Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Dena Toffaletti"'
Autor:
Kristie Goughenour, Arianna Creech, Jintao Xu, Xiumiao He, Rylan Hissong, Charles Giamberardino, Jennifer Tenor, Dena Toffaletti, John Perfect, Michal Olszewski
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Trehalose-6-phosphate synthase (TPS1) was identified as a virulence factor for Cryptococcus neoformans and a promising therapeutic target. This study reveals previously unknown roles of TPS1 in evasion of host defenses during pulmonary and disseminat
Externí odkaz:
https://doaj.org/article/ac446f0785654232965c71267fca7b96
Autor:
Charles D Giamberardino, Jennifer L Tenor, Dena Toffaletti, Julia R Palmucci, Don Cilla, William Hope, John R Perfect
Publikováno v:
Open Forum Infectious Diseases. 9
Background Cryptococcal meningitis (CM) is a fungal disease with significant global morbidity and mortality. There are multiple new therapies being developed to improve the current regimens involving amphotericin B, flucytosine, and fluconazole. ATI-
Autor:
Julia A Messina, Charles D Giamberardino, Jennifer Tenor, Dena Toffaletti, Wiley Schell, Michail Lionakis, John R Perfect
Publikováno v:
Open Forum Infectious Diseases. 8:S458-S458
Background Patients receiving the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib have an increased likelihood of systemic and central nervous system (CNS) fungal infections. Previous work has shown that BTK knockout (KO) mice have more severe A