Výsledky vyhledávání

Akademický článek

Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS.

Autor: Babykumari P Chitramuthu, Denis G Kay, Andrew Bateman, Hugh P J Bennett

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0174784 (2017)

Progranulin (PGRN) is a glycoprotein with multiple roles in normal and disease states. Mutations within the GRN gene cause frontotemporal lobar degeneration (FTLD). The affected neurons display distinctive TAR DNA binding protein 43 (TDP-43) inclusio

Externí odkaz: https://doaj.org/article/7c4cec241fe0425a83aed48237314168

Zobrazit plný text záznamu

Akademický článek

Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease.

Autor: Jackalina M Van Kampen, Denis G Kay

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182896 (2017)

Progranulin (PGRN) is a multifunctional protein that is widely expressed throughout the brain, where it has been shown to act as a critical regulator of CNS inflammation and also functions as an autocrine neuronal growth factor, important for long-te

Externí odkaz: https://doaj.org/article/9ec79925fd1f4cdb9d54659a77838755

Zobrazit plný text záznamu

Akademický článek

The Progressive BSSG Rat Model of Parkinson's: Recapitulating Multiple Key Features of the Human Disease.

Autor: Jackalina M Van Kampen, David C Baranowski, Harold A Robertson, Christopher A Shaw, Denis G Kay

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0139694 (2015)

The development of effective neuroprotective therapies for Parkinson's disease (PD) has been severely hindered by the notable lack of an appropriate animal model for preclinical screening. Indeed, most models currently available are either acute in n

Externí odkaz: https://doaj.org/article/821ee5f4b4ef41bf8135975bf5efafb9

Zobrazit plný text záznamu

Akademický článek

Progranulin gene delivery protects dopaminergic neurons in a mouse model of Parkinson's disease.

Autor: Jackalina M Van Kampen, David Baranowski, Denis G Kay

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e97032 (2014)

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by tremor, rigidity and akinesia/bradykinesia resulting from the progressive loss of nigrostriatal dopaminergic neurons. To date, only symptomatic treatment is availab

Externí odkaz: https://doaj.org/article/5eb01808370e4286ae5040e4fe8e3ceb

Zobrazit plný text záznamu

Akademický článek

Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine

Autor: Charlotte Bakker, Jasper van derAart, Ellen P. Hart, Erica S. Klaassen, Kirsten R. Bergmann, Michiel J. vanEsdonk, Denis G. Kay, Geert Jan Groeneveld

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)

Abstract Introduction Gln‐1062 (MEMOGAIN) is an intranasally administered lipophilic prodrug of galantamine. Based on high brain‐to‐blood concentrations observed in pre‐clinical studies, Gln‐1062 is expected to have superior cognitive effic

Externí odkaz: https://doaj.org/article/a354bb9655804faf9b6e8de71a99a031

Zobrazit plný text záznamu

A Quantitative‐EEG Assessment of Alpha‐1062, a Novel Pro‐Drug of Galantamine for the Treatment of Mild to Moderate Dementia Associated with Alzheimer’s Disease

Autor: Denis G Kay, Ellen Stijl‐’t Hart, Charlotte Bakker, Klaus Linkenkaer‐Hansen, Frederick D Sancilio, J. Bryce Ortiz, Geert Jan Groeneveld, Simon‐Shlomo Poil

Publikováno v: Alzheimer's & Dementia. 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc95f1bc8a15639622a13dd6f39fd3f3
https://doi.org/10.1002/alz.068223

Zobrazit plný text záznamu

Animal Models of ALS – Current and Future Perspectives

Autor: Daphne A. Gill, Denis G. Kay, Robert A. Déziel, Amber L. Marriott

Publikováno v: Spectrums of Amyotrophic Lateral Sclerosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58ec211e71c6ac3b803a25935b39527f
https://doi.org/10.1002/9781119745532.ch8

Zobrazit plný text záznamu

Safety, pharmacokinetics, and pharmacodynamics of Gln-1062, a prodrug of galantamine

Autor: Denis G. Kay, Michiel J van Esdonk, Charlotte Bakker, Ellen P. Hart, Kirsten R. Bergmann, Geert Jan Groeneveld, Jasper van der Aart, Erica S. Klaassen

Publikováno v: Alzheimer's and Dementia: Translational Research and Clinical Interventions, 6(1). WILEY
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)

Introduction Gln‐1062 (MEMOGAIN) is an intranasally administered lipophilic prodrug of galantamine. Based on high brain‐to‐blood concentrations observed in pre‐clinical studies, Gln‐1062 is expected to have superior cognitive efficacy compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e4e2bd8a3f4d7dacf9a029154ff26d
https://hdl.handle.net/1887/3278295

Zobrazit plný text záznamu

First in human study with a prodrug of galantamine: Improved benefit-risk ratio?

Autor: Geert Jan Groeneveld, Erica S. Klaassen, Anne Catrien Baakman, Denis G. Kay, Alfred Maelicke, Ellen 't Hart, Jasper Stevens

Publikováno v: Alzheimer's & Dementia : Translational Research & Clinical Interventions

Introduction Gln-1062 (Memogain) is a pharmacologically inactive prodrug of galantamine. Owing to its lipophilic nature, it preferentially enters the brain, where it is cleaved into active galantamine. Gln-1062 is expected to have fewer peripheral si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219c49db25c3f3f295114425a890ef38

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání