T2 heterogeneity: a novel marker of microstructural integrity associated with cognitive decline in people with mild cognitive impairment

Autor: Alfie R. Wearn, Volkan Nurdal, Esther Saunders-Jennings, Michael J. Knight, Hanna K. Isotalus, Serena Dillon, Demitra Tsivos, Risto A. Kauppinen, Elizabeth J. Coulthard

Publikováno v: Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2020)

Abstract Background Early Alzheimer’s disease (AD) diagnosis is vital for development of disease-modifying therapies. Prior to significant brain tissue atrophy, several microstructural changes take place as a result of Alzheimer’s pathology. Thes

Externí odkaz: https://doaj.org/article/fac9fb199eca4558b1f6aa3f07c85b88

T2 heterogeneity: a novel marker of microstructural integrity associated with cognitive decline in people with mild cognitive impairment

Autor: Risto A. Kauppinen, Michael J. Knight, Alfie Wearn, Esther Saunders-Jennings, Demitra Tsivos, Volkan Nurdal, Elizabeth Coulthard, Hanna K. Isotalus, Serena Dillon

Publikováno v: Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2020)
Wearn, A R, Nurdal, V, Saunders-Jennings, E, Knight, M J, Isotalus, H K, Dillon, S, Tsivos, D, Kauppinen, R A & Coulthard, E J 2020, ' T2 heterogeneity : a novel marker of microstructural integrity associated with cognitive decline in people with mild cognitive impairment ', Alzheimer's Research and Therapy, vol. 12, 105 (2020) . https://doi.org/10.1186/s13195-020-00672-9

Background Early Alzheimer’s disease (AD) diagnosis is vital for development of disease-modifying therapies. Prior to significant brain tissue atrophy, several microstructural changes take place as a result of Alzheimer’s pathology. These include

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08964a5b938171e8177775f66937611
https://pubmed.ncbi.nlm.nih.gov/32912337

Quantitative T1 and T2 MRI signal characteristics in the human brain: different patterns of MR contrasts in normal ageing

Autor: Elizabeth Couthard, Bryony McCann, Michael J. Knight, Demitra Tsivos, Risto A. Kauppinen

Publikováno v: Magma (New York, N.y.)
Knight, M, McCann, B, Tsivos, D, Coulthard, E & Kauppinen, R A 2016, ' Quantitative T1 and T2 MRI signal characteristics in the human brain: different patterns of MR contrasts in normal ageing ', Magma, vol. 29, no. 6, pp. 833-842 . https://doi.org/10.1007/s10334-016-0573-0

Objective The objective of this study was to examine age-dependent changes in both T1-weighted and T2-weighted image contrasts and spin-echo T2 relaxation time in the human brain during healthy ageing. Methods A total of 37 participants between the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ad35066640874686d5cf1ea90bdeb0
http://europepmc.org/articles/PMC5124042

The impact of ageing reveals distinct roles for human dentate gyrus and CA3 in pattern separation and object recognition memory

Autor: Catherine Pennington, Margaret Newson, Bryony McCann, Serena Dillon, Anna I. Shiel, Michael J. Knight, Myra E. Conway, Risto A. Kauppinen, Demitra Tsivos, Elizabeth Coulthard

Publikováno v: Dillon, S E, Tsivos, D, Knight, M, Mccann, B, Pennington, C, Shiel, A I, Conway, M E, Newson, M A, Kauppinen, R A & Coulthard, E J 2017, ' The impact of ageing reveals distinct roles for human dentate gyrus and CA3 in pattern separation and object recognition memory ', Scientific Reports, vol. 7, 14069 . https://doi.org/10.1038/s41598-017-13853-8
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Dillon, S, Tsivos, D, Knight, M, McCann, B, Pennington, C, Newson, M, Conway, M, Shiel, A, Kauppinen, R & Coulthard, L 2017, ' The impact of ageing reveals distinct roles for human dentate gyrus and CA3 in pattern separation and object recognition memory. ', Scientific Reports, vol. 7, 14069 . https://doi.org/10.1038/s41598-017-13853-8
Scientific Reports

Both recognition of familiar objects and pattern separation, a process that orthogonalises overlapping events, are critical for effective memory. Evidence is emerging that human pattern separation requires dentate gyrus. Dentate gyrus is intimately c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccbd0d1db863bf95da51de08c534db5
https://hdl.handle.net/20.500.11820/70fdb076-1e3a-4b2a-87f4-7bf22fd92bb1

Quantitative T2 mapping of white matter: applications for ageing and cognitive decline

Autor: Michael J, Knight, Bryony, McCann, Demitra, Tsivos, Serena, Dillon, Elizabeth, Coulthard, Risto A, Kauppinen

Publikováno v: Physics in Medicine and Biology

In MRI, the coherence lifetime T2 is sensitive to the magnetic environment imposed by tissue microstructure and biochemistry in vivo. Here we explore the possibility that the use of T2 relaxometry may provide information complementary to that provide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd4bb8168971a971e00e3e9a3885debd
https://pubmed.ncbi.nlm.nih.gov/27384985