Zobrazeno 1 - 10
of 307
pro vyhledávání: '"Denis, Wakefield"'
Autor:
Peter J McCluskey, Richard Symes, Sophia Zagora, Denis Wakefield, Nitin Verma, Timothy Lee Tang Lee Say, Verlyn Yang, Jacob M Fingret, Christine Younan, Elisa Eleanor Cornish, Anthony Sammel, Deborah Speden
Publikováno v:
BMJ Open Ophthalmology, Vol 6, Iss 1 (2021)
Objectives Biologics are rapidly emerging as an effective vision saving addition to systemic uveitis therapy. The aim of this multicentre retrospective study is to review the outcomes of a large group of patients treated with adalimumab.Methods A ret
Externí odkaz:
https://doaj.org/article/7c6dbb33da9f4c9288fae3d87d75ca5b
Autor:
Mijeong Park, Alexander Richardson, Elvis Pandzic, Erwin P. Lobo, Renee Whan, Stephanie L. Watson, J. Guy Lyons, Denis Wakefield, Nick Di Girolamo
Publikováno v:
Stem Cell Reports, Vol 12, Iss 1, Pp 14-28 (2019)
Summary: It is thought that corneal epithelial injuries resolve by leading-edge cells “sliding” or “rolling” into the wound bed. Here, we challenge this notion and show by real-time imaging that corneal wounds initially heal by “basal cell
Externí odkaz:
https://doaj.org/article/d5ad1a27982e4dfa9e43c6206adbecad
Autor:
Rohit, Parthasarathy, Fernando, Santiago, Peter, McCluskey, Nadeem O, Kaakoush, Nicodemus, Tedla, Denis, Wakefield
Publikováno v:
Trends in Microbiology. 31:142-158
The pathogenesis of human leukocyte antigen (HLA)-B27-associated diseases such as acute anterior uveitis (AAU) and ankylosing spondylitis (AS) remains poorly understood, though Gram-negative bacteria and subclinical bowel inflammation are strongly im
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
There has been steady progress in understanding the pathogenesis, clinical features, and effective treatment of acute anterior uveitis (AU) over the past 5 years. Large gene wide association studies have confirmed that AU is a polygenic disease, with
Externí odkaz:
https://doaj.org/article/5661bc2396c4418d961baee6a3a9ccaf
Autor:
Denis Wakefield, Gerhild Wildner
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 10, Pp n/a-n/a (2020)
Abstract There is increasing evidence from animal and human studies that glaucoma is an autoimmune disease. Evidence for this hypothesis includes the fact that antibodies as well as T‐cell responses to heat‐shock proteins (HSPs) are detectable in
Externí odkaz:
https://doaj.org/article/a60da00f49984a6b88488b7468dfe06d
Autor:
Alexander Richardson, Erwin P. Lobo, Naomi C. Delic, Mary R. Myerscough, J. Guy Lyons, Denis Wakefield, Nick Di Girolamo
Publikováno v:
Stem Cell Reports, Vol 9, Iss 4, Pp 1081-1096 (2017)
The dynamics of epithelial stem cells (SCs) that contribute to the formation and maintenance of the cornea are poorly understood. Here, we used K14CreERT2-Confetti (Confetti) mice, sophisticated imaging, and computational modeling to trace the origin
Externí odkaz:
https://doaj.org/article/dc668e8b1e6340b2948e87f791b34e16
Publikováno v:
The Ocular Surface. 21:145-159
Purpose Dry eye disease (DED) is characterized by loss of tear film stability that becomes self-sustaining in a vicious cycle of pathophysiological events. Currently, desiccation stress (DS) is the dominant procedure for inducing DED in mice, however
Autor:
Hui Li, Erin Cvejic, Denis Wakefield, Ian B. Hickie, Tracey A Davenport, Andrew R. Lloyd, Ben J. Gu, James S. Wiley, Ute Vollmer-Conna
Publikováno v:
The Journal of Infectious Diseases. 224:914-920
Background The acute sickness response to infection is a stereotyped set of illness manifestations initiated by proinflammatory signals in the periphery but mediated centrally. P2RX7 is a highly polymorphic gene encoding an ATP-gated cationic pore, w
Autor:
Elvis Pandzic, Stephanie L Watson, Cintia S. de Paiva, Richard Zhang, Nick Di Girolamo, Alexander Richardson, Mijeong Park, Nicodemus Tedla, Denis Wakefield
Publikováno v:
The Ocular Surface. 18:158-169
Purpose Inclusion of the preservative benzalkonium chloride (BAC) in ophthalmic solutions is prevalent, despite the noted potential for exacerbating dry eye disease (DED). Whilst studies incorporating BAC have assessed its’ effects as a mouse model
Publikováno v:
Ocular immunology and inflammation. 30(2)