Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function

Autor: Denis Dacheux, Guillaume Martinez, Christine E Broster Reix, Julie Beurois, Patrick Lores, Magamba Tounkara, Jean-William Dupuy, Derrick Roy Robinson, Corinne Loeuillet, Emeline Lambert, Zeina Wehbe, Jessica Escoffier, Amir Amiri-Yekta, Abbas Daneshipour, Seyedeh-Hanieh Hosseini, Raoudha Zouari, Selima Fourati Ben Mustapha, Lazhar Halouani, Xiaohui Jiang, Ying Shen, Chunyu Liu, Nicolas Thierry-Mieg, Amandine Septier, Marie Bidart, Véronique Satre, Caroline Cazin, Zine Eddine Kherraf, Christophe Arnoult, Pierre F Ray, Aminata Toure, Mélanie Bonhivers, Charles Coutton

Publikováno v: eLife, Vol 12 (2023)

Male infertility is common and complex, presenting a wide range of heterogeneous phenotypes. Although about 50% of cases are estimated to have a genetic component, the underlying cause often remains undetermined. Here, from whole-exome sequencing on

Externí odkaz: https://doaj.org/article/2b37a6175cab4e93a36110639ca35769

Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human

Autor: Charles Coutton, Alexandra S. Vargas, Amir Amiri-Yekta, Zine-Eddine Kherraf, Selima Fourati Ben Mustapha, Pauline Le Tanno, Clémentine Wambergue-Legrand, Thomas Karaouzène, Guillaume Martinez, Serge Crouzy, Abbas Daneshipour, Seyedeh Hanieh Hosseini, Valérie Mitchell, Lazhar Halouani, Ouafi Marrakchi, Mounir Makni, Habib Latrous, Mahmoud Kharouf, Jean-François Deleuze, Anne Boland, Sylviane Hennebicq, Véronique Satre, Pierre-Simon Jouk, Nicolas Thierry-Mieg, Beatrice Conne, Denis Dacheux, Nicolas Landrein, Alain Schmitt, Laurence Stouvenel, Patrick Lorès, Elma El Khouri, Serge P. Bottari, Julien Fauré, Jean-Philippe Wolf, Karin Pernet-Gallay, Jessica Escoffier, Hamid Gourabi, Derrick R. Robinson, Serge Nef, Emmanuel Dulioust, Raoudha Zouari, Mélanie Bonhivers, Aminata Touré, Christophe Arnoult, Pierre F. Ray

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)

Asthenozoospermia is a major cause of male infertility, and multiple morphological abnormalities of the flagella (MMAF) is a particularly severe form. Here, using whole-exome sequencing of 78 MMAF patients, the authors identify mutations in two WDR p

Externí odkaz: https://doaj.org/article/03b883f351d94cb6999191bf43221e62

Bronchial epithelia from adults and children: SARS-CoV-2 spread via syncytia formation and type III interferon infectivity restriction

Autor: Guillaume Beucher, Marie-Lise Blondot, Alexis Celle, Noémie Pied, Patricia Recordon-Pinson, Pauline Esteves, Muriel Faure, Mathieu Métifiot, Sabrina Lacomme, Denis Dacheux, Derrick R. Robinson, Gernot Längst, Fabien Beaufils, Marie-Edith Lafon, Patrick Berger, Marc Landry, Denis Malvy, Thomas Trian, Marie-Line Andreola, Harald Wodrich

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (28), ⟨10.1073/pnas.2202370119⟩

International audience; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections initiate in the bronchi of the upper respiratory tract and are able to disseminate to the lower respiratory tract, where infections can cause an acute res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0d2eef99823f2ac361a27dc432c3a3
https://doi.org/10.1073/pnas.2202370119

Correction: Murine Models for Trypanosoma brucei gambiense Disease Progression-From Silent to Chronic Infections and Early Brain Tropism.

Autor: Christiane Giroud, Florence Ottones, Virginie Coustou, Denis Dacheux, Nicolas Biteau, Benjamin Miezan, Nick Van Reet, Mark Carrington, Felix Doua, Théo Baltz

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 4, p e0004645 (2016)

Externí odkaz: https://doaj.org/article/c24f266e9f284057a586358a403a2313

Intrabody-Induced Cell Death by Targeting the T. brucei Cytoskeletal Protein TbBILBO1

Autor: Carmelo Di Primo, Laetitia Minder, Denis Dacheux, Miharisoa Rijatiana Ramanantsalama, Derrick R. Robinson, Christine E. Broster Reix, Mélanie Bonhivers

Publikováno v: Microbiology Spectrum, Vol 9, Iss 2 (2021)
Microbiology Spectrum
Microbiology Spectrum, 2021, 9 (2), ⟨10.1128/Spectrum.00915-21⟩

International audience; Trypanosoma brucei belongs to a genus of protists that cause life-threatening and economically important diseases of human and animal populations in Sub-Saharan Africa. T. brucei cells are covered in surface glycoproteins, som

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35541c8bbb5836d286711b07b31fe8dd
https://journals.asm.org/doi/10.1128/Spectrum.00915-21