Combined KRAS-MAPK pathway inhibitors and HER2-directed drug conjugate is efficacious in pancreatic cancer

Autor: Ashenafi Bulle, Peng Liu, Kuljeet Seehra, Sapana Bansod, Yali Chen, Kiran Zahra, Vikas Somani, Iftikhar Ali Khawar, Hung-Po Chen, Paarth B. Dodhiawala, Lin Li, Yutong Geng, Chia-Kuei Mo, Jay Mahsl, Li Ding, Ramaswamy Govindan, Sherri Davies, Jacqueline Mudd, William G. Hawkins, Ryan C. Fields, David G. DeNardo, Deborah Knoerzer, Jason M. Held, Patrick M. Grierson, Andrea Wang-Gillam, Marianna B. Ruzinova, Kian-Huat Lim

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract Targeting the mitogen-activated protein kinase (MAPK) cascade in pancreatic ductal adenocarcinoma (PDAC) remains clinically unsuccessful. We aim to develop a MAPK inhibitor-based therapeutic combination with strong preclinical efficacy. Util

Externí odkaz: https://doaj.org/article/fb6737dcacf54c9e884795a4aec86099

Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimens

Autor: Scott J. Denardo, Pavlos P. Vlachos, Brett A. Meyers, Reza Babakhani-Galangashi, Lin Wang, Zejin Gao, James E. Tcheng

Publikováno v: Platelets, Vol 35, Iss 1 (2024)

AbstractPlatelets are central to thrombosis. Research at the intersection of biological and physical sciences provides proof-of-concept for shear rate-dependent platelet slip at vascular stenosis and near device surfaces. Platelet slip extends the ob

Externí odkaz: https://doaj.org/article/1e2368798ccb4e3e9ca86a32e1635a19

Effects of thermophily-relevant temperature variation and sex on digestive performance in pythons

Autor: Benson, Derek M., DeNardo, Dale F.

Publikováno v: In Comparative Biochemistry and Physiology, Part A July 2024 293

#46. cAMP-mediated acid signaling regulates tumor-myeloid-bone cell crosstalk in the bone-tumor microenvironment

Autor: Kaylee O'Donnell, Xinming Su, Yalin Xu, Kristin A. Kwakwa, Deborah J. Veis, David G. DeNardo, Gregory M. Lanza, Katherine N. Weilbaecher

Publikováno v: Journal of Bone Oncology, Vol 45, Iss , Pp 100584- (2024)

Externí odkaz: https://doaj.org/article/48311769d8454d7e80f97333d62930cc

Measurement of the Masses and Widths of the $\Sigma_c(2455)^+$ and $\Sigma_c(2520)^+$ Baryons

Autor: Belle Collaboration, Yelton, J., Adachi, I., Ahn, J. K., Aihara, H., AlSaid, S., Asner, D. M., Atmacan, H., Aulchenko, V., Aushev, T., Ayad, R., Babu, V., Bahinipati, S., Behera, P., Belous, K., Bennett, J., Bessner, M., Bhardwaj, V., Bhuyan, B., Bilka, T., Biswal, J., Bozek, A., Bracko, M., Branchini, P., Browder, T. E., Budano, A., Campajola, M., Cervenkov, D., Chang, M. -C., Chang, P., Chekelian, V., Chen, A., Cheon, B. G., Chilikin, K., Cho, H. E., Cho, K., Cho, S. -J., Choi, S. -K., Choi, Y., Choudhury, S., Cinabro, D., Cunliffe, S., Das, S., Dash, N., DeNardo, G., DePietro, G., Dhamija, R., DiCapua, F., Dingfelder, J., Dolezal, Z., Dong, T. V., Epifanov, D., Ferber, T., Ferlewicz, D., Fulsom, B. G., Garg, R., Gaur, V., Gabyshev, N., Garmash, A., Giri, A., Goldenzweig, P., Graziani, E., Gu, T., Gudkova, K., Hadjivasiliou, C., Hara, T., Hartbrich, O., Hayasaka, K., Hayashii, H., Hou, W. -S., Hsu, C. -L., Inami, K., Ishikawa, A., Itoh, R., Iwasaki, M., Iwasaki, Y., Jacobs, W. W., Jia, S., Jin, Y., Joo, K. K., Kaliyar, A. B., Kang, K. H., Kato, Y., Kiesling, C., Kim, C. H., Kim, D. Y., Kim, K. -H., Kim, S. H., Kim, Y. -K., Kinoshita, K., Kodys, P., Konno, T., Korobov, A., Korpar, S., Kovalenko, E., Krizan, P., Kroeger, R., Krokovny, P., Kuhr, T., Kulasiri, R., Kumara, K., Kwon, Y. -J., Lange, J. S., Laurenza, M., Lee, S. C., Li, J., Li, L. K., Li, Y. B., LiGioi, L., Libby, J., Lieret, K., Liventsev, D., MacQueen, C., Masuda, M., Matsuda, T., Matvienko, D., McNeil, J. T., Merola, M., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Moon, T. J., Mussa, R., Nakao, M., Natkaniec, Z., Natochii, A., Nayak, L., Nayak, M., Niiyama, M., Nisar, N. K., Nishida, S., Ogawa, S., Ono, H., Onuki, Y., Oskin, P., Pakhlov, P., Pakhlova, G., Pardi, S., Park, H., Park, S. -H., Paul, S., Pedlar, T. K., Pestotnik, R., Piilonen, L. E., Podobnik, T., Prencipe, E., Prim, M. T., Rostomyan, A., Rout, N., Russo, G., Sahoo, D., Sakai, Y., Sandilya, S., Sangal, A., Santelj, L., Sanuki, T., Savinov, V., Schnell, G., Schueler, J., Schwanda, C., Seino, Y., Senyo, K., Sevior, M. E., Shapkin, M., Sharma, C., Shen, C. P., Shiu, J. -G., Sokolov, A., Solovieva, E., Staric, M., Stottler, Z. S., Sumihama, M., Sumisawa, K., Sumiyoshi, T., Takizawa, M., Tamponi, U., Tanida, K., Tao, Y., Tenchini, F., Trabelsi, K., Uchida, M., Uglov, T., Unno, Y., Uno, S., Urquijo, P., Usov, Y., Vahsen, S. E., VanTonder, R., Varner, G., Vinokurova, A., Waheed, E., Wang, C. H., Wang, D., Wang, E., Wang, M. -Z., Wang, P., Watanabe, M., Watanuki, S., Won, E., Yabsley, B. D., Yan, W., Yang, S. B., Ye, H., Yin, J. H., Yuan, C. Z., Zhang, Z. P., Zhilich, V., Zhukova, V.

Publikováno v: Phys. Rev. D 104, 052003 (2021)

Using 980 ${\rm fb}^{-1}$ of data {collected} with the Belle detector operating at the KEKB asymmetric-energy $e^+e^-$ collider, we report the measurements of the masses, and the first measurements of the instrinsic widths, of the $\Sigma_c(2455)^+$

Externí odkaz: http://arxiv.org/abs/2107.05615