Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Denis Delic"'
Autor:
Shyam Nathan, Yifei Wang, Matthew D’ambrosio, Reeba Paul, Huimin Lyu, Denis Delic, Tom Bretschneider, Kimberly Falana, Li Li, Preethi Vijayaraj
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, immune dysregulation, and systemic fibrosis. Research on SSc has been hindered largely by lack of relevant models to study the progressive nature of the disease
Externí odkaz:
https://doaj.org/article/4f95fef11cd74158aa182d9c109c859b
Autor:
Shuya Liu, Yu Zhao, Shun Lu, Tianran Zhang, Maja T. Lindenmeyer, Viji Nair, Sydney E. Gies, Guochao Wu, Robert G. Nelson, Jan Czogalla, Hande Aypek, Stephanie Zielinski, Zhouning Liao, Melanie Schaper, Damian Fermin, Clemens D. Cohen, Denis Delic, Christian F. Krebs, Florian Grahammer, Thorsten Wiech, Matthias Kretzler, Catherine Meyer-Schwesinger, Stefan Bonn, Tobias B. Huber
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-19 (2023)
Abstract Background Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, and histopathologic glomerular lesions are among the earliest structural alterations of DN. However, the signaling pathways that initiate these glomerular
Externí odkaz:
https://doaj.org/article/df3b8422c172486d90e70dad5e72e7ce
Autor:
Om Prakash Dwivedi, Karina Barreiro, Annemari Käräjämäki, Erkka Valo, Anil K. Giri, Rashmi B. Prasad, Rishi Das Roy, Lena M. Thorn, Antti Rannikko, Harry Holthöfer, Kim M. Gooding, Steven Sourbron, Denis Delic, Maria F. Gomez, Per-Henrik Groop, Tiinamaija Tuomi, Carol Forsblom, Leif Groop, Maija Puhka
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106686- (2023)
Summary: Urinary extracellular vesicles (uEV) are a largely unexplored source of kidney-derived mRNAs with potential to serve as a liquid kidney biopsy. We assessed ∼200 uEV mRNA samples from clinical studies by genome-wide sequencing to discover m
Externí odkaz:
https://doaj.org/article/5b53c14dd8ee490b811a4f2dffd31175
Autor:
Yingquan Xiong, Denis Delic, Shufei Zeng, Xin Chen, Chang Chu, Ahmed A. Hasan, Bernhard K. Krämer, Thomas Klein, Lianghong Yin, Berthold Hocher
Publikováno v:
BMC Nephrology, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background Host factors such as angiotensin-converting enzyme 2 (ACE2) and the transmembrane protease, serine-subtype-2 (TMPRSS2) are important factors for SARS-CoV-2 infection. Clinical and pre-clinical studies demonstrated that RAAS-blocki
Externí odkaz:
https://doaj.org/article/d0d3f6c070c84a6a9554fc0945f7e423
Autor:
Karina Barreiro, Abigail C. Lay, German Leparc, Van Du T. Tran, Marcel Rosler, Lusyan Dayalan, Frederic Burdet, Mark Ibberson, Richard J. M. Coward, Tobias B. Huber, Bernhard K. Krämer, Denis Delic, Harry Holthofer
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 2, Pp n/a-n/a (2023)
Abstract Extracellular vesicles (EV) are membranous particles secreted by all cells and found in body fluids. Established EV contents include a variety of RNA species, proteins, lipids and metabolites that are considered to reflect the physiological
Externí odkaz:
https://doaj.org/article/6c45737f12364881b6e1bf461d8da207
Autor:
Yong-Ping Lu, Hong-Wei Wu, Ting Zhu, Xi-Tong Li, Jiao Zuo, Ahmed A. Hasan, Christoph Reichetzeder, Denis Delic, Benito Yard, Thomas Klein, Bernhard K. Krämer, Ze-Yu Zhang, Xiao-Hua Wang, Liang-Hong Yin, Yong Dai, Zhi-Hua Zheng, Berthold Hocher
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113947- (2022)
Background: Sodium glucose cotransporter 2 (SGLT2) inhibitors originally developed for the treatment of type 2 diabetes are clinically very effective drugs halting chronic kidney disease progression. The underlying mechanisms are, however, not fully
Externí odkaz:
https://doaj.org/article/c18782216dc142ad9f32929bbce476b3
Autor:
Xiaoli Zhang, Liping Liu, Mohamed M.S. Gaballa, Ahmed A Hasan, Yingquan Xiong, Li Xie, Thomas Klein, Denis Delic, Burkhard Kleuser, Bernhard K. Krämer, Jian Li, Berthold Hocher
Publikováno v:
Kidney & Blood Pressure Research (2022)
Introduction: The angiotensin-converting enzyme 2 (ACE2) as well as the transmembrane protease serine type 2 (TMPRSS2) have been found to play roles in cell entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing Cor
Externí odkaz:
https://doaj.org/article/a821c7266a894f01bf849f180a29b09d
Autor:
David Lamb, Dorothy De Sousa, Karsten Quast, Katrin Fundel-Clemens, Jonas S. Erjefält, Caroline Sandén, Hans Jürgen Hoffmann, Marc Kästle, Ramona Schmid, Kevin Menden, Denis Delic
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background RORγt is a transcription factor that enables elaboration of Th17-associated cytokines (including IL-17 and IL-22) and is proposed as a pharmacological target for severe asthma. Methods IL-17 immunohistochemistry was performed in
Externí odkaz:
https://doaj.org/article/4625d57e20204c418b1d262620920965
Autor:
Denis Delic, Frank Wunderlich, Saleh Al-Quraishy, Abdel-Azeem S. Abdel-Baki, Mohamed A. Dkhil, Marcos J. Araúzo-Bravo
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-14 (2020)
Abstract Background Vaccination induces survival of otherwise lethal blood-stage infections of the experimental malaria Plasmodium chabaudi. Blood-stage malaria induces extramedullary erythropoiesis in the liver. This study investigates how vaccinati
Externí odkaz:
https://doaj.org/article/e61e4b856b15477aac6dea0f2e147566
Autor:
Shufei Zeng, Denis Delic, Chang Chu, Yingquan Xiong, Ting Luo, Xiaoyi Chen, Mohamed M.S. Gaballa, Yao Xue, Xin Chen, Yaochen Cao, Ahmed A. Hasan, Kai Stadermann, Sandra Frankenreiter, Lianghong Yin, Bernhard K. Krämer, Thomas Klein, Berthold Hocher
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112606- (2022)
To date, the lowest protective SGLT2 inhibitor dose is unknown. We initially performed a dose-response pilot study in normal rats. Based on the results of this pilot study we compared the cardio-renal effects of the SGLT-2 inhibitor empagliflozin, wi
Externí odkaz:
https://doaj.org/article/ecf4c1bf89b94a07a853c6dc47c7eb19