Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3.

Autor: Panyard DJ; Department of Genetics, Stanford University School of Medicine, Stanford University, Stanford, California, USA.; Department of Population Health Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Reus LM; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Center for Neurobehavioral Genetics, University of California, Los Angeles, California, USA., Ali M; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, USA., Liu J; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Statistics, University of Wisconsin-Madison, Madison, Wisconsin, USA., Deming YK; Department of Population Health Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Lu Q; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Statistics, University of Wisconsin-Madison, Madison, Wisconsin, USA., Kollmorgen G; Roche Diagnostics GmbH, Penzberg, Germany., Carboni M; Roche Diagnostics International Ltd, Rotkreuz, Switzerland., Wild N; Roche Diagnostics GmbH, Penzberg, Germany., Visser PJ; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Department of Psychiatry, Maastricht University, Maastricht, The Netherlands.; Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden., Bertram L; Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany.; Department of Psychology, University of Oslo, Oslo, Norway., Zetterberg H; Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China., Blennow K; Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Gobom J; Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Western D; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, USA., Sung YJ; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, USA., Carlsson CM; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison, Madison, Wisconsin, USA.; William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA., Johnson SC; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison, Madison, Wisconsin, USA.; William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA., Asthana S; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.; William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, USA., Tijms BM; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., Engelman CD; Department of Population Health Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Snyder MP; Department of Genetics, Stanford University School of Medicine, Stanford University, Stanford, California, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Jul; Vol. 20 (7), pp. 5044-5053. Date of Electronic Publication: 2024 May 29.

Effect of Pathway-specific Polygenic Risk Scores for Alzheimer's Disease (AD) on Rate of Change in Cognitive Function and AD-related Biomarkers among Asymptomatic Individuals.

Autor: Xu Y; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, WI, USA., Vasiljevic E; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, WI, USA.; Center for Demography of Health and Aging, University of Wisconsin-Madison, WI, USA., Deming YK; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, WI, USA.; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, WI, USA.; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison, WI, USA., Jonaitis EM; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison, WI, USA., Koscik RL; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, WI, USA.; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, WI, USA., Van Hulle CA; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, WI, USA., Lu Q; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, WI, USA., Carboni M; Roche Diagnostics International Ltd, Rotkreuz, Switzerland., Kollmorgen G; Roche Diagnostics GmbH, Penzberg, Germany., Wild N; Roche Diagnostics GmbH, Penzberg, Germany., Carlsson CM; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, WI, USA.; Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial VA Hospital, Madison, WI, USA., Johnson SC; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, WI, USA., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; UK Dementia Research Institute at UCL, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Engelman CD; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, WI, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Feb 01. Date of Electronic Publication: 2023 Feb 01.

Liver-Specific Polygenic Risk Score Is Associated with Alzheimer's Disease Diagnosis.

Autor: Panyard DJ; Department of Population Health Sciences, University of Wisconsin-Madison, Madison, WI, USA., Deming YK; Department of Population Health Sciences, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA., Darst BF; Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Van Hulle CA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Kollmorgen G; Roche Diagnostics GmbH, Penzberg, Germany., Suridjan I; Roche Diagnostics International Ltd., Rotkreuz, Switzerland., Carlsson CM; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Johnson SC; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Asthana S; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Engelman CD; Department of Population Health Sciences, University of Wisconsin-Madison, Madison, WI, USA., Lu Q; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.; Department of Statistics, University of Wisconsin-Madison, Madison, WI, USA.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2023; Vol. 92 (2), pp. 395-409.

Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations.

Autor: Panyard DJ; Department of Population Health Sciences, University of Wisconsin-Madison, 610 Walnut Street, 707 WARF Building, Madison, WI, 53726, USA., Kim KM; Department of Biotechnology, Yonsei University, 50 Yonsei-ro Seodaemun-gu, Seoul, 03722, Republic of Korea., Darst BF; Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, 1450 Biggy Street, Los Angeles, CA, 90033, USA., Deming YK; Department of Population Health Sciences, University of Wisconsin-Madison, 610 Walnut Street, 707 WARF Building, Madison, WI, 53726, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, 600 Highland Avenue, J5/1 Mezzanine, Madison, WI, 53792, USA.; Department of Medicine, University of Wisconsin-Madison, 1685 Highland Avenue, 5158 Medical Foundation Centennial Building, Madison, WI, 53705, USA., Zhong X; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, WARF Room 201, 610 Walnut Street, Madison, WI, 53726, USA., Wu Y; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, WARF Room 201, 610 Walnut Street, Madison, WI, 53726, USA., Kang H; Department of Statistics, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI, 53706, USA., Carlsson CM; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, 600 Highland Avenue, J5/1 Mezzanine, Madison, WI, 53792, USA.; Department of Medicine, University of Wisconsin-Madison, 1685 Highland Avenue, 5158 Medical Foundation Centennial Building, Madison, WI, 53705, USA.; William S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI, 53705, USA., Johnson SC; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, 600 Highland Avenue, J5/1 Mezzanine, Madison, WI, 53792, USA.; Department of Medicine, University of Wisconsin-Madison, 1685 Highland Avenue, 5158 Medical Foundation Centennial Building, Madison, WI, 53705, USA.; William S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI, 53705, USA., Asthana S; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, 600 Highland Avenue, J5/1 Mezzanine, Madison, WI, 53792, USA.; Department of Medicine, University of Wisconsin-Madison, 1685 Highland Avenue, 5158 Medical Foundation Centennial Building, Madison, WI, 53705, USA.; William S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI, 53705, USA., Engelman CD; Department of Population Health Sciences, University of Wisconsin-Madison, 610 Walnut Street, 707 WARF Building, Madison, WI, 53726, USA., Lu Q; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, WARF Room 201, 610 Walnut Street, Madison, WI, 53726, USA. qlu@biostat.wisc.edu.; Department of Statistics, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI, 53706, USA. qlu@biostat.wisc.edu.

Publikováno v: Communications biology [Commun Biol] 2021 Jan 12; Vol. 4 (1), pp. 63. Date of Electronic Publication: 2021 Jan 12.