Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Dengqi, Xue"'
Publikováno v:
In European Journal of Medicinal Chemistry 5 January 2023 245 Part 2
Publikováno v:
Journal of Medicinal Chemistry. 65:11658-11678
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::289db10af1c3a1ad6e8897516957e845
https://doi.org/10.1021/acs.jmedchem.2c00469
https://doi.org/10.1021/acs.jmedchem.2c00469
Autor:
Siyu Song, Xiangshuo Ouyang, Dengqi Xue, KeWei Wang, Heling Niu, Liying Dong, Yani Liu, Liming Shao, Denggao Zhang, Yilin Zheng, Qianwei Ge
Publikováno v:
Chinese Chemical Letters. 33:1643-1646
Three novel series of α-aminoamides derivatives were designed and synthesized based on ralfinamide, and their Nav1.7 inhibitory activities were evaluated using manual patch clamp electrophysiology. Active compounds inhibited Nav1.7 with half maximal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d87ffe13959837c81ec6efdc5ce4d01d
https://doi.org/10.1016/j.cclet.2021.08.026
https://doi.org/10.1016/j.cclet.2021.08.026
Autor:
Yani Liu, An-ruo Zou, Huijie Liu, Liming Shao, Jing Wang, Dengqi Xue, Yilin Zheng, Li-ying Dong, KeWei Wang, Heling Niu
Publikováno v:
Acta Pharmacol Sin
Voltage-gated sodium channel Nav1.7 robustly expressed in peripheral nociceptive neurons has been considered as a therapeutic target for chronic pain, but there is no selective Nav1.7 inhibitor available for therapy of chronic pain. Ralfinamide has s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca4bd673db2440b09124b2449a2a49b
https://doi.org/10.1038/s41401-021-00682-9
https://doi.org/10.1038/s41401-021-00682-9
Autor:
Xiangshuo Ouyang, Min Su, Dengqi Xue, Liying Dong, Heling Niu, Wei Li, Yani Liu, KeWei Wang, Liming Shao
Publikováno v:
Bioorganic & Medicinal Chemistry. 86:117290
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b3a755207bc711e2cbda593e8e98529
https://doi.org/10.1016/j.bmc.2023.117290
https://doi.org/10.1016/j.bmc.2023.117290
Publikováno v:
Organic & Biomolecular Chemistry. 19:8597-8606
An iron-catalyzed radical cascade cyclization of oxime esters with isocyanides for the synthesis of 1-cyanoalkyl isoquinolines and 6-cyanoalkyl phenanthridines has been developed. This demonstrates excellent functional group tolerance and broad subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafae5d6b2f5487081b2d7f012c1b285
https://doi.org/10.1039/d1ob01556g
https://doi.org/10.1039/d1ob01556g
Publikováno v:
The Journal of Organic Chemistry. 85:12284-12293
A variety of dihydropyrrole-functionalized phenanthridines were efficiently synthesized by the metal-free, radical cascade cyclization reaction of 2-isocyanobiphenyls with γ,δ-unsaturated oxime esters. The C-N/C-C/C-C bonds were formed via the oil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca7cd9b97dc710bf85b88053fe7d886
https://doi.org/10.1021/acs.joc.0c01532
https://doi.org/10.1021/acs.joc.0c01532
Autor:
Caiyan Tian, Luisa Speicher, Dengqi Xue, David Moreno-González, Ulrich Marggraf, Norman Ahlmann, Sebastian Brandt, Joachim Franzke, Guanghui Niu
Publikováno v:
Talanta. 249:123662
Non-thermal plasma-based ionization sources have been widely used and shown excellent soft ionization performance in mass spectrometry. Despite their extensive application, the ionization mechanisms of these sources are of great interest for further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e2f3bdf1dc6c2a5f4d32a3d0624702
https://doi.org/10.1016/j.talanta.2022.123662
https://doi.org/10.1016/j.talanta.2022.123662
Autor:
Yuanyuan Qian, Yilin Zheng, Lan Zheng, Xicheng Yang, Wei Li, Xue-Jun Xu, Mumei Zhang, Qian He, Huoming Huang, Xiao Liu, Ru-Feng Ye, Zhuibai Qiu, Congmin Yuan, Cheng Lin, Hao Chen, Rongrong Ye, Shuang Jiang, Huijiao Sun, Linqian Yu, Wei-Wei Wu, Yujun Wang, Linghui Kong, Liming Shao, Wei Fu, Dengqi Xue, Yan Ma, Qiong Xie, Hai-hao Wu, Jing-Gen Liu, Li Xiao, Shengyang Fang
Publikováno v:
Journal of Medicinal Chemistry. 62:11054-11070
Effective and safe analgesics represent an unmet medical need for the treatment of acute and chronic pain. A series of N-cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaines were designed, synthesized, and assayed, leading to the discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f428c9fb80b3279f72fe55ee02b21dd7
https://doi.org/10.1021/acs.jmedchem.9b00857
https://doi.org/10.1021/acs.jmedchem.9b00857
Publikováno v:
Tetrahedron. 121:132927
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba65e24ad091891b92addcf1dd7d781c
https://doi.org/10.1016/j.tet.2022.132927
https://doi.org/10.1016/j.tet.2022.132927