Protein dynamics at invadopodia control invasion–migration transitions in melanoma cells

Autor: Marlène Legrand, Antoine Mousson, Philippe Carl, Léa Rossé, Hélène Justiniano, Jean-Pierre Gies, Daniel Bouvard, Emilie Sick, Denis Dujardin, Philippe Rondé

Publikováno v: Cell Death and Disease, Vol 14, Iss 3, Pp 1-15 (2023)

Abstract Cell invasion is a highly complex process that requires the coordination of cell migration and degradation of the extracellular matrix. In melanoma cells, as in many highly invasive cancer cell types these processes are driven by the regulat

Externí odkaz: https://doaj.org/article/bbce99f838bc44cfb35b5e3cd745d704

Contribution of soft substrates to malignancy and tumor suppression during colon cancer cell division.

Autor: Morgane Rabineau, Leyla Kocgozlu, Denis Dujardin, Bernard Senger, Youssef Haikel, Jean-Claude Voegel, Jean-Noel Freund, Pierre Schaaf, Philippe Lavalle, Dominique Vautier

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e78468 (2013)

In colon cancer, a highly aggressive disease, progression through the malignant sequence is accompanied by increasingly numerous chromosomal rearrangements. To colonize target organs, invasive cells cross several tissues of various elastic moduli. Wh

Externí odkaz: https://doaj.org/article/4080e90125974780a0e4377755a02c6b

The two zinc fingers in the nucleocapsid domain of the HIV-1 Gag precursor are equivalent for the interaction with the genomic RNA in the cytoplasm, but not for the recruitment of the complexes at the plasma membrane

Autor: Serena Bernacchi, Pascal Didier, Halina Anton, Roland Marquet, Philippe Carl, Denis Dujardin, Jeremy Bonzi, Raphael Cathagne, Hugues de Rocquigny, Maaz Bin Nasim, Jean-Christophe Paillart, Yves Mély, Eléonore Réal, Emmanuel Boutant

The HIV-1 Gag precursor specifically selects the unspliced viral genomic RNA (gRNA) from the bulk of cellular and spliced viral RNAsviaits nucleocapsid (NC) domain and drives gRNA encapsidation at the plasma membrane (PM). To further identify the det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08518907a14830dc7136730a3541e6b1
https://doi.org/10.1101/2020.01.24.918508

Zwitterionic Stealth Dye-Loaded Polymer Nanoparticles for Intracellular Imaging

Autor: Andrey S. Klymchenko, Denis Dujardin, Pauline Ernst, Andreas Reisch, Anne Runser

Publikováno v: ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2019, 12 (1), pp.117-125. ⟨10.1021/acsami.9b15396⟩
ACS Applied Materials & Interfaces, 2019, 12 (1), pp.117-125. ⟨10.1021/acsami.9b15396⟩

International audience; Intracellular applications of fluorescent nanoparticles (NPs) as probes and labels are currently limited by the significant molecular crowding and the high level of complexity encountered inside living cells. The solution is t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0eb45483320d7ac31dc0f038b2632d

Role of the Nucleocapsid Domain in HIV-1 Gag Oligomerization and Trafficking to the Plasma Membrane: A Fluorescence Lifetime Imaging Microscopy Investigation

Autor: Salah Edin El Meshri, Hugues de Rocquigny, Jean-Luc Darlix, Ludovic Richert, Yves Mély, Christian Boudier, Pascal Didier, Julien Godet, Denis Dujardin

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2015, 427, pp.1480-1494
Journal of Molecular Biology, Elsevier, 2015, 427 (6 Pt B), pp.1480-1494. ⟨10.1016/j.jmb.2015.01.015⟩
Journal of Molecular Biology, 2015, 427 (6 Pt B), pp.1480-1494. ⟨10.1016/j.jmb.2015.01.015⟩

International audience; The Pr55 Gag of human immunodeficiency virus type 1 orchestrates viral particle assembly in producer cells, which requires the genomic RNA and a lipid membrane as scaffolding platforms. The nucleocapsid (NC) domain with its tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e464b52a91a5705e87ef4f1801001e9
https://doi.org/10.1016/j.jmb.2015.01.015