Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Dendritic spine head"'
Autor:
Raksha Ramdas, Emily H. Poovey, Kelsey R. Clearman, Courtney K. Walker, Benjamin D. Boros, Kelsey M. Greathouse, Hamad M. Muhammad, Jeremy H. Herskowitz
Publikováno v:
Neuroscience
Synapse or dendritic spine loss is the strongest correlate of cognitive decline in Alzheimer’s disease (AD), and neurofibrillary tangles (NFTs), but not amyloid-β plaques, associate more closely with transition to mild cognitive impairment. Yet, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7399d1072fcd865cd63523aa79551505
https://doi.org/10.1016/j.neuroscience.2020.12.006
https://doi.org/10.1016/j.neuroscience.2020.12.006
Autor:
Meghan Kerrisk Campbell, William J. Brunken, Charles A. Greer, Jeffrey H. Miner, Mitchell H. Omar, Anthony J. Koleske, Xiao Xiao, Qiaonan Zhong
Publikováno v:
Cell reports
Cell Reports, Vol 21, Iss 5, Pp 1281-1292 (2017)
Cell Reports, Vol 21, Iss 5, Pp 1281-1292 (2017)
SUMMARY Synapses in the developing brain are structurally dynamic but become stable by early adulthood. We demonstrate here that an α5-subunit-containing laminin stabilizes synapses during this developmental transition. Hippocampal neurons deposit l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba549000ee22a227c984a04d97d2a36
http://europepmc.org/articles/PMC5776391
http://europepmc.org/articles/PMC5776391
Publikováno v:
Brain Structure and Function. 221:1681-1689
Animal models of relapse reveal that the motivation to seek drug is regulated by enduring morphological and physiological changes in the nucleus accumbens, as well as transient synaptic potentiation in the accumbens core (NAcore) that parallels drug-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbbe2b3a9d88a8bff30490ecec0fc29
https://doi.org/10.1007/s00429-015-0997-8
https://doi.org/10.1007/s00429-015-0997-8
Publikováno v:
Movement Disorders
Parkinson's disease (PD) is a neurodegenerative disorder associated with the progressive loss of nigrostriatal dopaminergic neurons. Levodopa is the most effective treatment for the motor symptoms of PD. However, chronic oral levodopa treatment can l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54f2146efae4cbabb5f10791fa189ff
https://pubmed.ncbi.nlm.nih.gov/28880414
https://pubmed.ncbi.nlm.nih.gov/28880414
Autor:
Neringa Stankeviciute, Yonatan M. Kupchik, Alexander C.W. Smith, Cassandra D. Gipson, Kathryn J. Reissner, Megan E. Hensley-Simon, Peter W. Kalivas
Publikováno v:
Proceedings of the National Academy of Sciences. 110:9124-9129
Nicotine abuse and addiction is a major health liability. Nicotine, an active alkaloid in tobacco, is self-administered by animals and produces cellular adaptations in brain regions associated with drug reward, such as the nucleus accumbens. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633f36824d3fff7a70e236dcbd073674
https://doi.org/10.1073/pnas.1220591110
https://doi.org/10.1073/pnas.1220591110
Autor:
Takashi Iwakura, Keiko Moriya-Ito, Masumi Ichikawa, Atsuhiro Tsutiya, Ritsuko Ohtani-Kaneko, Yue Wu
Publikováno v:
Neuroscience Letters. 500:77-81
A sex difference has been reported in the responsiveness of the vomeronasal (VN) system to pheromones. In the present study, to clarify a direct and acute influence of 17β-estradiol (E2) on the accessory olfactory bulb (AOB) neurons, we investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71b61e7c11ac1dbb0905f56a547145d
https://doi.org/10.1016/j.neulet.2011.06.005
https://doi.org/10.1016/j.neulet.2011.06.005
Publikováno v:
Proceedings of the National Academy of Sciences. 106:3531-3536
Protein kinase A (PKA)-dependent signaling cascades play an important role in mediating the effects of dopamine and other neurotransmitters in striatal medium spiny neurons. We have identified a prominent striatal PKA substrate as Rap1-GTPase activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9925fdd36bb72b410d7de6c175a70617
https://doi.org/10.1073/pnas.0813263106
https://doi.org/10.1073/pnas.0813263106
Publikováno v:
Neuroscience. 149:457-464
The proximate cause of Parkinson's disease is striatal dopamine depletion. Although no overt toxicity to striatal neurons has been reported in Parkinson's disease, one of the consequences of striatal dopamine loss is a decrease in the number of dendr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e55aa1d76c97faf27c5f0cbf5ab9d5
https://doi.org/10.1016/j.neuroscience.2007.06.044
https://doi.org/10.1016/j.neuroscience.2007.06.044
Autor:
Kazuyoshi Murata, Yasunori Hayashi, Radhakrishnan Narayanan, Sang Hyoung Lee, Ken-ichi Okamoto
Publikováno v:
Proceedings of the National Academy of Sciences. 104:6418-6423
Ca 2+ -calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine protein kinase critically involved in synaptic plasticity in the brain. It is highly concentrated in the postsynaptic density fraction, exceeding the amount of any other sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ccb027f386796010979983dffe329c
https://doi.org/10.1073/pnas.0701656104
https://doi.org/10.1073/pnas.0701656104
Publikováno v:
The FASEB Journal. 29
Early postnatal anesthesia causes long-lasting learning and memory impairment in rodents, however, the underlying mechanisms remain largely unknown. We tested a hypothesis that clinically relevant ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b60adc20f91c3ad3344d4b3720baa578
https://doi.org/10.1096/fasebj.29.1_supplement.lb43
https://doi.org/10.1096/fasebj.29.1_supplement.lb43