Homeostatic PD-1 signaling restrains EOMES-dependent oligoclonal expansion of liver-resident CD8 T cells.

Autor: Le Moine M; Institute for Medical Immunology (IMI), Université Libre de Bruxelles (ULB), Gosselies, Belgium; ULB Center for Research in Immunology (U-CRI), ULB, Brussels, Belgium., Azouz A; Institute for Medical Immunology (IMI), Université Libre de Bruxelles (ULB), Gosselies, Belgium; ULB Center for Research in Immunology (U-CRI), ULB, Brussels, Belgium., Sanchez Sanchez G; Institute for Medical Immunology (IMI), Université Libre de Bruxelles (ULB), Gosselies, Belgium; ULB Center for Research in Immunology (U-CRI), ULB, Brussels, Belgium; Department of Pharmacotherapy and Pharmaceutics, ULB, Brussels, Belgium., Dejolier S; ULB Center for Research in Immunology (U-CRI), ULB, Brussels, Belgium; Immunobiology Lab, ULB, Gosselies, Belgium., Nguyen M; Institute for Medical Immunology (IMI), Université Libre de Bruxelles (ULB), Gosselies, Belgium; ULB Center for Research in Immunology (U-CRI), ULB, Brussels, Belgium., Thomas S; Institute for Medical Immunology (IMI), Université Libre de Bruxelles (ULB), Gosselies, Belgium; ULB Center for Research in Immunology (U-CRI), ULB, Brussels, Belgium., Shala V; Institute for Medical Immunology (IMI), Université Libre de Bruxelles (ULB), Gosselies, Belgium; ULB Center for Research in Immunology (U-CRI), ULB, Brussels, Belgium., Dreidi H; ULB Center for Research in Immunology (U-CRI), ULB, Brussels, Belgium; Immunobiology Lab, ULB, Gosselies, Belgium., Denanglaire S; ULB Center for Research in Immunology (U-CRI), ULB, Brussels, Belgium; Immunobiology Lab, ULB, Gosselies, Belgium., Libert F; Institute of Interdisciplinary Research (IRIBHM) and Brightcore, ULB, Brussels, Belgium., Vermijlen D; Institute for Medical Immunology (IMI), Université Libre de Bruxelles (ULB), Gosselies, Belgium; ULB Center for Research in Immunology (U-CRI), ULB, Brussels, Belgium; Department of Pharmacotherapy and Pharmaceutics, ULB, Brussels, Belgium; WELBIO Department, WEL Research Institute, Avenue Pasteur, 6, 1300 Wavre, Belgium., Andris F; ULB Center for Research in Immunology (U-CRI), ULB, Brussels, Belgium; Immunobiology Lab, ULB, Gosselies, Belgium., Goriely S; Institute for Medical Immunology (IMI), Université Libre de Bruxelles (ULB), Gosselies, Belgium; ULB Center for Research in Immunology (U-CRI), ULB, Brussels, Belgium; Immunobiology Lab, ULB, Gosselies, Belgium. Electronic address: stanislas.goriely@ulb.be.

Publikováno v: Cell reports [Cell Rep] 2023 Aug 29; Vol. 42 (8), pp. 112876. Date of Electronic Publication: 2023 Aug 04.

The oxygen sensor prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells.

Autor: Ajouaou Y; U-CRI (ULB Center for Research in Immunology), Université Libre de Bruxelles (ULB), Charleroi, Belgium.; Immunobiology Laboratory, Université Libre de Bruxelles (ULB), Charleroi, Belgium., Azouz A; U-CRI (ULB Center for Research in Immunology), Université Libre de Bruxelles (ULB), Charleroi, Belgium.; Institute for Medical Immunology, Université Libre de Bruxelles (ULB), Charleroi, Belgium., Taquin A; U-CRI (ULB Center for Research in Immunology), Université Libre de Bruxelles (ULB), Charleroi, Belgium.; Immunobiology Laboratory, Université Libre de Bruxelles (ULB), Charleroi, Belgium., Denanglaire S; U-CRI (ULB Center for Research in Immunology), Université Libre de Bruxelles (ULB), Charleroi, Belgium.; Immunobiology Laboratory, Université Libre de Bruxelles (ULB), Charleroi, Belgium., Hussein H; U-CRI (ULB Center for Research in Immunology), Université Libre de Bruxelles (ULB), Charleroi, Belgium.; Immunobiology Laboratory, Université Libre de Bruxelles (ULB), Charleroi, Belgium., Krayem M; Department of Radiation Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.; Laboratory of Clinical and Experimental Oncology (LOCE), Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium., Andris F; U-CRI (ULB Center for Research in Immunology), Université Libre de Bruxelles (ULB), Charleroi, Belgium.; Immunobiology Laboratory, Université Libre de Bruxelles (ULB), Charleroi, Belgium., Moser M; U-CRI (ULB Center for Research in Immunology), Université Libre de Bruxelles (ULB), Charleroi, Belgium.; Immunobiology Laboratory, Université Libre de Bruxelles (ULB), Charleroi, Belgium., Goriely S; U-CRI (ULB Center for Research in Immunology), Université Libre de Bruxelles (ULB), Charleroi, Belgium.; Immunobiology Laboratory, Université Libre de Bruxelles (ULB), Charleroi, Belgium.; Institute for Medical Immunology, Université Libre de Bruxelles (ULB), Charleroi, Belgium., Leo O; U-CRI (ULB Center for Research in Immunology), Université Libre de Bruxelles (ULB), Charleroi, Belgium.; Immunobiology Laboratory, Université Libre de Bruxelles (ULB), Charleroi, Belgium.

Publikováno v: ELife [Elife] 2022 Feb 22; Vol. 11. Date of Electronic Publication: 2022 Feb 22.

Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of reactive oxygen species.

Autor: Lepez A; ULB Centre for Research in Immunology (U-CRI), Université Libre de Bruxelles, Brussels, Belgium.; Laboratory of Immunobiology, Université Libre de Bruxelles - IBMM, 12, rue des Prof. Jeener et Brachet, 6041, Brussels, Belgium., Pirnay T; ULB Centre for Research in Immunology (U-CRI), Université Libre de Bruxelles, Brussels, Belgium.; Laboratory of Immunobiology, Université Libre de Bruxelles - IBMM, 12, rue des Prof. Jeener et Brachet, 6041, Brussels, Belgium., Denanglaire S; ULB Centre for Research in Immunology (U-CRI), Université Libre de Bruxelles, Brussels, Belgium.; Laboratory of Immunobiology, Université Libre de Bruxelles - IBMM, 12, rue des Prof. Jeener et Brachet, 6041, Brussels, Belgium., Perez-Morga D; Centre for Microscopy and Molecular Imaging (CMMI), Université Libre de Bruxelles, Brussels, Belgium.; Laboratory of Molecular Parasitology, Université Libre de Bruxelles, Brussels, Belgium., Vermeersch M; Centre for Microscopy and Molecular Imaging (CMMI), Université Libre de Bruxelles, Brussels, Belgium., Leo O; ULB Centre for Research in Immunology (U-CRI), Université Libre de Bruxelles, Brussels, Belgium.; Laboratory of Immunobiology, Université Libre de Bruxelles - IBMM, 12, rue des Prof. Jeener et Brachet, 6041, Brussels, Belgium., Andris F; ULB Centre for Research in Immunology (U-CRI), Université Libre de Bruxelles, Brussels, Belgium. Fabienne.Andirs@ulb.be.; Laboratory of Immunobiology, Université Libre de Bruxelles - IBMM, 12, rue des Prof. Jeener et Brachet, 6041, Brussels, Belgium. Fabienne.Andirs@ulb.be.

Publikováno v: Scientific reports [Sci Rep] 2020 Dec 10; Vol. 10 (1), pp. 21673. Date of Electronic Publication: 2020 Dec 10.

Multiple Environmental Signaling Pathways Control the Differentiation of RORγt-Expressing Regulatory T Cells.

Autor: Hussein H; Laboratoire d'Immunobiologie, Université Libre de Bruxelles, Brussels, Belgium., Denanglaire S; Laboratoire d'Immunobiologie, Université Libre de Bruxelles, Brussels, Belgium., Van Gool F; Diabetes Center, University of California, San Francisco, San Francisco, CA, United States.; Sean N. Parker Autoimmune Research Laboratory, University of California, San Francisco, San Francisco, CA, United States., Azouz A; Institute for Medical Immunology (IMI), Université Libre de Bruxelles, Gosselies, Belgium., Ajouaou Y; Laboratoire d'Immunobiologie, Université Libre de Bruxelles, Brussels, Belgium., El-Khatib H; Laboratoire d'Immunobiologie, Université Libre de Bruxelles, Brussels, Belgium., Oldenhove G; Laboratoire d'Immunobiologie, Université Libre de Bruxelles, Brussels, Belgium., Leo O; Laboratoire d'Immunobiologie, Université Libre de Bruxelles, Brussels, Belgium., Andris F; Laboratoire d'Immunobiologie, Université Libre de Bruxelles, Brussels, Belgium.

Publikováno v: Frontiers in immunology [Front Immunol] 2020 Jan 08; Vol. 10, pp. 3007. Date of Electronic Publication: 2020 Jan 08 (Print Publication: 2019).

Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8 ⁺ T cells.

Autor: Hanoteau A; Department of Molecular Biology, ULB Cancer Research Center, Université Libre de Bruxelles, Gosselies, Belgium., Henin C; Department of Molecular Biology, ULB Cancer Research Center, Université Libre de Bruxelles, Gosselies, Belgium., Svec D; Institute of Biotechnology, Academy of Science of the Czech Republic, Prague, Czech Republic., Bisilliat Donnet C; Department of Molecular Biology, ULB Cancer Research Center, Université Libre de Bruxelles, Gosselies, Belgium., Denanglaire S; Department of Molecular Biology, ULB Cancer Research Center, Université Libre de Bruxelles, Gosselies, Belgium., Colau D; Ludwig Institute for Cancer Research of the Université Catholique de Louvain, Brussels, Belgium., Romero P; Ludwig Institute for Cancer Research of the University of Lausanne, Epalinges, Switzerland., Leo O; Department of Molecular Biology, ULB Cancer Research Center, Université Libre de Bruxelles, Gosselies, Belgium., Van den Eynde B; Ludwig Institute for Cancer Research of the Université Catholique de Louvain, Brussels, Belgium., Moser M; Department of Molecular Biology, ULB Cancer Research Center, Université Libre de Bruxelles, Gosselies, Belgium.

Publikováno v: Oncoimmunology [Oncoimmunology] 2017 May 11; Vol. 6 (8), pp. e1318234. Date of Electronic Publication: 2017 May 11 (Print Publication: 2017).