Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Denis Escande"'
Autor:
Anne-Laure Leoni, Bruno Gavillet, Jean-Sébastien Rougier, Céline Marionneau, Vincent Probst, Solena Le Scouarnec, Jean-Jacques Schott, Sophie Demolombe, Patrick Bruneval, Christopher L H Huang, William H Colledge, Andrew A Grace, Hervé Le Marec, Arthur A Wilde, Peter J Mohler, Denis Escande, Hugues Abriel, Flavien Charpentier
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9298 (2010)
Loss-of-function mutations in SCN5A, the gene encoding Na(v)1.5 Na+ channel, are associated with inherited cardiac conduction defects and Brugada syndrome, which both exhibit variable phenotypic penetrance of conduction defects. We investigated the m
Externí odkaz:
https://doaj.org/article/cdbbe44739414c65b378bc6914b4ef64
Autor:
Stanley Nattel, András Varró, Sabrina Le Bouter, Denis Escande, Nathalie Gaborit, Viktoria Szuts, Sophie Demolombe
Publikováno v:
The Journal of Physiology. 582:675-693
The various cardiac regions have specific action potential properties appropriate to their electrical specialization, resulting from a specific pattern of ion-channel functional expression. The present study addressed regionally defined differential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::921ad76b0d642e7dbd687166175d7f67
https://doi.org/10.1113/jphysiol.2006.126714
https://doi.org/10.1113/jphysiol.2006.126714
Autor:
Pascale Guicheney, Antoine Leenhardt, Jean-Jacques Schott, Iwona Driskell, Dan M. Roden, Solena Le Scouarnec, Richard B. Kim, Isabelle Denjoy, Peter J. Mohler, Denis Escande, Kris Norris, John S. Lowe, Lise Caron
Publikováno v:
Circulation. 115:432-441
Background— Mutations in the ankyrin-B gene ( ANK2 ) cause type 4 long-QT syndrome and have been described in kindreds with other arrhythmias. The frequency of ANK2 variants in large populations and molecular mechanisms underlying the variability i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0666a9fa2a8d77025075fa701bd80781
https://doi.org/10.1161/circulationaha.106.656512
https://doi.org/10.1161/circulationaha.106.656512
Autor:
Stanley Nattel, Nolwenn Le Meur, Denis Escande, Gilles Lande, Sophie Demolombe, Nathalie Gaborit, Marja Steenman, Guillaume Lamirault, Catherine Chevalier, Jean J. Leger
Publikováno v:
Journal of Molecular and Cellular Cardiology. 40:173-184
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. The pathophysiology of AF involves electrical, structural and contractile remodeling, which is associated with changes in cardiac gene expression. Previous studies of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9540d82c527728cf0bdb19d412ed2ee
https://doi.org/10.1016/j.yjmcc.2005.09.004
https://doi.org/10.1016/j.yjmcc.2005.09.004
Autor:
Karinne Haurogne, Marie Madeleine Larroque, Viktoria Szuts, Denis Escande, Renaud Derand, Sophie Demolombe, Jacques Barhanin, Saïd Bendahhou, Céline Marionneau
Publikováno v:
Cardiovascular Research
Cardiovascular Research, Oxford University Press (OUP), 2005, 67, pp.529-538
Cardiovascular Research, Oxford University Press (OUP), 2005, 67, pp.529-538
Objective : The voltage-gated K+ channel KCNQ1 associates with the small KCNE1 β subunit to underlie the IKs repolarizing current in the heart. Based on sequence homology, the KCNE family is recognized to comprise five members. Controversial data ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8301819a90d7a882878b15fc3c31c205
https://doi.org/10.1016/j.cardiores.2005.02.014
https://doi.org/10.1016/j.cardiores.2005.02.014
Autor:
Jean J. Leger, Torsten Christ, Flavien Charpentier, Denis Escande, Sabrina Le Bouter, Nolwenn Le Meur, Dobromir Dobrev, Gilles Lande, Guillaume Lamirault, Marja Steenman, Nathalie Gaborit, Stanley Nattel, Sophie Demolombe
Publikováno v:
Circulation. 112:471-481
Background— Valvular heart disease (VHD), which often leads to atrial fibrillation (AF), and AF both cause ion-channel remodeling. We evaluated the ion-channel gene expression profile of VHD patients, in permanent AF (AF-VHD) or in sinus rhythm (SR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bedb129da0c07dc54e17fc84b944ad
https://doi.org/10.1161/circulationaha.104.506857
https://doi.org/10.1161/circulationaha.104.506857
Autor:
Peggy Richard, Mahajoub Bello-Roufaï, Denis Escande, Hélène Pollard, Bruno Pitard, Noufissa Oudrhiri, Clothilde Gourden, Pierre Lehn, Léa Desigaux
Publikováno v:
Human Gene Therapy. 16:821-829
Various pulmonary disorders, including cystic fibrosis, are potentially amenable to a treatment modality in which a therapeutic gene is directly delivered to the lung. Current gene delivery systems, either viral or nonviral, need further improvement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2203c26bde2d2e07b315a802ce155ca5
https://doi.org/10.1089/hum.2005.16.821
https://doi.org/10.1089/hum.2005.16.821
Autor:
Denis Escande, Guillaume Lamirault, Martine Le Cunff, Jean J. Leger, Marja Steenman, Nolwenn Le Meur
Publikováno v:
European Journal of Heart Failure. 7:157-165
Aims: This study aimed to investigate whether a molecular profiling approach should be pursued for the classification of heart failure patients. Methods and results: Applying a subtraction strategy we created a cDNA library consisting of cardiac- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8857a2482235b1e73063be4867e489
https://doi.org/10.1016/j.ejheart.2004.05.008
https://doi.org/10.1016/j.ejheart.2004.05.008
Autor:
Jean Christophe Chevallier, Flavien Charpentier, Howard Motoike, Cecile Terrenoire, Colleen E. Clancy, Sophie Demolombe, Aziza El Harchi, David Mazurais, Gildas Loussouarn, Chloé Bellocq, Gilles Toumaniantz, Denis Escande, Anne Royer, Gilles Lande, Julien Piron, Khai Le Quang
Publikováno v:
Cardiovascular Research. 65:128-137
Objective: The K + channel encoded by the human ether-a`-go-go-related gene (HERG) is crucial for repolarization in the human heart. In order to investigate the impact of HERG current (IKr) on the incidence of cardiac arrhythmias, we generated a tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e81339ced696e69c697f5f4f5ea66b9f
https://doi.org/10.1016/j.cardiores.2004.09.030
https://doi.org/10.1016/j.cardiores.2004.09.030
Autor:
Brigitte Couette, Huiyu Li, Matteo E. Mangoni, Joël Nargeot, Ming Lei, Sophie Demolombe, Jie Liu, Céline Marionneau, Denis Escande
Publikováno v:
The Journal of Physiology. 562:223-234
Even though sequencing of the mammalian genome has led to the discovery of a large number of ionic channel genes, identification of the molecular determinants of cellular electrical properties in different regions of the heart has been rarely obtaine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f2759e05e34b0fc2cc18232579abc5d
https://doi.org/10.1113/jphysiol.2004.074047
https://doi.org/10.1113/jphysiol.2004.074047