Clinical and In Vitro Resistance of Plasmodium falciparum to Artesunate-Amodiaquine in Cambodia

Autor: Saorin Kim, Chhayleang Kauy, Maria Dorina Bustos, Nimol Kloeung, Rotha Eam, Nimol Khim, Denis Mey Bouth, Sopheakvatey Ke, Brigitte Izac, Benoit Witkowski, Rithea Leang, Melissa Mairet-Khedim, Pascal Ringwald, Frédéric Ariey, Camille Marmai, Sophy Chy

Publikováno v: Clinical Infectious Diseases
Clinical Infectious Diseases, Oxford University Press (OUP), 2021, 73 (3), pp.406-413. ⟨10.1093/cid/ciaa628⟩
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Clinical Infectious Diseases, 2021, 73 (3), pp.406-413. ⟨10.1093/cid/ciaa628⟩

Background Artesunate-amodiaquine is a potential therapy for uncomplicated malaria in Cambodia. Methods Between September 2016 and January 2017, artesunate-amodiaquine efficacy and safety were evaluated in a prospective, open-label, single-arm observ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7a408552281144c8b508c0408f3cc6
https://doi.org/10.1093/cid/ciaa628

Efficacy and Safety of Pyronaridine-Artesunate plus Single-Dose Primaquine for the Treatment of Malaria in Western Cambodia

Autor: Maria Dorina Bustos, Nimol Khim, Pascal Ringwald, Benoit Witkowski, Huch Chea, Denis Mey Bouth, Rekol Huy, Melissa Mairet-Khedim, Rithea Leang

Publikováno v: Antimicrobial Agents and Chemotherapy. 63

This single-arm trial (n = 104) in western Cambodia showed high efficacy for 3-day treatment with pyronaridine-artesunate plus single-dose primaquine in Plasmodium falciparum malaria. Day 42 PCR-adjusted adequate clinical and parasitological response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5950c89fb03ea0b2f47799d1dd06a1
https://doi.org/10.1128/aac.01273-19

Efficacy and Safety of Pyronaridine-Artesunate plus Single-Dose Primaquine for Treatment of Uncomplicated

Autor: Rithea, Leang, Melissa, Mairet-Khedim, Huch, Chea, Rekol, Huy, Nimol, Khim, Denis, Mey Bouth, Maria, Dorina Bustos, Pascal, Ringwald, Benoit, Witkowski

Publikováno v: Antimicrobial agents and chemotherapy. 63(3)

In Cambodia, multidrug-resistant Plasmodium falciparum undermines the treatment of uncomplicated malaria, and new therapeutic options are needed. Pyronaridine-artesunate has not previously been evaluated in eastern Cambodia. We conducted a single-arm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e1027c631ed51b8870d70f9d1dc5939
https://pubmed.ncbi.nlm.nih.gov/30602520

Plasmodium vivax Malaria in Cambodia

Autor: Sovannaroth Siv, Arantxa Roca-Feltrer, Rekol Huy, Dysoley Lek, Jean Popovici, Seshu Babu Vinjamuri, Mohammad Abdur Rashid, Ngau Peng By, Denis Mey Bouth, Didier Menard

Publikováno v: American Journal of Tropical Medicine and Hygiene
American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2016, 95 (6 Suppl), pp.97-107. ⟨10.4269/ajtmh.16-0208⟩
The American Journal of Tropical Medicine and Hygiene

International audience; The Cambodian National Strategic Plan for Elimination of Malaria aims to move step by step toward elimination of malaria across Cambodia with an initial focus on Plasmodium falciparum malaria before achieving elimination of al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6943d5ca9ee7f5f63d29403c355025
https://hal.archives-ouvertes.fr/hal-02560609

Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010

Autor: Rashid Abdur, Didier Menard, Amy Barrette, Rithea Leang, Pascal Ringwald, Denis Mey Bouth, Socheat Duong

Publikováno v: Antimicrobial agents and chemotherapy. 57(2)

We describe here the results of antimalarial therapeutic efficacy studies conducted in Cambodia from 2008 to 2010. A total of 15 studies in four sentinel sites were conducted using dihydroartemisinin-piperaquine (DP) for the treatment of Plasmodium f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9732cebd89d0b08c16c68fe56f5f7c7f
https://pubmed.ncbi.nlm.nih.gov/23208711