Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Denis, Drainas"'
Autor:
George Kyriakopoulos, Seferina Mavroudi, Constantinos Stathopoulos, Denis Drainas, Dimitrios G. Anastasakis, Christos K. Kontos, Ilias Skeparnias, Andreas Scorilas, George D. Magoulas, Aigli Korfiati, Katerina Grafanaki, Dionissios Papaioannou, Konstantinos Theofilatos
Publikováno v:
The Pharmacogenomics Journal. 21:638-648
Retinoids are widely used in diseases spanning from dermatological lesions to cancer, but exhibit severe adverse effects. A novel all-trans-Retinoic Acid (atRA)-spermine conjugate (termed RASP) has shown previously optimal in vitro and in vivo anti-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9cfa3a4548abce64a0422e4581e8ae
https://doi.org/10.1038/s41397-021-00241-9
https://doi.org/10.1038/s41397-021-00241-9
Autor:
Denis Drainas
Publikováno v:
Antibiotics, Vol 5, Iss 2, p 15 (2016)
RNase P is an essential endonuclease in tRNA biogenesis, which generates the mature 5′-termini of tRNAs. Most forms of RNase P are ribonucleoproteins, i.e., they consist of an essential RNA and protein subunits. The catalytic function of ribonucleo
Externí odkaz:
https://doaj.org/article/916bace7845d4681bf082f6f8d41d24d
Autor:
Theodoros Petridis, Katerina Grafanaki, Christina J. Malavaki, Christos G. Kostopoulos, Dimitra Giannakopoulou, Dionissios Papaioannou, Denis Drainas, Dionysios J. Papachristou, Vassiliki Stamatopoulou, George E. Magoulas, Helen Papadaki, Stathianna Douroumi, Nikos K. Karamanos
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 107:32-44
Previous studies have shown that N(1),N(12)-bis(all-trans-retinoyl)spermine (RASP), a retinoid analog, inhibits RNase P activity and angiogenesis in the chicken embryo chorioallantoic membrane, demonstrates anti-tumor activity on prostate cancer cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5550c982df0c56c8ca3a544cd4f4cb37
https://doi.org/10.1002/bdrb.21170
https://doi.org/10.1002/bdrb.21170
Autor:
Athanasia Mouzaki, Tassos Georgakopoulos, Ioannis Panagoulias, Sofia Kallia-Raftopoulos, Denis Drainas, Dimitrios G. Anastasakis, Vassiliki Stamatopoulou, Chrisavgi Toumpeki
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 14(6)
Background RNase P-mediated cleavage of target RNAs has been proposed as a promising tool for gene silencing. Ets-2 proto-oncogene controls the expression of a wide variety of genes involved in cancer and immunity. Objective Construction of a functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b11fb99e1ccc86940e47f9bdda527d
https://pubmed.ncbi.nlm.nih.gov/29332592
https://pubmed.ncbi.nlm.nih.gov/29332592
Autor:
Anastassios Vourekas, Maria Bikou, Constantin Drainas, Chrisavgi Toumpeki, Andreas G. Tzakos, Marianthi Tsitlaidou, Denis Drainas, Amalia S. Afendra, Vassiliki Stamatopoulou
Publikováno v:
Biochemistry. 53:1810-1817
Comparative in silico analyses of bacterial RNase P enzymes clustered their RNA subunits in type A RNA, found in Escherichia coli, and in type B, found in Bacillus subtilis. Zymomonas mobilis RNase P consists of one protein (Zmo-RnpA) and one type A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be80b55c35e263b952c44ae310caa8c3
https://doi.org/10.1021/bi4011013
https://doi.org/10.1021/bi4011013
Autor:
Dimitra Hadjipavlou-Litina, Konstantinos Avgoustakis, Denis Drainas, George E. Magoulas, Dionissios Papaioannou, Stavros E. Bariamis
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:8204-8217
A series of symmetric and asymmetric spermine (SPM) conjugates with all-trans-retinoic acid (ATRA), acitretin (ACI), (E)-3-(trioxsalen-4'-yl)acrylic acid (TRAA) and L-DOPA, amides of ACI, l-DOPA and TRAA with 1-aminobutane, benzylamine, dopamine and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3f975142f5ca72bb22398a769ea8be
https://doi.org/10.1016/j.bmc.2010.10.012
https://doi.org/10.1016/j.bmc.2010.10.012
Autor:
Anastassios Vourekas, Andreas G. Tzakos, Vasiliki Stamatopoulou, Denis Drainas, Chrisavgi Toumpeki
Publikováno v:
Biochemistry. 49:10714-10727
Dictyostelium discoideum nuclear RNase P is a ribonucleoprotein complex that displays similarities with its counterparts from higher eukaryotes such as the human enzyme, but at the same time it retains distinctive characteristics. In the present stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ac8b075d751537019e05ba57b6345e
https://doi.org/10.1021/bi101297z
https://doi.org/10.1021/bi101297z
Autor:
Konstantinos Grintzalis, Adamantios Mavrakis, Vasiliki Stamatopoulou, Chrisavgi Toumpeki, Denis Drainas, Elisabeth Chroni, Stelios F Assimakopoulos, Ioannis Papapostolou, Konstantinos Faropoulos, Dimitris Konstantinou, Christos D. Georgiou
Publikováno v:
Brain Research. 1325:121-127
The development of increased oxidative stress in the context of obstructive cholestasis has been proven in various rats' organs including the brain. The present study aimed to detect alterations of tight junction-associated occludin in rat brain capi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbdc226adb9b3d794ea49ed7616c001
https://doi.org/10.1016/j.brainres.2010.02.020
https://doi.org/10.1016/j.brainres.2010.02.020
Autor:
George D. Magoulas, Christina Theodoropoulou, Olga Theodorakopoulou, Dionysios Papaioannou, Eldem Sadikoglou, Constantinos M. Athanassopoulos, Evangelia Papadimitriou, Efstathia Giannopoulou, Denis Drainas
Publikováno v:
European Journal of Medicinal Chemistry. 44:3175-3187
In the present work, a series of conjugates of amino acids with all-trans-retinoic acid (ATRA) and shorter polyene chain analogues were rationally designed, synthesized by coupling the succinimidyl active esters of the acidic retinoids with appropria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117209858a87e4c3e49866ff7fcc4352
https://doi.org/10.1016/j.ejmech.2009.03.029
https://doi.org/10.1016/j.ejmech.2009.03.029
Autor:
Alexandra Monastirli, Anastassios Vourekas, Dionysios Tsambaos, Chrisavgi Toumpeki, Denis Drainas, Vasiliki Stamatopoulou, Eleftheria Vryzaki
Publikováno v:
Experimental Dermatology. 18:130-133
Ribonuclease P (RNase P) is ubiquitous and essential Mg(2+)-dependent endoribonuclease that catalyzes the 5'-maturation of transfer RNAs. RNase P and the ribosome are so far the only ribozymes known to be conserved in all kingdoms of life. Eukaryotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2afebb626775ccd9bead33d59c816a7e
https://doi.org/10.1111/j.1600-0625.2008.00772.x
https://doi.org/10.1111/j.1600-0625.2008.00772.x