Longitudinal analysis of DC subsets in patients with ovarian cancer: Implications for immunotherapy

Autor: Mastelic-Gavillet, B., Sarivalasis, A., Lozano, L.E., Lofek, S., Wyss, T., Melero, I., de Vries, IJM, Harari, A., Romero, P., Kandalaft, L.E., Viganó, S.

Publikováno v: Frontiers in immunology, vol. 14, pp. 1119371
Frontiers in Immunology, 14

BackgroundThe use of circulating cDC1 to generate anti-cancer vaccines is among the most promising approaches to overcome the limited immunogenicity and clinical efficacy of monocyte-derived DC. However, the recurrent lymphopenia and the reduction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c7ba051339c604d73a1532843207bf
https://doi.org/10.3389/fimmu.2023.1119371

TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection

Autor: Renée M van der Sluis, Lamin B Cham, Albert Gris‐Oliver, Kristine R Gammelgaard, Jesper G Pedersen, Manja Idorn, Ulvi Ahmadov, Sabina Sanches Hernandez, Ena Cémalovic, Stine H Godsk, Jacob Thyrsted, Jesper D Gunst, Silke D Nielsen, Janni J Jørgensen, Tobias Wang Bjerg, Anders Laustsen, Line S Reinert, David Olagnier, Rasmus O Bak, Mads Kjolby, Christian K Holm, Martin Tolstrup, Søren R Paludan, Lasse S Kristensen, Ole S Søgaard, Martin R Jakobsen

Publikováno v: van der Sluis, R M, Cham, L B, Gris-Oliver, A, Gammelgaard, K R, Pedersen, J G, Idorn, M, Ahmadov, U, Sanches Hernandez, S, Cémalovic, E, Godsk, S H, Thyrsted, J, Gunst, J D, Nielsen, S D, Jørgensen, J J, Wang Bjerg, T, Laustsen, A, Reinert, L S, Olagnier, D, Bak, R O, Kjolby, M, Holm, C K, Tolstrup, M, Paludan, S R, Kristensen, L S, Søgaard, O S & Jakobsen, M R 2022, ' TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection ', The EMBO Journal, pp. e109622 . https://doi.org/10.15252/embj.2021109622
van der Sluis, R M, Cham, L B, Gris-Oliver, A, Gammelgaard, K R, Pedersen, J G, Idorn, M, Ahmadov, U, Hernandez, S S, Cémalovic, E, Godsk, S H, Thyrsted, J, Gunst, J D, Nielsen, S D, Jørgensen, J J, Bjerg, T W, Laustsen, A, Reinert, L S, Olagnier, D, Bak, R O, Kjolby, M, Holm, C K, Tolstrup, M, Paludan, S R, Kristensen, L S, Søgaard, O S & Jakobsen, M R 2022, ' TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection ', EMBO Journal, vol. 41, no. 10, e109622 . https://doi.org/10.15252/embj.2021109622

Understanding the molecular pathways driving the acute antiviral and inflammatory response to SARS-CoV-2 infection is critical for developing treatments for severe COVID-19. Here, we find decreasing number of circulating plasmacytoid dendritic cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1fd30736af2a491a85fdee063fc4b93
https://doi.org/10.15252/embj.2021109622

SARS-CoV-2–associated ssRNAs activate inflammation and immunity via TLR7/8

Autor: Francesca Sozio, Ilaria Barbazza, Daniela Bosisio, Cecilia Garlanda, Alberto Mantovani, Annalisa Del Prete, Mauro Passari, Laura Tiberio, Tiziana Schioppa, Hoang Oanh Nguyen, Mattia Laffranchi, Patrizia Scapini, Marco A. Cassatella, Silvano Sozzani, Nicola Tamassia, Valentina Salvi

Publikováno v: Università degli Studi di Brescia-IRIS
JCI Insight

The inflammatory and IFN pathways of innate immunity play a key role in both resistance and pathogenesis of Coronavirus Disease 2019 (COVID-19). Innate sensors and SARS-CoV-2-Associated Molecular Patterns (SAMPs) remain to be completely defined. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ccec6100c16c901a3fa9c7aaba1843
https://doi.org/10.1172/jci.insight.150542

Identification and tissue-expression profiling of novel chicken c-type lectin-like domain containing proteins as potential targets for carbohydrate-based vaccine strategies

Autor: Bernt Guldbrandtsen, Bertrand Bed'Hom, Frederik T. Larsen, Tina S. Dalgaard

Publikováno v: Molecular Immunology
Molecular Immunology, Elsevier, 2019, 114, pp.216-225. ⟨10.1016/j.molimm.2019.07.022⟩
Larsen, F T, Bed'hom, B, Guldbrandtsen, B & Dalgaard, T S 2019, ' Identification and tissue-expression profiling of novel chicken c-type lectin-like domain containing proteins as potential targets for carbohydrate-based vaccine strategies ', Molecular Immunology, vol. 114, no. October, pp. 216-225 . https://doi.org/10.1016/j.molimm.2019.07.022

International audience; C-type lectin-like domain containing proteins (CTLDcps) mainly bind carbohydrate-based ligands, but also other ligands. CTLDcps are involved in several biological processes including cell adhesion, cell-cell interactions, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81adeb755e4085035a96faab551771e
https://doi.org/10.1016/j.molimm.2019.07.022

Gene activation precedes DNA demethylation in response to infection in human dendritic cells

Autor: Anne Dumaine, Luis B. Barreiro, Ludovic Tailleux, Florence Mailhot-Léonard, Haley E. Randolph, Alain Pacis, Jean-Christophe Grenier, Vania Yotova

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (14), pp.6938-6943. ⟨10.1073/pnas.1814700116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (14), pp.6938-6943. ⟨10.1073/pnas.1814700116⟩

Significance Immune response to infection is accompanied by active demethylation of thousands of CpG sites. Yet, the causal relationship between changes in DNA methylation and gene expression during infection remains to be elucidated. Here, we invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d1ec2f5b67bee7e15b2a518a09f484
http://europepmc.org/articles/PMC6452747