publikováno v:
Forensic Science Policy & Management: An International Journal. 6:69-78
The Thai Tsunami Victim Identification operation was the largest disaster victim identification operation in history, involving 3,679 unidentified victims from 41 countries, and police and forensic scientists from over 30 countries. This paper evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5df8db13fffe0fb6cd48fb97fdd4fa5
https://doi.org/10.1080/19409044.2015.1068887
https://doi.org/10.1080/19409044.2015.1068887
Publikováno v:
Molecular and cellular neurosciences. 88
Zellweger syndrome (ZS), a neonatal lethal disorder arising from defective peroxisome biogenesis, features profound neuroanatomical abnormalities and brain dysfunction. Here we used mice with brain-restricted inactivation of the peroxisome biogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fe7572ced319f5cf36194b80c29120
https://pubmed.ncbi.nlm.nih.gov/29187321
https://pubmed.ncbi.nlm.nih.gov/29187321
Publikováno v:
Neuroscience. 274:229-241
Zellweger syndrome (ZS) is a severe peroxisomal disorder caused by mutations in peroxisome biogenesis, or PEX, genes. A central hallmark of ZS is abnormal neuronal migration and neurodegeneration, which manifests as widespread neurological dysfunctio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d25d1c97b2cb93f9f8510c53a0f1131
https://doi.org/10.1016/j.neuroscience.2014.05.034
https://doi.org/10.1016/j.neuroscience.2014.05.034