Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Dengke K. Ma"'
Autor:
Taruna Pandey, Bingying Wang, Changnan Wang, Jenny Zu, Huichao Deng, Kang Shen, Goncalo Dias do Vale, Jeffrey G. McDonald, Dengke K. Ma
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113899- (2024)
Summary: Insulin-mechanistic target of rapamycin (mTOR) signaling drives anabolic growth during organismal development; its late-life dysregulation contributes to aging and limits lifespans. Age-related regulatory mechanisms and functional consequenc
Externí odkaz:
https://doaj.org/article/1e0b0fedb050458094eefe0da06f226a
Autor:
Ruina Wang, Lei Xiao, Jianbo Pan, Guangsen Bao, Yunmei Zhu, Di Zhu, Jun Wang, Chengfeng Pei, Qinfeng Ma, Xian Fu, Ziruoyu Wang, Mengdi Zhu, Guoxiang Wang, Ling Gong, Qiuping Tong, Min Jiang, Junchi Hu, Miao He, Yun Wang, Tiejun Li, Chunmin Liang, Wei Li, Chunmei Xia, Zengxia Li, Dengke K. Ma, Minjia Tan, Jun Yan Liu, Wei Jiang, Cheng Luo, Biao Yu, Yongjun Dang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme environmental conditions. However, pharmacological induction of hypothermia in most mammals remains a huge challenge. Here we show that a nat
Externí odkaz:
https://doaj.org/article/994188ebcab5466fab11651b85358e5d
Autor:
Kathy H. Li, Bingying Wang, Roman Vozdek, Andrew A. Hicks, Peter P. Pramstaller, Dengke K. Ma
Publikováno v:
Open Research Europe, Vol 2 (2023)
Background: Parkin, which when mutated leads to early-onset Parkinson’s disease, acts as an E3 ubiquitin ligase. How Parkin is regulated for selective protein and organelle targeting is not well understood. Here, we used protein interactor and gene
Externí odkaz:
https://doaj.org/article/89e4ea6c0f934c1dbba1b4ba7c10fabe
Autor:
Changnan Wang, Bingying Wang, Taruna Pandey, Yong Long, Jianxiu Zhang, Fiona Oh, Jessica Sima, Ruyin Guo, Yun Liu, Chao Zhang, Shaeri Mukherjee, Michael Bassik, Weichun Lin, Huichao Deng, Goncalo Vale, Jeffrey G. McDonald, Kang Shen, Dengke K. Ma
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Environmental temperature changes can alter cell membrane lipid composition but the mechanisms underlying this conserved mechanism are unclear. Here, the authors identify the megaprotein LPD-3 in C. elegans as critical for normal phospholipid distrib
Externí odkaz:
https://doaj.org/article/2d75115bb2a9473887c9c5ba2658996d
Publikováno v:
Contact, Vol 6 (2023)
In eukaryotic cells, lipid transfer can occur at membrane contact sites (MCS) to facilitate the exchange of various lipids between two adjacent cellular organelle membranes. Lipid transfer proteins (LTPs), including shuttle LTP or bridge-like LTP (BL
Externí odkaz:
https://doaj.org/article/a5878d8e45034411951c435916b0f111
Autor:
Renke Tan, Wenhao Du, Yiyang Liu, Xiaoji Cong, Meirong Bai, Chenxiao Jiang, Zengxia Li, Minjia Tan, Dengke K. Ma, Qiang Huang, Wei Jiang, Yongjun Dang
Publikováno v:
Genes and Diseases, Vol 9, Iss 3, Pp 731-740 (2022)
The CRISPR/Cas9 system, originally derived from the prokaryotic adaptive immune system, has been developed as efficient genome editing tools. It enables precise gene manipulation on chromosomal DNA through the specific binding of programmable sgRNA t
Externí odkaz:
https://doaj.org/article/fabaa232c68f47d8a876a1db7b2ba62d
Autor:
Xin Wang, Wei Jiang, Shuo Luo, Xiaoyu Yang, Changnan Wang, Bingying Wang, Yongjun Dang, Yin Shen, Dengke K. Ma
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract TMEM132D is a human gene identified with multiple risk alleles for panic disorders, anxiety and major depressive disorders. Defining a conserved family of transmembrane proteins, TMEM132D and its homologs are still of unknown molecular funct
Externí odkaz:
https://doaj.org/article/7356d52aa2524134b2ea8cd225fbc048
Publikováno v:
Protein & Cell, Vol 10, Iss 8, Pp 610-614 (2019)
Externí odkaz:
https://doaj.org/article/80146476d19344569889c9c9f379de8c
Autor:
Zhaofa Xu, Yiman Hu, Yajun Deng, Yutao Chen, Hanqi Hua, Siyu Huang, Qian Nie, Qian Pan, Dengke K. Ma, Long Ma
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 11, Pp 3515-3527 (2018)
Animals utilize conserved mechanisms to regulate oxidative stress. The C. elegans SKN-1 protein is homologous to the vertebrate Nrf (NF-E2-related factor) family of cap ’n’ collar (CnC) transcription factors and functions as a core regulator of x
Externí odkaz:
https://doaj.org/article/d7c38382648942e1a64519b83358ebda
Autor:
Meirong Bai, Roman Vozdek, Aleš Hnízda, Chenxiao Jiang, Bingying Wang, Ladislav Kuchar, Tiejun Li, Yuefan Zhang, Chase Wood, Liang Feng, Yongjun Dang, Dengke K. Ma
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
MANF is a secreted ER stress-inducible protein that protects neurons, pancreatic β cells and cardiomyocytes from cell death under oxidative stress, hypoxic or ischemic conditions. Here the authors show that MANF confers cytoprotection through direct
Externí odkaz:
https://doaj.org/article/3cf989f2d1324ba5867f71eac528a672