Výsledky vyhledávání - "Denis Blache"

Akademický článek

Polysaccharide Chain Length of Lipopolysaccharides From Salmonella Minnesota Is a Determinant of Aggregate Stability, Plasma Residence Time and Proinflammatory Propensity in vivo

Autor: Wahib Sali, Danish Patoli, Jean-Paul Pais de Barros, Jérôme Labbé, Valérie Deckert, Vincent Duhéron, Naig Le Guern, Denis Blache, Denis Chaumont, Eric Lesniewska, Benoit Gasquet, Catherine Paul, Mathieu Moreau, Franck Denat, David Masson, Laurent Lagrost, Thomas Gautier

Publikováno v: Frontiers in Microbiology, Vol 10 (2019)

Lipopolysaccharides (LPS) originate from the outer membrane of Gram-negative bacteria and trigger an inflammatory response via the innate immune system. LPS consist of a lipid A moiety directly responsible for the stimulation of the proinflammatory c

Externí odkaz: https://doaj.org/article/8bced7c847df48ccae8e7cc0b244d0d3

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Glycation of Apolipoprotein C1 Impairs Its CETP Inhibitory Property: Pathophysiological Relevance in Patients With Type 1 and Type 2 Diabetes

Autor: Bruno Vergès, Denis Blache, Jean-Michel Petit, Laurent Lagrost, Benjamin Bouillet, Jean-Paul Pais de Barros, Thomas Gautier, Laurence Duvillard

Publikováno v: Diabetes Care. 37:1148-1156

OBJECTIVE Apolipoprotein (apo)C1 is a potent physiological inhibitor of cholesteryl ester transfer protein (CETP). ApoC1 operates through its ability to modify the electrostatic charge at the lipoprotein surface. We aimed to determine whether the inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fac79245dab434da30b234243ae27a7
https://doi.org/10.2337/dc13-1467

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Liver X Receptor Regulates Arachidonic Acid Distribution and Eicosanoid Release in Human Macrophages

Autor: Denis Blache, Philippe Gambert, Thomas Gautier, Minako Ishibashi, Anne Athias, Charles Thomas, Laurent Lagrost, Tatiana Lopez, Rodolphe Filomenko, David Masson, Alexis Varin

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 33:1171-1179

Objective— Liver X receptors (LXRs) are oxysterol-activated nuclear receptors that are highly expressed in macrophages and regulate lipid homeostasis and inflammation. Among putative LXR target genes, lysophosphatidylcholine acyltransferase 3 (LPCA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0a3c4a24b25d8e89e25482e1535de4
https://doi.org/10.1161/atvbaha.112.300812

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Activated platelets contribute to oxidized low‐density lipoproteins and dysfunctional high‐density lipoproteins through a phospholipase A2‐dependent mechanism

Autor: Thomas Gautier, Denis Blache, Laurent Lagrost, Uwe J. F. Tietge

Publikováno v: The FASEB Journal, 26(2), 927-937. FEDERATION AMER SOC EXP BIOL

Plasma activity of secretory phospholipase A2 (sPLA2) increases in patients with cardiovascular disease. The present study investigated whether platelet-released sPLA2 induces low-density lipoprotein (LDL) and high-density lipoprotein (HDL) modificat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56956a88d8f347bd0de4e8b053f6d8d2
https://doi.org/10.1096/fj.11-191593

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Plasma Phospholipid Transfer Protein Deficiency in Mice Is Associated With a Reduced Thrombotic Response to Acute Intravascular Oxidative Stress

Autor: Laurent Lagrost, Emmanuel De Maistre, David Vandroux, Christine Marie, Serge Monier, Jean-Paul Pais de Barros, Catherine Desrumaux, Stéphanie Lemaire-Ewing, Denis Blache, Valérie Deckert, Laure Dumont, Philippe Garnier, Claude Mossiat, Anne Athias, Alexis Klein, Alain Beley

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2010, 30 (12), pp.2452-2457. ⟨10.1161/ATVBAHA.110.207654⟩

Objective— Earlier in vitro studies suggested a putative role for the plasma phospholipid transfer protein (PLTP) in the modulation of blood coagulation. The effect of PLTP expression on blood coagulation under both basal and oxidative stress condi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49f7ac26df95c4a97b014ed238b8d5b
https://doi.org/10.1161/atvbaha.110.207654

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Differential effects of oxidized LDL on apolipoprotein AI and B synthesis in HepG2 cells

Autor: Denis Blache, Jean Davignon, Nadine Loreau, Lise Bernier, Emmanuel Bourdon, Laurent Lagrost

Publikováno v: Free Radical Biology and Medicine. 41:786-796

Oxidized low-density lipoproteins (Ox-LDL) are key elements in atherogenesis. Apolipoprotein AI (apoAI) is an active component of the antiatherogenic high-density lipoproteins (HDL). In contrast, plasma apolipoprotein B (apoB), the main component of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6073799e5bee81c6470d76063284b0
https://doi.org/10.1016/j.freeradbiomed.2006.05.028

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Long-term moderate magnesium-deficient diet shows relationships between blood pressure, inflammation and oxidant stress defense in aging rats

Autor: Markus Adrian, Olivier Joubert, Denis Blache, Philippe Durand, Martina Schneider, Sylvie Devaux, Alain Berthelot, Vincent Gaume, Michel Prost, Pascal Laurant, Nadine Loreau

Publikováno v: Free Radical Biology and Medicine
Free Radical Biology and Medicine, Elsevier, 2006, 41 (2), pp.277-284. ⟨10.1016/j.freeradbiomed.2006.04.008⟩

International audience; Epidemiological and experimental studies have indicated a relationship among aging, dietary Mg, inflammatory stress, and cardiovascular disease. Our aim in the present study was to investigate possible links between dietary Mg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f4ce3d1247bff43815be5683717a0a
https://doi.org/10.1016/j.freeradbiomed.2006.04.008

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Differential effects of cysteine and methionine residues in the antioxidant activity of human serum albumin

Autor: Nadine Loreau, Laurent Lagrost, Denis Blache, Emmanuel Bourdon

Publikováno v: Free Radical Research. 39:15-20

Antioxidant properties of human serum albumin (HSA) may explain part of its beneficial role in various diseases related to free radical attack. In the present study, the antioxidant role of Cys and Met was studied by copper-mediated oxidation of huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5b2f2feffc91058bc4be93f5b85bee
https://doi.org/10.1080/10715760400024935

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(+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo

Autor: Michel Prost, Nadine Loreau, Philippe Durand, Denis Blache

Publikováno v: Free Radical Biology and Medicine. 33:1670-1680

Reactive oxygen species and platelets are thought to be involved in the pathogenesis of cardiovascular disease. Epidemiological data have indicated that high consumption of fruits and vegetables is associated with a lower incidence of vascular events

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbfb2e423c74aa9d458e3d37ac1fc43
https://doi.org/10.1016/s0891-5849(02)01139-5

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Glycated albumin with loss of fatty acid binding capacity contributes to enhanced arachidonate oxygenation and platelet hyperactivity: relevance in patients with type 2 diabetes

Autor: Pauline Salloignon, Denis Blache, Bruno Vergès, Jean-Michel Petit, Patrick Ducoroy, Emmanuel Bourdon, Laurent Lagrost, Géraldine Lucchi

Publikováno v: Diabetes. 64(3)

High plasma concentrations of nonesterified fatty acids (NEFAs), transported bound to serum albumin, are associated with type 2 diabetes (T2D). The effects of albumin on platelet function were investigated in vitro. Modifications of albumin, such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057bdbc00c247d69e84ee9081d88c1f4
https://pubmed.ncbi.nlm.nih.gov/25713195

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