Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Denia Frank"'
Autor:
Marco J. Rotter, Sabrina Zentgraf, Lilia Weizel, Denia Frank, Luisa D. Burgers, Steffen Brunst, Robert Fürst, Anna Proschak, Thomas A. Wichelhaus, Ewgenij Proschak
Publikováno v:
Molecules, Vol 28, Iss 4, p 1984 (2023)
Metallo beta lactamases (MBLs) are among the most problematic resistance mechanisms of multidrug-resistant Gram-negative pathogens due to their broad substrate spectrum and lack of approved inhibitors. In this study, we propose the integration of cat
Externí odkaz:
https://doaj.org/article/07a6b9920e1345b4853cd0c20978c4c0
Autor:
Cansu Kaya, Jelena Konstantinović, Andreas M. Kany, Anastasia Andreas, Jan S. Kramer, Steffen Brunst, Lilia Weizel, Marco J. Rotter, Denia Frank, Samir Yahiaoui, Rolf Müller, Rolf W. Hartmann, Jörg Haupenthal, Ewgenij Proschak, Thomas A. Wichelhaus, Anna K. H. Hirsch
Publikováno v:
Journal of Medicinal Chemistry. 65:3913-3922
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba2b5b359b69016b19595f2e0d6c1f7
https://doi.org/10.1021/acs.jmedchem.1c01755
https://doi.org/10.1021/acs.jmedchem.1c01755
Autor:
Ewgenij Proschak, Anna Proschak, Darina Barkhatova, Igor Solovyev, Thomas A. Wichelhaus, Dmitry Dar'in, Mikhail Krasavin, Steffen Brunst, Denia Frank, Lilia Weizel, Jan S. Kramer, Marco Rotter, Daniil Zhukovsky, Giada Martinelli
Publikováno v:
ChemMedChem. 16:3410-3417
Diversity-oriented synthesis (DOS) is a rich source for novel lead structures in Medicinal Chemistry. In this study, we present a DOS-compatible method for synthesis of compounds bearing a free thiol moiety. The procedure relies on Rh(II)-catalyzed c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::380e9a3eadcbc04a0052bb816a8cf256
https://doi.org/10.1002/cmdc.202100344
https://doi.org/10.1002/cmdc.202100344
Autor:
Jan S. Kramer, Marco Rotter, Samir Yahiaoui, Anna K. H. Hirsch, Ewgenij Proschak, Denia Frank, Jörg Haupenthal, Christian Ducho, Steffen Brunst, Katrin Voos, Lilia Weizel, Thomas A. Wichelhaus
Publikováno v:
RSC Medicinal Chemistry
Increasing antimicrobial resistance is evolving to be one of the major threats to public health. To reduce the selection pressure and thus to avoid a fast development of resistance, novel approaches aim to target bacterial virulence instead of growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d9438f774a6964ea1e08e571176266
https://doi.org/10.1039/d1md00187f
https://doi.org/10.1039/d1md00187f
Autor:
Mikhail, Krasavin, Daniil, Zhukovsky, Igor, Solovyev, Darina, Barkhatova, Dmitry, Dar'in, Denia, Frank, Giada, Martinelli, Lilia, Weizel, Anna, Proschak, Marco, Rotter, Jan S, Kramer, Steffen, Brunst, Thomas A, Wichelhaus, Ewgenij, Proschak
Publikováno v:
ChemMedChem. 16(22)
Diversity-oriented synthesis (DOS) is a rich source for novel lead structures in Medicinal Chemistry. In this study, we present a DOS-compatible method for synthesis of compounds bearing a free thiol moiety. The procedure relies on Rh(II)-catalyzed c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::45be389f0bb2a405135bb87ccdcf1fbe
https://pubmed.ncbi.nlm.nih.gov/34184833
https://pubmed.ncbi.nlm.nih.gov/34184833
Autor:
Anna Proschak, Denia Frank, Steffen Brunst, Izidor Sosič, Thomas A. Wichelhaus, Stanislav Gobec, Robert Fürst, Luisa D. Burgers, Ewgenij Proschak, Marco Rotter, Giada Martinelli, Lilia Weizel
Publikováno v:
European journal of medicinal chemistry, str. 1-10 : Ilustr., Vol. 228, 2022
COBISS-ID: 25429760
COBISS-ID: 25429760
Carbapenemases such as metallo-[beta]-lactamases (MBLs) are spreading among Gram-negative bacterial pathogens. Infections due to these multidrug-resistant bacteria constitute a major global health challenge. Therapeutic strategies against carbapenema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747b900477f826416d4a9d6bb3411311
https://doi.org/10.1016/j.ejmech.2021.113975
https://doi.org/10.1016/j.ejmech.2021.113975
Autor:
Daniil Zhukovsky, Giada Martinelli, Jan S. Kramer, Denia Frank, Thomas A. Wichelhaus, Dmitry Dar'in, Marco Rotter, Anna Proschak, Lilia Weizel, Mikhail Krasavin, Ewgenij Proschak, Darina Barkhatova, Steffen Brunst, Igor Solovyev
Publikováno v:
ChemMedChem. 16:3375-3375
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3f49ab7ad1f5ea17b15e760b50e0db5
https://doi.org/10.1002/cmdc.202100692
https://doi.org/10.1002/cmdc.202100692
Autor:
Daniel Kohnhäuser, Markus Hartmann, Denia Frank, Sandra K. Wittmann, Dominik Büttner, Thomas A. Wichelhaus, Jan S. Kramer, Denys Pogoryelov, Christian Kurz, Lilia Weizel, Franca Maria Klingler, Astrid Brüggerhoff, Dieter Steinhilber, Ewgenij Proschak
Publikováno v:
ACS Infectious Diseases. 4:360-372
Pathogens, expressing metallo-β-lactamases (MBLs), become resistant against most β-lactam antibiotics. Besides the dragging search for new antibiotics, development of MBL inhibitors would be an alternative weapon against resistant bacterial pathoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9de5e8d4b7097a7a3ca2b01004426c5
https://doi.org/10.1021/acsinfecdis.7b00129
https://doi.org/10.1021/acsinfecdis.7b00129
Autor:
Michael Hogardt, Thomas A. Wichelhaus, Stephan Göttig, Anika Nolte, Denia Frank, Eleonora Mungo, Silke Besier
Publikováno v:
The Journal of antimicrobial chemotherapy. 74(11)
ObjectivesThe β-lactam/β-lactamase inhibitor combination ceftazidime/avibactam is active against KPC-producing Enterobacterales. Herein, we present molecular and phenotypic characterization of ceftazidime/avibactam resistance in KPC-3-producing Kle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa40829576f381fd67f44ed0b485c8b
https://pubmed.ncbi.nlm.nih.gov/31365094
https://pubmed.ncbi.nlm.nih.gov/31365094
Autor:
Andreas Vilcinskas, Simone Eckstein, Virginie Lecaudey, Tien Duy Vo, Sebastian L Wenski, Reuel Bennet, Svenja Simonyi, Marco Thines, Harun Cimen, Wilhelm Schäfer, Ralf Heermann, Eckhard Thines, Yi-Ming Shi, Antje K. Heinrich, Peter Grün, Gerd Geisslinger, Nadine Keller, Desalegne Abebew, Susanne Schiffmann, Yvonne Engel, Thomas A. Wichelhaus, Martin Gand, Robert Fürst, Merle Hirschmann, Anthony Buaya, Marina Henke, Ibrahim Cakmak, Yan-Ni Shi, Rebecca Schwenk, Marisa Skaljac, Edna Bode, Sophie Beyer, Thomas Ulshöfer, Frank Wesche, Helge B. Bode, Anja Schüffler, Selcuk Hazir, Sophie C. Brandt, Iris Bischoff, Denia Frank
Publikováno v:
Angewandte Chemie (International Ed. in English)
Natural products (NPs) from microorganisms have been important sources for discovering new therapeutic and chemical entities. While their corresponding biosynthetic gene clusters (BGCs) can be easily identified by gene‐sequence‐similarity‐based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d31932f9e864a5d8616fe5fa1bb81c
https://publica.fraunhofer.de/handle/publica/267528
https://publica.fraunhofer.de/handle/publica/267528
