Imbalanced protein expression patterns of anabolic, catabolic, anti-catabolic and inflammatory cytokines in degenerative cervical disc cells: new indications for gene therapeutic treatments of cervical disc diseases.

Autor: Demissew S Mern, Anja Beierfuβ, Johann Fontana, Claudius Thomé, Aldemar A Hegewald

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96870 (2014)

Degenerative disc disease (DDD) of the cervical spine is common after middle age and can cause loss of disc height with painful nerve impingement, bone and joint inflammation. Despite the clinical importance of these problems, in current publications

Externí odkaz: https://doaj.org/article/c27e138069e943a0bdc81b9bc08d2877

Gene ercA, Encoding a Putative Iron-Containing Alcohol Dehydrogenase, Is Involved in Regulation of Ethanol Utilization in Pseudomonas aeruginosa

Autor: Helmut Görisch, Demissew S. Mern, Niels Hempel

Publikováno v: Journal of Bacteriology. 195:3925-3932

Several two-component regulatory systems are known to be involved in the signal transduction pathway of the ethanol oxidation system in Pseudomonas aeruginosa ATCC 17933. These sensor kinases and response regulators are organized in a hierarchical ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0febdc44c1848a3e900efadc8441c0db
https://doi.org/10.1128/jb.00531-13

A complex regulatory network controls aerobic ethanol oxidation in Pseudomonas aeruginosa: indication of four levels of sensor kinases and response regulators

Autor: Helmut Görisch, Demissew S. Mern, Nicole Gliese, Seung-Wook Ha, Viola Khodaverdi

Publikováno v: Microbiology (Reading, England). 156(Pt 5)

In addition to the known response regulator ErbR (former AgmR) and the two-component regulatory system EraSR (former ExaDE), three additional regulatory proteins have been identified as being involved in controlling transcription of the aerobic ethan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac54c296fe2f769f6a88da76705d3c8d
https://pubmed.ncbi.nlm.nih.gov/20093290

Targeting Id1 and Id3 by a specific peptide aptamer induces E-box promoter activity, cell cycle arrest, and apoptosis in breast cancer cells

Autor: Karin Hoppe-Seyler, Barbara Burwinkel, Demissew S. Mern, Felix Hoppe-Seyler, Jens Hasskarl

Publikováno v: Breast Cancer Research and Treatment
Breast Cancer Research and Treatment, Springer Verlag, 2010, 124 (3), pp.623-633. ⟨10.1007/s10549-010-0810-6⟩

Inhibitors of differentiation or DNA binding (Id) proteins have been shown to be involved in tumor growth, invasiveness, metastasis, and angiogenesis. Overexpression of Id proteins, especially Id1, correlates with unfavorable clinical prognosis. Thus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490f4b09a5e32cac5a1962cd60786707
https://pubmed.ncbi.nlm.nih.gov/20191379