Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Denis Brochu"'
Autor:
Janelle Sauvageau, Izel Koyuturk, Frank St. Michael, Denis Brochu, Marie-France Goneau, Ian Schoenhofen, Sylvie Perret, Alexandra Star, Anna Robotham, Arsalan Haqqani, John Kelly, Michel Gilbert, Yves Durocher
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Glycosylation is a key quality attribute that must be closely monitored for protein therapeutics. Established assays such as HILIC-Fld of released glycans and LC-MS of glycopeptides work well for glycoproteins with a few glycosylation sites
Externí odkaz:
https://doaj.org/article/b6b1904909a242f99f4b91f266f9ce1c
Autor:
Florian Cambay, Céline Raymond, Denis Brochu, Michel Gilbert, The Minh Tu, Christiane Cantin, Anne Lenferink, Maxime Grail, Olivier Henry, Gregory De Crescenzo, Yves Durocher
Publikováno v:
Current Research in Immunology, Vol 1, Iss , Pp 23-37 (2020)
The effector functions of the IgGs are modulated by the N-glycosylation of their Fc region. Particularly, the absence of core fucosylation is known to increase the affinity of IgG1s for the Fcγ receptor IIIa expressed by immune cells, in turn transl
Externí odkaz:
https://doaj.org/article/08e98cb3fa604f8f883c571e07d19a71
Autor:
Warren W Wakarchuk, Denis Brochu, Simon Foote, Anna Robotham, Hirak Saxena, Tamara Erak, John Kelly
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151186 (2016)
The bacteria in the genus Cellulomonas are known for their ability to degrade plant cell wall biomass. Cellulomonas fimi ATCC 484 and C. flavigena ATCC 482 have been the subject of much research into secreted cellulases and hemicellulases. Recently t
Externí odkaz:
https://doaj.org/article/2fb1e21922f94dd6bd9f96060cb4d340
Autor:
Hirak Saxena, Nakita Buenbrazo, Won-Yong Song, Connie Li, Denis Brochu, Anna Robotham, Wen Ding, Luc Tessier, Rui Chen, John Kelly, Warren Wakarchuk
Publikováno v:
Glycobiology.
The Actinobacterial species Cellulomonas fimi ATCC484 has long been known to secrete mannose-containing proteins, but a closer examination of glycoproteins associated with the cell has never been reported. Using ConA lectin chromatography and mass sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87ded9a8064ec8e59cd8c54e3a3c70f0
https://doi.org/10.1093/glycob/cwad023
https://doi.org/10.1093/glycob/cwad023
Autor:
Izel Koyuturk, Surbhi Kedia, Anna Robotham, Alexandra Star, Denis Brochu, Janelle Sauvageau, John Kelly, Michel Gilbert, Yves Durocher
Publikováno v:
Biotechnology and Bioengineering. 119
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5acf44b3553b84e1e7fea509da157996
https://doi.org/10.1002/bit.28204
https://doi.org/10.1002/bit.28204
Autor:
Denis Brochu, Maxime Grail, Olivier Henry, Christiane Cantin, Yves Durocher, Céline Raymond, Anne E.G. Lenferink, Florian Cambay, Gregory De Crescenzo, Michel Gilbert
Publikováno v:
Current Research in Immunology, Vol 1, Iss, Pp 23-37 (2020)
The effector functions of the IgGs are modulated by the N-glycosylation of their Fc region. Particularly, the absence of core fucosylation is known to increase the affinity of IgG1s for the Fcγ receptor IIIa expressed by immune cells, in turn transl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb83e7971f5bdbb8d6c9d3ef43f7567c
http://www.sciencedirect.com/science/article/pii/S2590255520300032
http://www.sciencedirect.com/science/article/pii/S2590255520300032
Autor:
Izel Koyuturk, Surbhi Kedia, Anna Robotham, Alexandra Star, Denis Brochu, Janelle Sauvageau, John Kelly, Michel Gilbert, Yves Durocher
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 119(9)
Alpha-1-antitrypsin (A1AT) is a serine protease inhibitor which blocks the activity of serum proteases including neutrophil elastase to protect the lungs. Its deficiency is known to increase the risk of pulmonary emphysema as well as chronic obstruct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af05b8969636b0bbb1e9fdd4a8622e07
https://pubmed.ncbi.nlm.nih.gov/35508753
https://pubmed.ncbi.nlm.nih.gov/35508753
Autor:
Michel Gilbert, Yves Durocher, Jonathan Jabbour, Marie-Eve Lalonde, Denis Brochu, Izel Koyuturk
Publikováno v:
Journal of Biotechnology. 307:87-97
Alpha-1-antitrypsin (A1AT) is an abundant serum inhibitor of serine proteases. A1AT deficiency is a common genetic disorder which is currently treated with augmentation therapies. These treatments involve weekly injections of patients with purified p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87c05f9c2fe08d0a3a85118e145e0b4
https://doi.org/10.1016/j.jbiotec.2019.10.021
https://doi.org/10.1016/j.jbiotec.2019.10.021
Autor:
Michel Gilbert, Denis Brochu, Olivier Henry, Michel Perrier, Kahina Mellahi, Sven Ansorge, Yves Durocher
Publikováno v:
Bioprocess and Biosystems Engineering. 42:711-725
Mammalian-inducible expression systems are increasingly available and offer an attractive platform for the production of recombinant proteins. In this work, we have conducted process development for a cumate-inducible GS-CHO cell-line-expressing ritu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9a6dd49d7de21f2caf98b409484953
https://doi.org/10.1007/s00449-019-02075-z
https://doi.org/10.1007/s00449-019-02075-z
Autor:
Warren W. Wakarchuk, Denis Brochu, Simon J. Foote, John F. Kelly, Tamara Erak, Hirak Saxena, Anna Robotham
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151186 (2016)
PLoS ONE
PLoS ONE
The bacteria in the genus Cellulomonas are known for their ability to degrade plant cell wall biomass. Cellulomonas fimi ATCC 484 and C. flavigena ATCC 482 have been the subject of much research into secreted cellulases and hemicellulases. Recently t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71577a86350f88e3e60a74cb725aa1c2
https://doi.org/10.32920/14638806
https://doi.org/10.32920/14638806
