Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Denis Guilloteau"'
Autor:
Christine Vala, Céline Mothes, Gabrielle Chicheri, Pauline Magadur, Gilles Viot, Jean-Bernard Deloye, Serge Maia, Yann Bouvet, Anne-Claire Dupont, Nicolas Arlicot, Denis Guilloteau, Patrick Emond, Johnny Vercouillie
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 5, Iss 1, Pp 1-14 (2020)
Abstract Background Fluorine labelled 8-((E)-4-fluoro-but-2-enyl)-3β-p-tolyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ([18F]LBT999) is a selective radioligand for the in vivo neuroimaging and quantification of the dopamine transpo
Externí odkaz:
https://doaj.org/article/cc76bd2c9b0b41288b696111b1292997
Autor:
Jonathan Elie, Johnny Vercouillie, Nicolas Arlicot, Lucas Lemaire, Rudy Bidault, Sylvie Bodard, Christel Hosselet, Jean-Bernard Deloye, Sylvie Chalon, Patrick Emond, Denis Guilloteau, Frédéric Buron, Sylvain Routier
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1-7 (2019)
A series of novel derivatives exhibiting high affinity and selectivity towards the COX-2 enzyme in the (aza) indazole series was developed. A short synthetic route involving a bromination/arylation sequence under microwave irradiation and direct C–
Externí odkaz:
https://doaj.org/article/e9cfd14b1cb34e65971969a050ec7b00
Autor:
Maria-Joao Ribeiro, Johnny Vercouillie, Nicolas Arlicot, Clovis Tauber, Valérie Gissot, Karl Mondon, Laurent Barantin, Jean-Philippe Cottier, Serge Maia, Jean-Bernard Deloye, Patrick Emond, Denis Guilloteau
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Purpose: The density of the neuronal dopamine transporter (DAT) is directly correlated with the presynaptic dopaminergic system injury. In a first study, we evaluated the brain distribution and kinetics of [18F]LBT-999, a DAT PET radioligand, in a gr
Externí odkaz:
https://doaj.org/article/3b7e621efc8e41288c0d9972cc466b78
Autor:
Sylvie Chalon, Johnny Vercouillie, Pierre Payoux, Jean-Bernard Deloye, Cécile Malherbe, Florence Le Jeune, Nicolas Arlicot, Anne-Sophie Salabert, Denis Guilloteau, Patrick Emond, Maria-Joao Ribeiro
Publikováno v:
Frontiers in Medicine, Vol 6 (2019)
The membrane dopamine transporter (DAT) is involved in a number of brain disorders and its exploration by positron emission tomography (PET) imaging is highly relevant for the early and differential diagnosis, follow-up and treatment assessment of th
Externí odkaz:
https://doaj.org/article/fe0d6108515745319cb050faaa6231de
Autor:
Emilie Beaufils, Maria Joao Ribeiro, Emilie Vierron, Johnny Vercouillie, Diane Dufour-Rainfray, Jean-Philippe Cottier, Vincent Camus, Karl Mondon, Denis Guilloteau, Caroline Hommet
Publikováno v:
Dementia and Geriatric Cognitive Disorders Extra, Vol 4, Iss 3, Pp 431-441 (2014)
Background: Posterior cortical atrophy (PCA) is characterized by progressive higher-order visuoperceptual dysfunction and praxis declines. This syndrome is related to a number of underlying diseases, including, in most cases, Alzheimer's disease (AD)
Externí odkaz:
https://doaj.org/article/1a6906e8c8644072aa35b328e4ca987d
Autor:
Clément Thomas MD, Johnny Vercouillie PhD, Aurélie Doméné, Clovis Tauber PhD, Michael Kassiou PhD, Denis Guilloteau PhD, Christophe Destrieux MD, PhD, Sophie Sérrière PhD, Sylvie Chalon PhD
Publikováno v:
Molecular Imaging, Vol 15 (2016)
Subarachnoid hemorrhage (SAH) can lead to delayed cerebral ischemia, which increases the rate of morbidity and mortality. The detection of microglial activation may serve as a biomarker for the identification of patients at risk of this deleterious c
Externí odkaz:
https://doaj.org/article/c96fbf9b602040dab1a0d15413dcb484
Autor:
Fabienne Gourand, Nahid Amini, Zhisheng Jia, Sharon Stone-Elander, Denis Guilloteau, Louisa Barré, Christer Halldin
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137160 (2015)
In quantitative PET measurements, the analysis of radiometabolites in plasma is essential for determining the exact arterial input function. Diphenyl sulfide compounds are promising PET and SPECT radioligands for in vivo quantification of the seroton
Externí odkaz:
https://doaj.org/article/2c6274ff38c74d8cad57cd0784512fbc
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 8, Pp 1209-1219 (2002)
Previous investigations have shown that the lipid composition of cerebral membranes and dopaminergic neurotransmission are changed under chronic α-linolenic acid diet deficiency in the rat. This study investigated whether these changes could be reve
Externí odkaz:
https://doaj.org/article/865fad3c6c3b41a58a805a779e660eef
Autor:
Anne-Claire Dupont, Bérenger Largeau, Maria Joao Santiago Ribeiro, Denis Guilloteau, Claire Tronel, Nicolas Arlicot
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 4, p 785 (2017)
In vivo exploration of activated microglia in neurodegenerative diseases is achievable by Positron Emission Tomography (PET) imaging, using dedicated radiopharmaceuticals targeting the translocator protein-18 kDa (TSPO). In this review, we emphasized
Externí odkaz:
https://doaj.org/article/f8900f6917f6425b81fd6b8375c0b809
Autor:
Nicolas Arlicot, Claire Tronel, Sylvie Bodard, Lucette Garreau, Brice de la Crompe, Inge Vandevelde, Denis Guilloteau, Daniel Antier, Sylvie Chalon
Publikováno v:
Molecular Imaging, Vol 13 (2014)
Excitotoxicity leads to an inflammatory reaction involving an overexpression of: translocator protein 18 kDa (TSPO) in cerebral microglia and astrocytes. Therefore, we performed ex vivo explorations with [ 125 ]-CLINDE, a TSPO-specific radioligand, t
Externí odkaz:
https://doaj.org/article/6f497c42babc46b8bd5b0edaca857d2e