Zobrazeno 1 - 10 of 89 pro vyhledávání: '"Denis Deffieux"'
1
Akademický článek
Preparation of a ε-caprolactonic diterpenoid derivate by unexpected oxidative cleavage/lactonization of 2-oxoaustroeupatol
Autor: Pablo A. Chacón-Morales, Juan M. Amaro-Luis, Luis Beltrán Rojas Fermín, Rémi Jacquet, Denis Deffieux, Laurent Pouységu, Stéphane Quideau
Publikováno v: Natural Products and Bioprospecting, Vol 12, Iss 1, Pp 1-5 (2022)
Abstract From aerial parts of Austroeupatorium inulifolium was isolated the ent-nor-furano triol labdane austroeupatol 1. The compound 1 was treated with IBX showing an unexpected selectivity at the potentially oxidizable sites of the substrate yield
Externí odkaz: https://doaj.org/article/0109b2b3bb2e4a628f53cde6fb5fc008
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2
Akademický článek
Novel 7-Chloro-(4-thioalkylquinoline) Derivatives: Synthesis and Antiproliferative Activity through Inducing Apoptosis and DNA/RNA Damage
Autor: Joyce E. Gutiérrez, Esteban Fernandez-Moreira, Miguel A. Rodríguez, Michael R. Mijares, Juan Bautista De Sanctis, Soňa Gurská, Petr Džubák, Marián Hajdůch, Julia Bruno-Colmenarez, Luis Rojas, Denis Deffieux, Laurent Pouységu, Stéphane Quideau, Jaime Charris, Hegira Ramírez
Publikováno v: Pharmaceuticals, Vol 15, Iss 10, p 1234 (2022)
A series of 78 synthetic 7-chloro-(4-thioalkylquinoline) derivatives were investigated for cytotoxic activity against eight human cancer as well as 4 non-tumor cell lines. The results showed, with some exceptions, that sulfanyl 5–40 and sulfinyl 41
Externí odkaz: https://doaj.org/article/ec01600f92cc479f85cac12e2bcbc218
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4
Synthesis of Flavonol-Bearing Probes for Chemoproteomic and Bioinformatic Analyses of Asteraceae Petals in Search of Novel Flavonoid Enzymes
Autor: Quideau, Karl Kempf, Oxana Kempf, Yoan Capello, Christian Molitor, Claire Lescoat, Rana Melhem, Stéphane Chaignepain, Elisabeth Génot, Alexis Groppi, Macha Nikolski, Heidi Halbwirth, Denis Deffieux, Stéphane
Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9724
This study aimed at searching for the enzymes that are responsible for the higher hydroxylation of flavonols serving as UV-honey guides for pollinating insects on the petals of Asteraceae flowers. To achieve this aim, an affinity-based chemical prote
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::eece14cfb077f4ff83b96fe8786d736d
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5
Bispericyclic Diels–Alder Dimerization of ortho ‐Quinols in Natural Product (Bio)Synthesis: Bioinspired Chemical 6‐Step Synthesis of (+)‐Maytenone
Autor: Mourad El Assal, Cyril Bosset, Anaëlle Cornu, Isabelle Chataigner, Denis Deffieux, Laurent Pouységu, Frédéric Castet, Romain Coffinier, Philippe A. Peixoto, Stéphane Quideau
Publikováno v: Angewandte Chemie International Edition. 60:14967-14974
Many natural products of plant or microbial origins are derived from enzymatic dearomative oxygenation of 2-alkylphenolic precursors into 6-alkyl-6-hydroxycyclohexa-2,4-dienones. These so-called ortho-quinols cyclodimerize via a remarkably selective
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e5e940aac8df36cc30c56dd110688d
https://doi.org/10.1002/anie.202103410
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8
Bio‐inspired Total Synthesis of Twelve Securinega Alkaloids: Structural Reassignments of (+)‐Virosine B and (−)‐Episecurinol A
Autor: Fernando P. Cossío, Stéphane Massip, Stéphane Quideau, Aitor Lacambra, Laurent Pouységu, Kevin Antien, Denis Deffieux, Philippe A. Peixoto
Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2019, 25 (49), pp.11574-11580. ⟨10.1002/chem.201903122⟩
The so-called Securinega alkaloids constitute a class of tetracyclic biologically active specialised metabolites isolated principally from subtropical plants belonging to the Phyllanthaceae family. Following a strategy based on alternative hypotheses
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6847e3b78eacb4cc239397dd1bf6a78f
https://doi.org/10.1002/chem.201903122
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9
Hemisynthesis and Bactericidal Activity of Several Substituted Benzoic Acid Esters of 13(S)-Labdan-8α,15-Diol, a Diterpene from Oxylobus glanduliferus
Autor: Miguel A. Rodriguez Pena, Denis Deffieux, Philippe A. Peixoto, Juan M. Amaro-Luis, Stéphane Quideau, Luis Rojas Fermín, Laurent Pouységu, Nurby Rios Tesch, María Eugenia Lucena Escalona, Rémi Jacquet, Pablo A. Chacón-Morales
Publikováno v: Chemistry of Natural Compounds. 55:677-684
The diterpene 13(S)-labdan-8α,15-diol (1) was isolated in high yield from Oxylobus glanduliferus, a native species of Venezuelan Andean moorlands. Using this compound (1) as a starting material, it was possible to prepare 12 aromatic esters, which w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65f8f9bf72b7bb162319b449f41e04ec
https://doi.org/10.1007/s10600-019-02777-6
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10
Real-Time Analysis of Polyphenol-Protein Interactions by Surface Plasmon Resonance Using Surface-Bound Polyphenols
Autor: Dong Tien Tran, Laëtitia Minder, Laurent Pouységu, Denis Deffieux, Elisabeth Génot, Yoan Capello, Carmelo Di Primo, Philippe A. Peixoto, Sofiane Dairi, Stéphane Quideau, Guillaume Viault, Daniela Melanie Delannoy López
Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, In press, ⟨10.1002/chem.202005187⟩
Chemistry-A European Journal, Wiley-VCH Verlag, In press, ⟨10.1002/chem.202005187⟩
International audience; A selection of bioactive polyphenols of different structural classes, such as the ellagitannins vescalagin and vescalin, the flavanoids catechin, epicatechin, epigallocatechin gallate (EGCG), and procyanidin B2, and the stilbe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf20b83a5d7603b8a70defcf679ce2e1
https://hal.science/hal-03374449
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