IL-10 Dampens TNF/Inducible Nitric Oxide Synthase-Producing Dendritic Cell-Mediated Pathogenicity during Parasitic Infection

Autor: Alain Beschin, Muriel Moser, Patrick De Baetselier, Tom Bosschaerts, Martin Guilliams, Marinee Khim Chuah, Michel Hérin, Thierry VandenDriessche, Abel Acosta-Sanchez, Lea Brys, Jo A. Van Ginderachter, Ling Ma, Kiavash Movahedi

Publikováno v: Vrije Universiteit Brussel

Antiparasite responses are associated with the recruitment of monocytes that differentiate to macrophages and dendritic cells at the site of infection. Although classically activated monocytic cells are assumed to be the major source of TNF and NO du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ee51bc88932031d8fcaa8c91b177a8
https://doi.org/10.4049/jimmunol.182.2.1107

CX(3)CR1(+) CD115(+) CD135(+) common macrophage/DC precursors and the role of CX(3)CR1 in their response to inflammation

Autor: Cédric Auffray, Ana Cumano, Grégoire Lauvau, Laura Campisi, Frederic Geissmann, Darin K. Fogg, Thierry Jo Molina, David A. Hume, Céline Trouillet, Brigitte Senechal, Julia Leemput, Karine Bigot, Emilie Narni-Mancinelli, Marc Abitbol, Noah Saederup, Israel F. Charo

Publikováno v: Auffray, C, Fogg, D K, Narni-Mancinelli, E, Senechal, B, Trouillet, C, Saederup, N, Leemput, J, Bigot, K, Campisi, L, Abitbol, M, Molina, T, Charo, I, Hume, D A, Cumano, A, Lauvau, G & Geissmann, F 2009, ' CX(3)CR1(+) CD115(+) CD135(+) common macrophage/DC precursors and the role of CX(3)CR1 in their response to inflammation ', Journal of Experimental Medicine, vol. 206, no. 3, pp. 595-606 . https://doi.org/10.1084/jem.20081385
Journal of Experimental Medicine
Journal of Experimental Medicine, 2009, 206 (3), pp.595-606. ⟨10.1084/jem.20081385⟩
The Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2009, 206 (3), pp.595-606. ⟨10.1084/jem.20081385⟩
The Journal of Experimental Medecine
The Journal of Experimental Medecine, The Rockefeller University Press, 2009, 206 (3), pp.595-606. 〈10.1084/jem.20081385〉

International audience; CX(3)CR1 expression is associated with the commitment of CSF-1R(+) myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R(+) CX(3)CR1(+) macrophage/DC precursor (MDP) with oth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f67d62a1cd1a75779217f556259f301
https://www.pure.ed.ac.uk/ws/files/12572592/J_Exp_Med_2009_Auffray_pdf.pdf

iNOS-Producing Inflammatory Dendritic Cells Constitute the Major Infected Cell Type during the Chronic Leishmania major Infection Phase of C57BL/6 Resistant Mice

Autor: Shizuo Akira, Yves Carlier, Carl De Trez, Bernhard Ryffel, Eric Muraille, Stefan Magez

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2009, 5 (6), pp.e1000494. ⟨10.1371/journal.ppat.1000494⟩
P L o S Pathogens, 5 (6
Vrije Universiteit Brussel
PLoS Pathogens, Vol 5, Iss 6, p e1000494 (2009)

Leishmania major parasites reside and multiply in late endosomal compartments of host phagocytic cells. Immune control of Leishmania growth absolutely requires expression of inducible Nitric Oxide Synthase (iNOS/NOS2) and subsequent production of NO.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3573a64c4d8a213a7523d5fc63dcbab7
https://doi.org/10.1371/journal.ppat.1000494