Exposure to Gulf war illness-related chemicals exacerbates alcohol-induced liver damage in rodents.

Autor: Petrescu AD; Division of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA.; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Venter J; Division of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA.; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Danilenko DD; Division of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA., Medina D; Department of Health and Societies, University of Pennsylvania, Philadelphia, PA, 19104, USA., Grant S; Division of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA.; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., An SY; Division of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA.; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Williams E; Division of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA.; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Mireles P; Division of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA., Rhodes K; Division of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA., Tjahja M; Department of Internal Medicine, Baylor Scott & White Health, Temple, TX, 76502, USA., DeMorrow S; Division of Pharmacology and Toxicology, College of Pharmacy, Dell Medical School, The University of Texas at Austin, 1601 Trinity St Bldg. B, Austin, TX, 78701, USA. sharon.demorrow@austin.utexas.edu.; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, USA. sharon.demorrow@austin.utexas.edu.

Publikováno v: Scientific reports [Sci Rep] 2024 Jul 01; Vol. 14 (1), pp. 14981. Date of Electronic Publication: 2024 Jul 01.

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DAGLβ is the principal synthesizing enzyme of 2-AG and promotes aggressive phenotype of intrahepatic cholangiocarcinoma via AP-1/DAGLβ/miR4516 feedforward circuitry.

Autor: Ma M; Department of Pancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.; Center of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China., Zeng G; Department of Pancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.; Center of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.; Department of Gastrointestinal Surgery, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, People's Republic of China., Tan B; Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, People's Republic of China., Zhao G; Laboratory Animal Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China., Su Q; Laboratory Animal Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China., Zhang W; Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China., Song Y; Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China., Liang J; Department of Pancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.; Center of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China., Xu B; Department of Pancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.; Center of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China., Wang Z; Department of Pancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.; Center of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China., Chen J; Department of Pancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.; Center of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China., Hou M; Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, People's Republic of China., Yang C; Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Key Laboratory of Protein Modification and Degradation, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, People's Republic of China., Yun J; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China., Huang Y; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China., Lin Y; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China., Chen D; Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China., Han Y; School of Biological Sciences, University of Northern Colorado, Greeley, Colorado, United States., DeMorrow S; Research Division, Central Texas Veterans Health Care System, Temple, Texas, United States.; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas, United States.; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, Texas, United States., Liang L; Department of Pancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.; Center of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China., Lai J; Department of Pancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.; Center of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China., Huang L; Department of Pancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.; Center of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2023 Sep 01; Vol. 325 (3), pp. G213-G229. Date of Electronic Publication: 2023 Jun 27.

Ghrelin reverses ductular reaction and hepatic fibrosis in a rodent model of cholestasis.

Autor: Petrescu AD; Central Texas Veterans Health Care System, Temple, TX, 76504, USA.; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712, USA., Grant S; Central Texas Veterans Health Care System, Temple, TX, 76504, USA.; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712, USA., Williams E; Central Texas Veterans Health Care System, Temple, TX, 76504, USA.; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712, USA., Frampton G; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, 78701, USA., Reinhart EH; Department of Internal Medicine, Baylor Scott & White Health, Temple, TX, 76502, USA., Nguyen A; University of Mary Hardin-Baylor, Belton, TX, 76513, USA., An S; Central Texas Veterans Health Care System, Temple, TX, 76504, USA.; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712, USA., McMillin M; Central Texas Veterans Health Care System, Temple, TX, 76504, USA.; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, 78701, USA., DeMorrow S; Central Texas Veterans Health Care System, Temple, TX, 76504, USA. sharon.demorrow@austin.utexas.edu.; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712, USA. sharon.demorrow@austin.utexas.edu.; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, 78701, USA. sharon.demorrow@austin.utexas.edu.

Publikováno v: Scientific reports [Sci Rep] 2020 Sep 29; Vol. 10 (1), pp. 16024. Date of Electronic Publication: 2020 Sep 29.

Leptin Enhances Hepatic Fibrosis and Inflammation in a Mouse Model of Cholestasis.

Autor: Petrescu AD; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, Texas., Grant S; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, Texas., Williams E; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, Texas., An SY; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, Texas., Seth N; Department of Internal Medicine, Baylor Scott & White Health, Temple, Texas., Shell M; Department of Internal Medicine, Baylor Scott & White Health, Temple, Texas., Amundsen T; Department of Internal Medicine, Baylor Scott & White Health, Temple, Texas., Tan C; Department of Internal Medicine, Baylor Scott & White Health, Temple, Texas., Nadeem Y; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas., Tjahja M; Department of Internal Medicine, Baylor Scott & White Health, Temple, Texas., Weld L; Department of Internal Medicine, Baylor Scott & White Health, Temple, Texas., Chu CS; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, Texas., Venter J; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, Texas., Frampton G; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, Texas; Central Texas Veterans Health Care System, Temple, Texas., McMillin M; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, Texas; Central Texas Veterans Health Care System, Temple, Texas., DeMorrow S; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, Texas; Central Texas Veterans Health Care System, Temple, Texas. Electronic address: sharon.demorrow@austin.utexas.edu.

Publikováno v: The American journal of pathology [Am J Pathol] 2022 Mar; Vol. 192 (3), pp. 484-502. Date of Electronic Publication: 2021 Dec 08.