Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Demis Menolfi"'
Autor:
Demis Menolfi, Brian J. Lee, Hanwen Zhang, Wenxia Jiang, Nicole E. Bowen, Yunyue Wang, Junfei Zhao, Antony Holmes, Steven Gershik, Raul Rabadan, Baek Kim, Shan Zha
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The ATR kinase, which coordinates cellular responses to DNA replication stress, is also essential for the proliferation of normal unstressed cells. Although its role in the replication stress response is well defined, the mechanisms by which
Externí odkaz:
https://doaj.org/article/d09bbaea5ecb4671897b8a2789d31420
Autor:
Sumedha Agashe, Chinnu Rose Joseph, Teresa Anne Clarisse Reyes, Demis Menolfi, Michele Giannattasio, Anja Waizenegger, Barnabas Szakal, Dana Branzei
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Smc5/6, part of the structural maintenance of chromosomes (SMC) family, plays roles in genome structural integrity. Here the authors reveal that Smc5/6 acts jointly with Top3 within the STR complex to mediate DNA replication completion at genomic nat
Externí odkaz:
https://doaj.org/article/05276fd617f0402ba03a03fa5c996f82
Autor:
Demis Menolfi, Shan Zha
Publikováno v:
Cell & Bioscience, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract DNA damage, especially DNA double strand breaks (DSBs) and replication stress, activates a complex post-translational network termed DNA damage response (DDR). Our review focuses on three PI3-kinase related protein kinases—ATM, ATR and DNA
Externí odkaz:
https://doaj.org/article/d7532f91a2bd46439e665f55aac17bf7
Autor:
Demis Menolfi, Wenxia Jiang, Brian J. Lee, Tatiana Moiseeva, Zhengping Shao, Verna Estes, Mark G. Frattini, Christopher J. Bakkenist, Shan Zha
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
ATR kinase is a key regulator of chromosome integrity. Here the authors by analysing the phenotype of a mouse model expressing a kinase-dead ATR, reveal the effect of ATR inhibition compared to ATR loss and its consequences for meiosis, DNA replicati
Externí odkaz:
https://doaj.org/article/7c2497d431244adcb615e18c3e661a2e
Autor:
Shan Zha, Tanya T. Paull, Peter J. Mckinnon, Dong Wang, Verna M. Estes, Jun Xu, Brian J. Lee, Yang Li, Kenta Yamamoto, Ji-Hoon Lee, Demis Menolfi, Lisa M. Houghton, Maja Milanovic
ATM kinase is a tumor suppressor and a master regulator of the DNA damage response. Most cancer-associated alterations to ATM are missense mutations at the PI3-kinase regulatory domain (PRD) or the kinase domain. Expression of kinase-dead (KD) ATM pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b98792ddd4a9e236a02544fe4fa800a
https://doi.org/10.1158/0008-5472.c.6512610.v1
https://doi.org/10.1158/0008-5472.c.6512610.v1
Autor:
Shan Zha, Tanya T. Paull, Peter J. Mckinnon, Dong Wang, Verna M. Estes, Jun Xu, Brian J. Lee, Yang Li, Kenta Yamamoto, Ji-Hoon Lee, Demis Menolfi, Lisa M. Houghton, Maja Milanovic
Sup. Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875f69e98a19476123d2a783f0cf7c90
https://doi.org/10.1158/0008-5472.22427259.v1
https://doi.org/10.1158/0008-5472.22427259.v1
Autor:
Demis Menolfi, Shan Zha
Publikováno v:
Trends in Cell Biology. 32:91-93
Recent structural studies have revealed the atomic details of how the DNA-PKcs kinase protects DNA ends, recruits and activates Artemis endonuclease for end-processing, and phosphorylates itself for end-ligation, revealing the molecular details from
Autor:
Verna M Estes, Demis Menolfi, Maja Milanovic, Ji-Hoon Lee, Tanya T. Paull, Dong Wang, Yang Li, Lisa M. Houghton, Jun Xu, Brian J. Lee, Peter J. McKinnon, Kenta Yamamoto, Shan Zha
Publikováno v:
Cancer Res
ATM kinase is a tumor suppressor and a master regulator of the DNA damage response. Most cancer-associated alterations to ATM are missense mutations at the PI3-kinase regulatory domain (PRD) or the kinase domain. Expression of kinase-dead (KD) ATM pr
Autor:
Verna M Estes, Riccardo Dalla-Favera, Laura Pasqualucci, Zhengping Shao, Olivia M Cupo, Brian J. Lee, Yimeng Zhu, Richard Baer, Stefanie N. Meyer, Jean Gautier, Foon Wu-Baer, Marco Fangazio, Demis Menolfi, Shan Zha, Yunyue Wang, Xiaobin S Wang
Publikováno v:
Proc Natl Acad Sci U S A
CtIP is a DNA end resection factor widely implicated in alternative end-joining (A-EJ)–mediated translocations in cell-based reporter systems. To address the physiological role of CtIP, an essential gene, in translocation-mediated lymphomagenesis,
Autor:
Demis Menolfi, Shan Zha
Publikováno v:
Genome Instability & Disease. 1:47-68
Genomic integrity is critical for normal development, healthy aging and suppressing oncogenic transformation. The DNA damage response (DDR) is a complex network that is activated by DNA structural changes to preserve genome integrity. Situated at the