Increased Actin Binding Is a Shared Molecular Consequence of Numerous SCA5 Mutations in β-III-Spectrin.

Autor: Atang AE; Department of Chemistry, Oakland University, Rochester, MI 48309, USA., Keller AR; Department of Chemistry, Oakland University, Rochester, MI 48309, USA., Denha SA; Department of Chemistry, Oakland University, Rochester, MI 48309, USA., Avery AW; Department of Chemistry, Oakland University, Rochester, MI 48309, USA.

Publikováno v: Cells [Cells] 2023 Aug 19; Vol. 12 (16). Date of Electronic Publication: 2023 Aug 19.

Early-phase drug discovery of β-III-spectrin actin-binding modulators for treatment of spinocerebellar ataxia type 5.

Autor: Guhathakurta P; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Rebbeck RT; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Denha SA; Department of Chemistry, Oakland University, Rochester, Michigan, USA., Keller AR; Department of Chemistry, Oakland University, Rochester, Michigan, USA., Carter AL; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Atang AE; Department of Chemistry, Oakland University, Rochester, Michigan, USA., Svensson B; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Thomas DD; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Hays TS; Department of Genetics, Cellular Biology, and Development, University of Minnesota, Minneapolis, Minnesota, USA., Avery AW; Department of Chemistry, Oakland University, Rochester, Michigan, USA. Electronic address: awavery@oakland.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2023 Mar; Vol. 299 (3), pp. 102956. Date of Electronic Publication: 2023 Jan 31.

Novel drug discovery platform for spinocerebellar ataxia, using fluorescence technology targeting β-III-spectrin.

Autor: Rebbeck RT; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Andrick AK; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Denha SA; Department of Chemistry, Oakland University, Rochester, Michigan, USA., Svensson B; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Guhathakurta P; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Thomas DD; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Hays TS; Department of Genetics, Cellular Biology, and Development, University of Minnesota, Minneapolis, Minnesota, USA., Avery AW; Department of Chemistry, Oakland University, Rochester, Michigan, USA; Department of Genetics, Cellular Biology, and Development, University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: awavery@oakland.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100215. Date of Electronic Publication: 2020 Dec 24.