Zobrazeno 1 - 10
of 295
pro vyhledávání: '"Denis Duboule"'
Autor:
Christopher Chase Bolt, Lucille Lopez-Delisle, Aurélie Hintermann, Bénédicte Mascrez, Antonella Rauseo, Guillaume Andrey, Denis Duboule
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here the authors show that a strong enhancer sequence can be controlled by the chromatin environment provided by a topologically associated domain (TAD) located nearby. An enhancer relocated by homologous recombination takes all the hallmarks of its
Externí odkaz:
https://doaj.org/article/31200988e2c64a1faf824691e328c268
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Mesomelic dysplasia, a severe shortening and bending of the limb, has been linked to rearrangements in the HoxD cluster in humans and mice. Here the authors engineer a 1 Mb inversion including the HoxD gene cluster and use this model to provide a mec
Externí odkaz:
https://doaj.org/article/845162fb54f74e788eb7f21c33002bfc
Autor:
Andréa Willemin, Lucille Lopez-Delisle, Christopher Chase Bolt, Marie-Laure Gadolini, Denis Duboule, Eddie Rodriguez-Carballo
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009691 (2021)
Mammalian genomes are partitioned into sub-megabase to megabase-sized units of preferential interactions called topologically associating domains or TADs, which are likely important for the proper implementation of gene regulatory processes. These do
Externí odkaz:
https://doaj.org/article/258973812dc0457fb34148a8b083a2d4
Autor:
Eddie Rodríguez-Carballo, Lucille Lopez-Delisle, Nayuta Yakushiji-Kaminatsui, Asier Ullate-Agote, Denis Duboule
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-18 (2019)
Abstract Background The spatial organization of the mammalian genome relies upon the formation of chromatin domains of various scales. At the level of gene regulation in cis, collections of enhancer sequences define large regulatory landscapes that u
Externí odkaz:
https://doaj.org/article/b255e7e9ff67451090d74138326008be
Autor:
Ana Rita Amândio, Lucille Lopez-Delisle, Christopher Chase Bolt, Bénédicte Mascrez, Denis Duboule
Publikováno v:
eLife, Vol 9 (2020)
Developmental genes are often controlled by large regulatory landscapes matching topologically associating domains (TADs). In various contexts, the associated chromatin backbone is modified by specific enhancer–enhancer and enhancer–promoter inte
Externí odkaz:
https://doaj.org/article/4ff15e207ff54a9bb67ecfd1524b282e
Autor:
Jozsef Zakany, Denis Duboule
Publikováno v:
BMC Research Notes, Vol 11, Iss 1, Pp 1-5 (2018)
Abstract Objective We had previously reported a mouse line carrying the Atypical female courtship (HoxD Afc ) allele, where an ectopic accumulation of Hoxd10 transcripts was observed in a sparse population of cells in the adult isocortex, as a result
Externí odkaz:
https://doaj.org/article/69382442b5d140d9a0ada344ff3a4c5a
Autor:
Pierre J. Fabre, Marion Leleu, Benjamin H. Mormann, Lucille Lopez-Delisle, Daan Noordermeer, Leonardo Beccari, Denis Duboule
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background The transcriptional activation of HoxD genes during mammalian limb development involves dynamic interactions with two topologically associating domains (TADs) flanking the HoxD cluster. In particular, the activation of the most po
Externí odkaz:
https://doaj.org/article/824243f02c09435d8e35d6514262baa0
Autor:
Nayuta Yakushiji-Kaminatsui, Lucille Lopez-Delisle, Christopher Chase Bolt, Guillaume Andrey, Leonardo Beccari, Denis Duboule
Publikováno v:
PLoS Biology, Vol 16, Iss 11, p e3000004 (2018)
In all tetrapods examined thus far, the development and patterning of limbs require the activation of gene members of the HoxD cluster. In mammals, they are regulated by a complex bimodal process that controls first the proximal patterning and then t
Externí odkaz:
https://doaj.org/article/9b1719bd932d4fb380472a66623e0974
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006232 (2016)
Despite the crucial importance of Hox genes functions during animal development, the mechanisms that control their transcription in time and space are not yet fully understood. In this context, it was proposed that Hotair, a lncRNA transcribed from w
Externí odkaz:
https://doaj.org/article/187e32fff02a4a41850c22feb65c6a39
Autor:
Saskia Delpretti, Thomas Montavon, Marion Leleu, Elisabeth Joye, Athanasia Tzika, Michel Milinkovitch, Denis Duboule
Publikováno v:
Cell Reports, Vol 5, Iss 1, Pp 137-150 (2013)
Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species. We have analyzed the transcriptional regulation of Hoxd genes in cecal buds and show that they are controlled by a series of enhancers located
Externí odkaz:
https://doaj.org/article/259da3d7f6654202bbd1231d588a3117