Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs

Autor: Sonja I. Gringhuis, Tanja M. Kaptein, Ester B. M. Remmerswaal, Agata Drewniak, Brigitte A. Wevers, Bart Theelen, Geert R. A. M. D’Haens, Teun Boekhout, Teunis B. H. Geijtenbeek

Publikováno v: Nature Immunology, 23(12), 1735-1748. Nature Publishing Group
Nature immunology, 23(12), 1735-1748. Nature Publishing Group

The non-pathogenic TH17 subset of helper T cells clears fungal infections, whereas pathogenic TH17 cells cause inflammation and tissue damage; however, the mechanisms controlling these distinct responses remain unclear. Here we found that fungi sensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb95b9e0a1be7f25f872ff5b9849bad7
https://pure.knaw.nl/portal/en/publications/02768b71-10f2-4c54-9daa-117c4aec0199

Manifold Roles of CCR7 and Its Ligands in the Induction and Maintenance of Bronchus-Associated Lymphoid Tissue

Autor: Sanjiv A. Luther, Gerd Sutter, Reinhold Förster, Anja Bubke, Marc Permanyer, Stefanie Willenzon, Berislav Bošnjak, Henrike Fleige, Jasmin Ristenpart

Publikováno v: Cell reports, vol. 23, no. 3, pp. 783-795
Cell Reports, Vol 23, Iss 3, Pp 783-795 (2018)

Summary: The processes underlying the development and maintenance of tertiary lymphoid organs are incompletely understood. Using a Ccr7 knockout/knockin approach, we show that spontaneous bronchus-associated lymphoid tissue (BALT) formation can be ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c34892c25d581f23ba5b5724047ddf4
https://doi.org/10.1016/j.celrep.2018.03.072

Impact of Hydroxyglutarate on Dendritic Cell Activation

Autor: Cardenas-Conejo, Zugey Elizabeth

Tumor development is commonly associated with genetic alterations such as activation of oncogenes or the silencing of tumor suppressor genes. Recently point mutations in genes encoding isocitrate dehydrogenase (IDH) have gained substantial interest i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f87c3e15ad1313a5719c7567a9747ec

Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells

Autor: Nikita Subedi, Aigars Piruska, Alexander van Oudenaarden, Nicole van Buuringen, Jurjen Tel, Florian Wimmers, Daan Heister, Inge Beeren-Reinieren, Carl G. Figdor, Joannes F M Jacobs, I. Jolanda M. de Vries, Wilhelm T. S. Huck, Harry Dolstra, Judith Vivié, Rob Woestenenk

Publikováno v: Nature Communications, 9(1). Nature Publishing Group
Nature Communications, 9(1):3317. Nature Publishing Group
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications, 9, 1-12
Nature Communications, 9, pp. 1-12

Type I interferon (IFN) is a key driver of immunity to infections and cancer. Plasmacytoid dendritic cells (pDCs) are uniquely equipped to produce large quantities of type I IFN but the mechanisms that control this process are poorly understood. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bed2a5a13c25dce37737c375fc2c5c
https://doi.org/10.1038/s41467-018-05784-3

The CLEC12A receptor marks human basophils::Potential implications for minimal residual disease detection in acute myeloid leukemia

Autor: Toft-Petersen, Marie, Stidsholt Roug, Anne, Plesner, Trine, Ebbesen, Lene, Brown, Gordon D., Nederby, Line

Publikováno v: Toft-Petersen, M, Stidsholt Roug, A, Plesner, T, Ebbesen, L, Brown, G D & Nederby, L 2018, ' The CLEC12A receptor marks human basophils: Potential implications for minimal residual disease detection in acute myeloid leukemia ', Cytometry. Part B: Clinical Cytometry, vol. 94, no. 3, pp. 520-526 . https://doi.org/10.1002/cyto.b.21540
Toft-Petersen, M, Stidsholt Roug, A, Plesner, T, Ebbesen, L, Brown, G D & Nederby, L 2018, ' The CLEC12A receptor marks human basophils : Potential implications for minimal residual disease detection in acute myeloid leukemia ', Cytometry. Part B: Clinical Cytometry, vol. 94, no. 3, pp. 520-526 . https://doi.org/10.1002/cyto.b.21540

BACKGROUND: The transmembrane receptor C-type lectin domain family 12, member A (CLEC12A) is known to be highly expressed on monocytes and neutrophils and is a reliable leukemia associated marker in acute myeloid leukemia. Consequently, detailed know

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fb0f54389f461991dd2a22f1bbda6b7d
https://pure.au.dk/portal/da/publications/the-clec12a-receptor-marks-human-basophils(c501d4ba-cf84-4d4a-a386-e5773a1d8208).html