Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Denis Dermadi"'
Autor:
Samantha Slight-Webb, Kevin Thomas, Miles Smith, Catriona A. Wagner, Susan Macwana, Aleksandra Bylinska, Michele Donato, Mai Dvorak, Sarah E. Chang, Alex Kuo, Peggie Cheung, Laurynas Kalesinskas, Ananthakrishnan Ganesan, Denis Dermadi, Carla J. Guthridge, Wade DeJager, Christian Wright, Mariko H. Foecke, Joan T. Merrill, Eliza Chakravarty, Cristina Arriens, Holden T. Maecker, Purvesh Khatri, Paul J. Utz, Judith A. James, Joel M. Guthridge
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Systemic lupus erythematosus (SLE) affects 1 in 537 Black women, which is >2-fold more than White women. Black patients develop the disease at a younger age, have more severe symptoms, and have a greater chance of early mortality. We used a multiomic
Externí odkaz:
https://doaj.org/article/e17965113ade415ab50fbba3c6fd56ef
Autor:
Ananthakrishnan Ganesan, Denis Dermadi, Laurynas Kalesinskas, Michele Donato, Rosalie Sowers, Paul J. Utz, Purvesh Khatri
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105756- (2023)
Summary: Current technologies do not allow predicting interactions between histone post-translational modifications (HPTMs) at a system-level. We describe a computational framework, imputation-followed-by-inference, to predict directed association be
Externí odkaz:
https://doaj.org/article/9973f3cc1bd84b22a1d0bb6e7b996840
Autor:
Ljubomir Buturovic, Hong Zheng, Benjamin Tang, Kevin Lai, Win Sen Kuan, Mark Gillett, Rahul Santram, Maryam Shojaei, Raquel Almansa, Jose Ángel Nieto, Sonsoles Muñoz, Carmen Herrero, Nikolaos Antonakos, Panayiotis Koufargyris, Marina Kontogiorgi, Georgia Damoraki, Oliver Liesenfeld, James Wacker, Uros Midic, Roland Luethy, David Rawling, Melissa Remmel, Sabrina Coyle, Yiran E. Liu, Aditya M. Rao, Denis Dermadi, Jiaying Toh, Lara Murphy Jones, Michele Donato, Purvesh Khatri, Evangelos J. Giamarellos-Bourboulis, Timothy E. Sweeney
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Predicting the severity of COVID-19 remains an unmet medical need. Our objective was to develop a blood-based host-gene-expression classifier for the severity of viral infections and validate it in independent data, including COVID-19. We de
Externí odkaz:
https://doaj.org/article/ee4e353ebc1a4a9cbf2de80046f1b3f4
Autor:
Kevin Brulois, Anusha Rajaraman, Agata Szade, Sofia Nordling, Ania Bogoslowski, Denis Dermadi, Milladur Rahman, Helena Kiefel, Edward O’Hara, Jasper J. Koning, Hiroto Kawashima, Bin Zhou, Dietmar Vestweber, Kristy Red-Horse, Reina E. Mebius, Ralf H. Adams, Paul Kubes, Junliang Pan, Eugene C. Butcher
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The origin and diversity of blood vascular endothelial cells (BEC) in lymphoid tissues is unclear. Here, the authors profile murine BECs from peripheral lymph nodes by single cell analysis and identify subsets of cells specialised for immune cell rec
Externí odkaz:
https://doaj.org/article/45437c711e144229ae3255403b2c7df7
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101452- (2020)
Summary: DNA mismatch repair (MMR) corrects replication errors and is recruited by the histone mark H3K36me3, enriched in exons of transcriptionally active genes. To dissect in vivo the mutational landscape shaped by these processes, we employed sing
Externí odkaz:
https://doaj.org/article/25aaeba7b1a742b28b9bc3301cad526a
Autor:
Menglan Xiang, Rubén Adrián Grosso, Akira Takeda, Junliang Pan, Tove Bekkhus, Kevin Brulois, Denis Dermadi, Sofia Nordling, Michael Vanlandewijck, Sirpa Jalkanen, Maria H. Ulvmar, Eugene C. Butcher
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Single-cell transcriptomics promise to revolutionize our understanding of the vasculature. Emerging computational methods applied to high-dimensional single-cell data allow integration of results between samples and species and illuminate the diversi
Externí odkaz:
https://doaj.org/article/3be8c70e7a1a4374997f565954bac0c0
Autor:
Denis Dermadi, Michael Bscheider, Kristina Bjegovic, Nicole H. Lazarus, Agata Szade, Husein Hadeiba, Eugene C. Butcher
Publikováno v:
iScience, Vol 23, Iss 2, Pp - (2020)
Summary: High-dimensional single cell profiling coupled with computational modeling is emerging as a powerful tool to elucidate developmental programs directing cell lineages. We introduce tSpace, an algorithm based on the concept of “trajectory sp
Externí odkaz:
https://doaj.org/article/0449d657d72b45c6875a37de6f11f54a
Autor:
Marjaana Pussila, Laura Sarantaus, Denis Dermadi Bebek, Satu Valo, Nima Reyhani, Saara Ollila, Essi Päivärinta, Päivi Peltomäki, Marja Mutanen, Minna Nyström
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76865 (2013)
Colorectal cancer (CRC) is the second most common cause of cancer-related deaths in the Western world and interactions between genetic and environmental factors, including diet, are suggested to play a critical role in its etiology. We conducted a lo
Externí odkaz:
https://doaj.org/article/6a4f2544e21d4c83a88945ff9e157b32
Autor:
Lawrence Bai, Denis Dermadi, Laurynas Kalesinskas, Mai Dvorak, Sarah E Chang, Ananthakrishnan Ganesan, Samuel J S Rubin, Alex Kuo, Peggie Cheung, Michele Donato, Paul J Utz, Aida Habtezion, Purvesh Khatri
Publikováno v:
Journal of Crohn's and Colitis. 17:804-815
Background and Aims Current understanding of histone post-translational modifications [histone modifications] across immune cell types in patients with inflammatory bowel disease [IBD] during remission and flare is limited. The present study aimed to
Autor:
Joni Nikkanen, Yew Ann Leong, William C. Krause, Denis Dermadi, J. Alan Maschek, Tyler Van Ry, James E. Cox, Ethan J. Weiss, Omer Gokcumen, Ajay Chawla, Holly A. Ingraham
Publikováno v:
Science
Science (New York, N.Y.), vol 378, iss 6617
Science (New York, N.Y.), vol 378, iss 6617
Adaptations to infectious and dietary pressures shape mammalian physiology and disease risk. How such adaptations affect sex-biased diseases remains insufficiently studied. In this study, we show that sex-dependent hepatic gene programs confer a robu