Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Denis Danvy"'
Autor:
Thierry Calmels, Olivier Labeeuw, Xavier Billot, Xavier Ligneau, Jeanne-Marie Lecomte, Isabelle Berrebi-Bertrand, Stéphane Krief, Denis Danvy, Nicolas Levoin, Marc Capet, Jean-Charles Schwartz, Philippe Robert
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5263-5266
Synthesis and biological evaluation of a new class of histamine H4 receptor ligands, distinct from the previously reported chemotypes, are described. A virtual screening of our corporate compound collection identified a hit with an undesired dual H3R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7b7ff1da6a5c21956feeeb57c288e6
https://doi.org/10.1016/j.bmcl.2016.09.049
https://doi.org/10.1016/j.bmcl.2016.09.049
Autor:
Thierry Calmels, Jean-Charles Schwartz, Nicolas Levoin, Denis Danvy, Xavier Billot, Isabelle Berrebi-Bertrand, Marc Capet, Stéphane Krief, Jeanne-Marie Lecomte, Olivier Labeeuw
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2017, 125, pp.565-572. ⟨10.1016/j.ejmech.2016.09.074⟩
European Journal of Medicinal Chemistry, Elsevier, 2017, 125, pp.565-572. ⟨10.1016/j.ejmech.2016.09.074⟩
European Journal of Medicinal Chemistry, 2017, 125, pp.565-572. ⟨10.1016/j.ejmech.2016.09.074⟩
European Journal of Medicinal Chemistry, Elsevier, 2017, 125, pp.565-572. ⟨10.1016/j.ejmech.2016.09.074⟩
International audience; The involvement of histamine H4 receptor (H4R) in immune cells chemotaxis and mediator release makes it an attractive target for the treatment of inflammation disorders. A decade of medicinal chemistry efforts has led to sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e8c3ee3a7850571d827909378c18b6
https://normandie-univ.hal.science/hal-02046295
https://normandie-univ.hal.science/hal-02046295
Autor:
Denis Danvy, Mickael Jean, Philippe Robert, J.-C. Schwartz, Thierry Calmels, Marc Capet, Nicolas Levoin, Jacques Renault, Philippe Uriac, Isabelle Berrebi-Bertrand, J.M. Lecomte
Publikováno v:
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2010, 20 (18), pp.5376-9. ⟨10.1016/j.bmcl.2010.07.096⟩
Bioorganic and Medicinal Chemistry Letters, 2010, 20 (18), pp.5376-9. ⟨10.1016/j.bmcl.2010.07.096⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2010, 20 (18), pp.5376-9. ⟨10.1016/j.bmcl.2010.07.096⟩
Bioorganic and Medicinal Chemistry Letters, 2010, 20 (18), pp.5376-9. ⟨10.1016/j.bmcl.2010.07.096⟩
International audience; Isosteric replacement of the amide function and modulation of the arylpiperazine moiety of known dopamine D3 receptor ligands led to potent and selective compounds. Enhanced bioavailability and preferential brain distribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9222bfc5cd67f9255285875f12e25a
https://doi.org/10.1016/j.bmcl.2010.07.096
https://doi.org/10.1016/j.bmcl.2010.07.096
Autor:
Thierry Calmels, Marc Capet, Philippe Robert, Olivier Labeeuw, Denis Danvy, Olivia Poupardin-Olivier, Isabelle Berrebi-Bertrand, C. Robin Ganellin, Walter Schunack, Nicolas Levoin, Holger Stark
Publikováno v:
Archiv der Pharmazie. 341:610-623
Drug-discovery projects frequently employ structure-based information through protein modeling and ligand docking, and there is a plethora of reports relating successful use of them in virtual screening. Hit/lead optimization, which represents the ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8b19814e73bd941d62e1f40b9d3609
https://doi.org/10.1002/ardp.200800042
https://doi.org/10.1002/ardp.200800042
Autor:
Jean-Christophe Plaquevent, Jeanne-Marie Lecomte, Pierre Duhamel, Denis Danvy, Lucette Duhamel, Jean-Charles Schwartz, Thierry Monteil, Claude Gros
Publikováno v:
Synthetic Communications. 31:211-218
We describe herein a method providing access to both enantiomers of 3-acetylthio-2-benzylpropionic acid via enzymatic desymmetrization of 2-benzyl-1,3-propanediol. These compounds are respectively the starting materials for the synthesis of ecadotril
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::262c61b737d7c25469e52dc8c609b839
https://doi.org/10.1081/scc-100000201
https://doi.org/10.1081/scc-100000201
Autor:
Jean-Charles Schwartz, Lucette Duhamel, Jeanne-Marie Lecomte, Denis Danvy, Claude Gros, Jean-Christophe Plaquevent, Thierry Monteil, Nadine Noel, Pierre Duhamel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2437-2440
The preferred conformation of thiorphan during the inhibitor-neprilysin docking process was investigated. A series of achiral inhibitors were tested. This study led to the design of a potent inhibitor, in which the ethylenic bond bears the aryl resid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eedce172988cf0b4854c502db0a4ab7
https://doi.org/10.1016/0960-894x(96)00448-9
https://doi.org/10.1016/0960-894x(96)00448-9
Autor:
Jean-Charles Schwartz, Isabelle Berrebi-Bertrand, Denis Danvy, Thierry Calmels, Marc Capet, Stéphane Krief, Jeanne-Marie Lecomte, Nicolas Levoin
Structure-based design methods commonly used in medicinal chemistry rely on a three-dimensional representation of the receptor. However, few crystal structures are solved in comparison with the huge number of pharmaceutical targets. This often render
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83aaa831dc292715495a664c0dfe4870
https://europepmc.org/articles/PMC4018084/
https://europepmc.org/articles/PMC4018084/
Autor:
Pierre Duhamel, Claude Gros, Jean-Charles Schwartz, Denis Danvy, Lucette Duhamel, Jeanne-Marie Lecomte, Jean-Christophe Plaquevent, Thierry Monteil
Publikováno v:
ChemInform. 32
We describe herein a method providing access to both enantiomers of 3-acetylthio-2-benzylpropionic acid via enzymatic desymmetrization of 2-benzyl-1,3-propanediol. These compounds are respectively the starting materials for the synthesis of ecadotril
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a784365153de62b7f3da713b579cb47
https://doi.org/10.1002/chin.200127092
https://doi.org/10.1002/chin.200127092
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5264300913cbd7528377a989f08081ab
https://doi.org/10.1002/chin.200248259
https://doi.org/10.1002/chin.200248259
Autor:
Mickael Jean, Denis Danvy, Holger Stark, Marc Capet, Philippe Uriac, Jacques Renault, Jean-Claude Camelin, Nicolas Levoin
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 23(5)
A solid phase parallel synthesis using SynPhase technology was used to couple a series of 21 carboxylic with three different 4-(4-arylpiperazinyl)butanamines. The resulting library was evaluated as dopamine D(3) receptor ligands giving rise to severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0de55e0642640cfa258ca3ecfd1703
https://pubmed.ncbi.nlm.nih.gov/18608769
https://pubmed.ncbi.nlm.nih.gov/18608769