Zobrazeno 1 - 10
of 395
pro vyhledávání: '"Dendritic spine morphogenesis"'
Autor:
Zhi-Hui Yang, Xin Cai, Zhong-Li Ding, Wei Li, Chu-Yi Zhang, Jin-Hua Huo, Yue Zhang, Lu Wang, Lin-Ming Zhang, Shi-Wu Li, Ming Li, Chen Zhang, Hong Chang, Xiao Xiao
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background Schizophrenia and bipolar disorder (BD) are believed to share clinical symptoms, genetic risk, etiological factors, and pathogenic mechanisms. We previously reported that single nucleotide polymorphisms spanning chromosome 3p21.1
Externí odkaz:
https://doaj.org/article/87ea1fa31ead4449991435132ff5af5a
Akademický článek
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Publikováno v:
The Journal of Cell Biology, 2003 Dec . 163(6), 1313-1326.
Externí odkaz:
https://www.jstor.org/stable/1622020
Autor:
Xiaotao Duan, Yan Wu, Zhe Zhao, Liping Chen, Juanxian Cheng, Qian Zhu, Haitao Wu, Ying Li, Ruijing Du, Ming Fan
Publikováno v:
Neurosci Bull
Mutations of the X-linked methyl-CpG-binding protein 2 (MECP2) gene in humans are responsible for most cases of Rett syndrome (RTT), an X-linked progressive neurological disorder. While genome-wide screens in clinical trials have revealed several put
Autor:
Małgorzata Drozd, Maria Capovilla, Florence Askenazy, Susanne Thümmler, Arnaud Fernandez, Barbara Bardoni
Publikováno v:
American Journal of Medical Genetics Part A
American Journal of Medical Genetics Part A, Wiley, 2021, 185 (6), pp.1841-1847. ⟨10.1002/ajmg.a.62155⟩
American Journal of Medical Genetics Part A, Wiley, 2021, 185 (6), pp.1841-1847. ⟨10.1002/ajmg.a.62155⟩
Childhood-Onset Schizophrenia (COS) is a very rare and severe psychiatric disorder defined by adult schizophrenia symptoms occurring before the age of 13. We report a microduplication in the 10q26.3 region including part of the Inositol Polyphosphate
Autor:
Louisa Hoi-Ying Lo, Kwok On Lai
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-9 (2020)
Molecular Autism
Molecular Autism
Autism spectrum disorder (ASD) is a brain disorder that involves changes in neuronal connections. Abnormal morphology of dendritic spines on postsynaptic neurons has been observed in ASD patients and transgenic mice that model different monogenetic c
Autor:
Wasco Wruck, James Adjaye
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-18 (2020)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Despite ongoing research efforts, mechanisms of brain aging are still enigmatic and need to be elucidated for a better understanding of age-associated cognitive decline. The aim of this study is to investigate aging in the prefrontal cortex region of
Autor:
Shuangshuang Ma, Yijing Chen, Jiali Wang, Saijuan Liu, Lin Yuan, Yu Chen, Wanying Yi, Yuewen Chen, Changyu Sun
Publikováno v:
Biochemical and biophysical research communications. 584
Dendritic spines are the postsynaptic structure to mediate signal transduction in neural circuitry, whose function and plasticity are regulated by organization of their molecular architecture and by the expression of target genes and proteins. EphB2,
Autor:
Mattia Gentile, Patrizia D'Adamo, Alessandra Gabellone, Lucia Margari, Susanna Gelmini, Romina Ficarella, Antonia Peschechera, Lucia Marzulli, Maria Lidia Mignogna, Emanuela Ponzi, Massino Alessio
Publikováno v:
Human molecular genetics. 31(9)
Autism spectrum disorder (ASD) and intellectual disability (ID) often exist together in patients. The RAB39B gene has been reported to be mutated in ID patients with additional clinical features ranging from ASD, macrocephaly, seizures and/or early-o
Autor:
Kosuke Higashino, Atsuko Hayata-Takano, Kaoru Seiriki, Toshihiko Kamo, Harui Kijima, Takanobu Nakazawa, Yukio Ago, Atsushi Kasai, James A. Waschek, Kazuki Nagayasu, Norihito Shintani, Katsuya Ogata, Hitoshi Hashimoto, Yusuke Shintani
Publikováno v:
The Journal of Neuroscience. 39:4208-4220
Alterations in pituitary adenylate cyclase-activating polypeptide (PACAP), a multifunctional neuropeptide, and its receptors have been identified as risk factors for certain psychiatric disorders, including schizophrenia. Increasing evidence from hum