AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease

Autor: Nikolaou, Nikolaos, Gathercole, Laura L., Marchand, Lea, Althari, Sara, Dempster, Niall J., Green, Charlotte J., van de Bunt, Martijn, McNeil, Catriona, Arvaniti, Anastasia, Hughes, Beverly A., Sgromo, Bruno, Gillies, Richard S., Marschall, Hanns-Ulrich, Penning, Trevor M., Ryan, John, Arlt, Wiebke, Hodson, Leanne, Tomlinson, Jeremy W.

Publikováno v: In Metabolism October 2019 99:67-80

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Profiling the genome and proteome of metabolic dysfunction-associated steatotic liver disease identifies potential therapeutic targets.

Autor: Liu J; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Genetics Centre-of-Excellence, Novo Nordisk Research Centre Oxford, Oxford, UK., Hu S; Genetics Centre-of-Excellence, Novo Nordisk Research Centre Oxford, Oxford, UK., Chen L; Genetics Centre-of-Excellence, Novo Nordisk Research Centre Oxford, Oxford, UK., Daly C; Department of Discovery Technology and Genomics, Novo Nordisk Research Centre Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK., Prada Medina CA; AI & Digital Research, Research & Early Development, Novo Nordisk Research Centre Oxford, UK., Richardson TG; Genetics Centre-of-Excellence, Novo Nordisk Research Centre Oxford, Oxford, UK.; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Traylor M; Genetics Centre-of-Excellence, Novo Nordisk Research Centre Oxford, Oxford, UK., Dempster NJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK., Mbasu R; Department of Discovery Technology and Genomics, Novo Nordisk Research Centre Oxford, Oxford, UK., Monfeuga T; AI & Digital Research, Research & Early Development, Novo Nordisk Research Centre Oxford, UK., Vujkovic M; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tsao PS; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Cardiovascular Medicine, School of Medicine, Stanford University, Stanford, CA, USA., Lynch JA; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, Utah, USA.; Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, USA., Voight BF; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Chang KM; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Million VA; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Genetics Centre-of-Excellence, Novo Nordisk Research Centre Oxford, Oxford, UK.; Department of Discovery Technology and Genomics, Novo Nordisk Research Centre Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.; AI & Digital Research, Research & Early Development, Novo Nordisk Research Centre Oxford, UK.; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Cardiovascular Medicine, School of Medicine, Stanford University, Stanford, CA, USA.; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, Utah, USA.; Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust and the University of Oxford, Oxford, UK.; Translational Gastroenterology Unit, University of Oxford, Oxford, UK., Cobbold JF; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust and the University of Oxford, Oxford, UK.; Translational Gastroenterology Unit, University of Oxford, Oxford, UK., Tomlinson JW; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust and the University of Oxford, Oxford, UK., van Duijn CM; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Howson JMM; Genetics Centre-of-Excellence, Novo Nordisk Research Centre Oxford, Oxford, UK.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Nov 30. Date of Electronic Publication: 2023 Nov 30.