Combinations of susceptibility genes are associated with higher risk for multiple sclerosis and imply disease course specificity.

Autor: Denis A Akkad, Alexandra Olischewsky, Franziska Reiner, Kerstin Hellwig, Sarika Esser, Jörg T Epplen, Tomaz Curk, Ralf Gold, Aiden Haghikia

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0127632 (2015)

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that predominantly affects young adults. The genetic contributions to this multifactorial disease were underscored by a genome wide association study (GWAS) conduct

Externí odkaz: https://doaj.org/article/4eefe1aa1ec54821a0ff63f5b03cb496

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

Autor: Stefanie Jörg, Denis A. Akkad, Anne Waschbisch, Nils Helge Schebb, Caroline May, Alexander Duscha, Stefan Kempa, Aiden Haghikia, Ralf Gold, Diana A. Grohme, Markus Kleinewietfeld, Jan Thöne, Johannes Berg, Annika I. Ostermann, András Balogh, Nicola Wilck, Dominik N. Müller, Anna Hammer, Seray Demir, Ralf A. Linker, Arndt Manzel, De-Hyung Lee

Publikováno v: Immunity. 43(4):817-829

SummaryGrowing empirical evidence suggests that nutrition and bacterial metabolites might impact the systemic immune response in the context of disease and autoimmunity. We report that long-chain fatty acids (LCFAs) enhanced differentiation and proli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea8c7f3ccc7e1c3a92bac89af9eb58b

Interferon-beta affects mitochondrial activity in CD4+ lymphocytes: Implications for mechanism of action in multiple sclerosis

Autor: Bartosz Pula, Derek J. Pappas, Xavier Montalban, Larissa Arning, Ralf Gold, Simon Faissner, Andrew T. Chan, Sergio E. Baranzini, Manuel Comabella, Denis A. Akkad, Aiden Haghikia, Sunny Malhotra, Alexander Duscha, Sabrina Ruhrmann

Publikováno v: Multiple Sclerosis Journal. 21:1262-1270

Background: Whereas cellular immune function depends on energy supply and mitochondrial function, little is known on the impact of immunotherapies on cellular energy metabolism. Objective: The objective of this paper is to assess the effects of inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29787fb8dd296c0de2d4f3bfb723bcbb
https://doi.org/10.1177/1352458514561909

Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients

Autor: Thomas Berger, Franz Fazekas, A. Dessa Sadovnick, Lars Bertram, José C. Álvarez-Cermeño, Orhan Aktas, Mathias Buttmann, Cecily Q. Bernales, Irene M. Yee, Antonio Alcina, Kelly Hilven, Bénédicte Dubois, M. Schmied, Joerg T. Epplen, Uwe K. Zettl, Carles Vilariño-Güell, Jay P. Ross, Anthony Traboulsee, Patricia Urbaneja, Alexander Zimprich, Iraide Alloza, Lisa Ann Gerdes, Ianire Astobiza, Peter Lohse, Angel Garcia-Martinez, Fuencisla Matesanz, Guillermo Izquierdo, Aroa M. Garagorri, Tania Kümpfel, Koen Vandenbroeck, Alfredo Antigüedad, Bertrand Fontaine, Manuel Comabella, Oscar Fernandez, Denis A. Akkad, Paul Blaschke, Peter Rieckmann, Xavier Montalban, Christian Kubisch, Markus Reindl, Isabelle Cournu-Rebeix, Elena Urcelay, Lena Guillot-Noel, Frauke Zipp, Andrew T. Chan, Sunny Malhotra, Rafael Arroyo, An Goris, Antje Kroner, Luisa M. Villar, María Fedetz, Amanda L. Forwell, Christina M. Lill, Laura Leyva

Publikováno v: Sadovnick, A Dessa; Traboulsee, Anthony L; Bernales, Cecily Q; Ross, Jay P; Forwell, Amanda L; Yee, Irene M; Guillot-Noel, Lena; Fontaine, Bertrand; Cournu-Rebeix, Isabelle; Alcina, Antonio; Fedetz, Maria; Izquierdo, Guillermo; Matesanz, Fuencisla; Hilven, Kelly; Dubois, Bénédicte; Goris, An; Astobiza, Ianire; Alloza, Iraide; Antigüedad, Alfredo; Vandenbroeck, Koen; ... (2016). Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients. G3 Genes Genomes Genetics, 6(7), pp. 2073-2079. Genetics Society of America 10.1534/g3.116.030841
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G3: Genes, Genomes, Genetics, Vol 6, Iss 7, Pp 2073-2079 (2016)
G3: Genes|Genomes|Genetics

Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we describe the characterization of a multi-incident MS family that nominated a rare missense variant (p.G420D) in plasminogen (PLG) as a putative genetic risk fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f159b6d80fdf536b62121bc5446912ef

Generalized progressive retinal atrophy in the Irish Glen of Imaal Terrier is associated with a deletion in the ADAM9 gene

Autor: Annegrit Schlichting, Denis A. Akkad, Joerg T. Epplen, Regina Kropatsch, Gabriele Dekomien, Elisabeth Petrasch-Parwez, Dominik Seelow, Wanda M. Gerding

Publikováno v: Molecular and Cellular Probes. 24:357-363

Generalized progressive retinal atrophy (gPRA) belongs to a group of inherited retinal diseases which are associated with gradual vision loss in various dog breeds, including the Irish Glen of Imaal Terrier (GIT). By genome-wide homozygosity mapping

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea150a685b9770bd93845ee2e014f71c
https://doi.org/10.1016/j.mcp.2010.07.007