Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Dena Digweed"'
Autor:
Heiko Krude, Uta Neumann, John Porter, Bernard Voet, Martin J. Whitaker, Katarina Braune, Oliver Blankenstein, Dena Digweed, Richard J. Ross, Susanna Wiegand
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Context Children with congenital adrenal hyperplasia (CAH) and adrenal insufficiency (AI) require daily hydrocortisone replacement with accurate dosing. Objective Prospective study of efficacy and safety of hydrocortisone granules in children with AI
Autor:
Nikolaos Nikolaou, Martin J. Whitaker, Sherly George, Laura Gathercole, Jeremy W. Tomlinson, Nathan Appanna, Anastasia Arvaniti, Brian G. Keevil, Richard J. Ross, Leanne Hodson, Trevor M. Penning, Dena Digweed, Anna Sharp, Wiebke Arlt, Karen Morris, Beverly A. Hughes
Publikováno v:
The Journal of Endocrinology
Steroid 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates endogenous glucocorticoids and catalyses an important step in bile acid synthesis. Endogenous and synthetic glucocorticoids are potent regulators of metabolic phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca250f9a3465febe7476f13cfae4f50
http://hdl.handle.net/10044/1/101689
http://hdl.handle.net/10044/1/101689
Autor:
Susanna Wiegand, Bernard Voet, Uta Neumann, Oliver Blankenstein, Richard J. Ross, Dena Digweed, John Porter, Martin J. Whitaker, Heiko Krude, Madhu Davies
Publikováno v:
Endocrine Abstracts.
Objectives There is no licensed, dose-appropriate formulation of hydrocortisone for children with adrenal insufficiency (AI) and patients rely on compounded adult medication. The aim of this study was to evaluate the absorption, palatability and safe
Publikováno v:
Journal of the Endocrine Society
Background Immediate-release hydrocortisone granules in capsules for opening in pediatric-appropriate doses have recently been licensed for children with adrenal insufficiency. This study evaluated the bioavailability of hydrocortisone granules admin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa12ecd794c9737d4f9b0783ba73dda
https://eprints.whiterose.ac.uk/144666/3/js.2018-00380.pdf
https://eprints.whiterose.ac.uk/144666/3/js.2018-00380.pdf
Autor:
Martin J. Whitaker, Anna Sharp, Nikolaos Nikolaou, Jeremy Tomlinson, Gareth Lavery, Wiebke Arlt, Laura Gathercole, Stuart A. Morgan, Zachariah Raouf, Beverly A. Hughes, Dean Larner, Dena Digweed, Richard S. Ross
Publikováno v:
Endocrine Abstracts.
Autor:
Ashwini Mallappa, Deborah P. Merke, Martin J. Whitaker, Parag Kumar, Lori Ann Daley, David Eckland, Lynnette K. Nieman, Dena Digweed, Wiebke Arlt, Richard J. Ross, Ninet Sinaii, Carol Van Ryzin
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:1137-1145
Treatment of congenital adrenal hyperplasia (CAH) is suboptimal. Inadequate suppression of androgens and glucocorticoid excess are common and current glucocorticoid formulations cannot replace the cortisol circadian rhythm.The primary objective was t
Autor:
Richard S. Ross, Dena Digweed, Brian G. Keevil, Wiebke Arlt, Miguel Debono, Robert F. Harrison, Martin J. Whitaker
Publikováno v:
Endocrine Abstracts.
Autor:
Martin J. Whitaker, Hiep Huatan, Trevor N. Johnson, Heiko Krude, Geoffrey T. Tucker, Oliver Blankenstein, Richard J. Ross, David Eckland, Dena Digweed, Sarah Spielmann
Publikováno v:
The Journal of clinical endocrinology and metabolism. 100(4)
Treatment of neonates and infants with adrenal insufficiency is unsatisfactory because unlicensed hydrocortisone formulations are used.The objectives were to survey current hydrocortisone prescribing practice and develop a novel hydrocortisone formul
Autor:
Heiko Krude, Oliver Blankenstein, Dena Digweed, Sarah Spielmann, David Eckland, Richard S. Ross, Martin J. Whitaker, Hiep Huatan
Publikováno v:
Endocrine Abstracts.
Current treatment in Europe for adrenal insufficiency in neonates and infants is unsatisfactory as unlicensed adult dosage formulations are used. These are difficult to administer and may give rise to inconsistencies in dose as the content uniformity
Autor:
Neumann, Uta, Braune, Katarina, Whitaker, Martin J., Wiegand, Susanna, Krude, Heiko, Porter, John, Digweed, Dena, Voet, Bernard, Ross, Richard J. M., Blankenstein, Oliver
Publikováno v:
Journal of Clinical Endocrinology & Metabolism; Mar2021, Vol. 106 Issue 3, pe1433-e1440, 8p