Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Denice T. Y. Chan"'
Autor:
Elizabeth England, D. Gareth Rees, Ian Christopher Scott, Sara Carmen, Denice T. Y. Chan, Catherine E. Chaillan Huntington, Kirsty F. Houslay, Teodor Erngren, Mark Penney, Jayesh B. Majithiya, Laura Rapley, Dorothy A. Sims, Claire Hollins, Elizabeth C. Hinchy, Martin D. Strain, Benjamin P. Kemp, Dominic J. Corkill, Richard D. May, Katherine A. Vousden, Robin J. Butler, Tomas Mustelin, Tristan J. Vaughan, David C. Lowe, Caroline Colley, E. Suzanne Cohen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory responses following tissue damage or infection and is a promising target for treatment of inflammatory disease. Here, we describe the identification of tozora
Externí odkaz:
https://doaj.org/article/4d1e1f2da3f148aa85e1df6a32f0ef69
Autor:
Elizabeth England, D. Gareth Rees, Ian Christopher Scott, Sara Carmen, Denice T. Y. Chan, Catherine E. Chaillan Huntington, Kirsty F. Houslay, Teodor Erngren, Mark Penney, Jayesh B. Majithiya, Laura Rapley, Dorothy A. Sims, Claire Hollins, Elizabeth C. Hinchy, Martin D. Strain, Benjamin P. Kemp, Dominic J. Corkill, Richard D. May, Katherine A. Vousden, Robin J. Butler, Tomas Mustelin, Tristan J. Vaughan, David C. Lowe, Caroline Colley, E. Suzanne Cohen
Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory responses following tissue damage or infection and is a promising target for treatment of inflammatory disease. Here, we describe the identification of tozorakimab (ME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2623b7a64721c16cead1782c6553f513
https://doi.org/10.1101/2023.02.28.527262
https://doi.org/10.1101/2023.02.28.527262
Autor:
Maria A T Groves, Denice T Y Chan
Publikováno v:
Emerging Topics in Life Sciences
Affinity maturation is a key technique in protein engineering which is used to improve affinity and binding interactions in vitro, a process often required to fulfil the therapeutic potential of antibodies. There are many available display technologi
Autor:
Ellen Gowans, Stuart W. Haynes, Mark D. Carr, Stephanie Ryman, Maria A T Groves, Daniel Burschowsky, Tristan J Vaughan, Alexandra Addyman, Vincenzo Cerundolo, Agata Diamandakis, Chitra Seewooruthun, Yoko Shibata, Louise H. Slater, Sarah V. Holt, Denice T Y Chan, Sebastian Fiedler, Jessica Whitehouse, Robert W. Wilkinson, Lesley Jenkinson, Mark Austin, Michelle Barnard
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We describe an antibody optimization strategy that seeks to overcome the restrictive nature of existing affinity-maturation methods, by rapidly exploring a vast sequence space in an unbiased manner through application of PCR techniques a
Autor:
Jessica Whitehouse, Mark D. Carr, Lesley Jenkinson, Daniel Burschowsky, Pooja Sharma, Teresa Kaserer, Mark Austin, Yoko Shibata, Michelle Barnard, Sebastian Fiedler, Alexandra Addyman, Denice T Y Chan, Uzi Gileadi, Tristan J Vaughan, Vincenzo Cerundolo, Stuart W. Haynes, Andreas V. Hadjinicolaou, Robert W. Wilkinson, Nadia Luheshi, Ellen Gowans, Stephanie Ryman, Chitra Seewooruthun, Louise H. Slater, Maria A T Groves, Sarah V. Holt, Agata Diamandakis
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 within specific tumor microenvironments generates an immunosuppressive niche that effectively renders the tumor
Autor:
Dorothy A. Sims, Richard D. May, Tomas Mustelin, Joanne Woods, David C. Lowe, Denice T. Y. Chan, Laura Rapley, Benjamin Kemp, Matthew A. Sleeman, Nicholas J. Bond, Christel Séguy Veyssier, Liz Flavell, Katherine A. Vousden, Tristan J. Vaughan, Sara Carmen, Kevin J. Embrey, Overed-Sayer Catherine L, Catherine E. Huntington, Christopher E. Brightling, Michael R. Snaith, Bojana Popovic, D. Gareth Rees, Strain Martin D, Ian C. Scott, E. Suzanne Cohen, Jianqing Xu, Dominic J. Corkill, Jayesh B. Majithiya, Daniel R. Higazi, Elizabeth England, Robin Butler
Publikováno v:
Nature Communications
In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin (IL)-33 to elicit a rapid immune response. However, little is known about the regulation of IL-33 following its release. Here we report that the biol