Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Denis Firsanov"'
Autor:
Masaki Takasugi, Denis Firsanov, Gregory Tombline, Hanbing Ning, Julia Ablaeva, Andrei Seluanov, Vera Gorbunova
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Naked mole rats are the longest-lived rodents and produce very-high-molecular-mass hyaluronan (vHMM-HA). Here the authors show that naked mole rat vHMM-HA is better at protecting mouse and human cells from cell cycle arrest and cell death, compared t
Externí odkaz:
https://doaj.org/article/3d2c9477f013493bbf1623f28f0b5ae3
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 6, Iss 1, Pp 1-3 (2020)
Abstract Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whethe
Externí odkaz:
https://doaj.org/article/dae01c77a29c49f58149d7b030add56c
Autor:
Denis Firsanov, Max Zacher, Xiao Tian, Yang Zhao, John C. George, Todd L. Sformo, Greg Tombline, Seyed Ali Biashad, Abbey Gilman, Nicholas Hamilton, Avnee Patel, Maggie Straight, Minseon Lee, J. Yuyang Lu, Ena Haseljic, Alyssa Williams, Nalani Miller, Vadim N. Gladyshev, Zhengdong Zhang, Jan Vijg, Andrei Seluanov, Vera Gorbunova
At over 200 years, the maximum lifespan of the bowhead whale exceeds that of all other mammals. The bowhead is also the second-largest animal on Earth, reaching over 80,000 kg1. In spite of its very large number of cells, the bowhead is not highly ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::667ed626ea664fea2a0a7ecfb78f2801
https://doi.org/10.1101/2023.05.07.539748
https://doi.org/10.1101/2023.05.07.539748
Autor:
Zhihui Zhang, Xiao Tian, J. Yuyang Lu, Kathryn Boit, Julia Ablaeva, Frances Tolibzoda Zakusilo, Stephan Emmrich, Denis Firsanov, Elena Rydkina, Seyed Ali Biashad, Quan Lu, Alexander Tyshkovskiy, Vadim N. Gladyshev, Steve Horvath, Andrei Seluanov, Vera Gorbunova
Abundant high molecular weight hyaluronic acid (HMW-HA) contributes to cancer resistance and possibly longevity of the longest-lived rodent, the naked mole-rat1, 2. To study whether the benefits of HMW-HA could be transferred to other animal species,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93c918e800f363106c1e645acc1ea896
https://doi.org/10.1101/2023.05.04.539405
https://doi.org/10.1101/2023.05.04.539405
Autor:
Matthew Simon, Jiping Yang, Jonathan Gigas, Eric J Earley, Eric Hillpot, Lei Zhang, Maria Zagorulya, Greg Tombline, Michael Gilbert, Samantha L Yuen, Alexis Pope, Michael Van Meter, Stephan Emmrich, Denis Firsanov, Advait Athreya, Seyed Ali Biashad, Jeehae Han, Seungjin Ryu, Archana Tare, Yizhou Zhu, Adam Hudgins, Gil Atzmon, Nir Barzilai, Aaron Wolfe, Kelsey Moody, Benjamin A Garcia, Paul D Robbins, Jan Vijg, Andrei Seluanov, Yousin Suh, Vera Gorbunova
Publikováno v:
EMBO J
[Image: see text]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3c355a4b4e1c8dc096517cd316d308
https://europepmc.org/articles/PMC9890223/
https://europepmc.org/articles/PMC9890223/
Autor:
Matthew Simon, Jiping Yang, Jonathan Gigas, Eric J Earley, Eric Hillpot, Lei Zhang, Maria Zagorulya, Greg Tombline, Michael Gilbert, Samantha L Yuen, Alexis Pope, Michael Van Meter, Stephan Emmrich, Denis Firsanov, Advait Athreya, Seyed Ali Biashad, Jeehae Han, Seungjin Ryu, Archana Tare, Yizhou Zhu, Adam Hudgins, Gil Atzmon, Nir Barzilai, Aaron Wolfe, Kelsey Moody, Benjamin A Garcia, David D Thomas, Paul D Robbins, Jan Vijg, Andrei Seluanov, Yousin Suh, Vera Gorbunova
Publikováno v:
The EMBO journal. 41(21)
Sirtuin 6 (SIRT6) is a deacylase and mono-ADP ribosyl transferase (mADPr) enzyme involved in multiple cellular pathways implicated in aging and metabolism regulation. Targeted sequencing of SIRT6 locus in a population of 450 Ashkenazi Jewish (AJ) cen
Autor:
Andrei Seluanov, Gregory Tombline, Michael Gilbert, Vera Gorbunova, David Yang, Natarajan V. Bhanu, Seyed Ali Biashad, Benjamin A. Garcia, Masaki Takasugi, Sarallah Rezazadeh, Denis Firsanov
Publikováno v:
Aging (Albany NY)
When transcribed DNA is damaged, the transcription and DNA repair machineries must interact to ensure successful DNA repair. The mechanisms of this interaction in the context of chromatin are still being elucidated. Here we show that the SIRT6 protei
Autor:
Zhihui Zhang, Xiao Tian, J. Yuyang Lu, Kathryn Boit, Julia Ablaeva, Frances Tolibzoda Zakusilo, Stephan Emmrich, Denis Firsanov, Elena Rydkina, Seyed Ali Biashad, Quan Lu, Alexander Tyshkovsky, Vadim N. Gladyshev, Steve Horvath, Andrei Seluanov, Vera Gorbunova
Publikováno v:
SSRN Electronic Journal.
Autor:
Julia Ablaeva, Jan Vijg, Andrei Seluanov, Vadim N. Gladyshev, Denis Firsanov, Lei Zhang, Vera Gorbunova, Alexander Y. Maslov, Sang-Goo Lee, Xiao Tian, Xiao Dong, Moonsook Lee
Publikováno v:
Science Advances
Description
Somatic mutation rates are inversely correlated with life span in mouse, guinea pig, blind mole-rat, naked mole-rat, and humans.
DNA mutations in somatic cells have been implicated in the causation of aging, with longer-lived sp
Somatic mutation rates are inversely correlated with life span in mouse, guinea pig, blind mole-rat, naked mole-rat, and humans.
DNA mutations in somatic cells have been implicated in the causation of aging, with longer-lived sp
Autor:
Kyle Swovick, Jennifer R. Hryhorenko, Denis Firsanov, Craig George, Sina Ghaemmaghami, Andrei Seluanov, John Pierce Wise, Todd Sformo, Kevin A. Welle, Vera Gorbunova
Cells continually degrade and replace damaged and old proteins. However, the high energetic demand of protein turnover generates reactive oxygen species (ROS) that compromise the long-term health of the proteome. Thus, the relationship between aging,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922c103ccbfa34856479c1377776ed17
https://doi.org/10.1101/2020.04.25.061150
https://doi.org/10.1101/2020.04.25.061150