Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Deming Chau"'
Autor:
Marta Gómez-Nuñez, Kurtis J Haro, Tao Dao, Deming Chau, Annie Won, Sindy Escobar-Alvarez, Victoriya Zakhaleva, Tatyana Korontsvit, David Y Gin, David A Scheinberg
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3938 (2008)
Wilms tumor protein (WT1) is a transcription factor selectively overexpressed in leukemias and cancers; clinical trials are underway that use altered WT1 peptide sequences as vaccines. Here we report a strategy to study peptide-MHC interactions by in
Externí odkaz:
https://doaj.org/article/30d4d05cd0184de5a54cb2a7878f3a05
Akademický článek
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Autor:
Hakim Djaballah, Yue-Ming Li, David Shum, Deming Chau, Bhavneet Bhinder, Constantin Radu, David Y. Gin, M. Lane Gilchrist
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 16:415-424
The Notch pathway plays a crucial role in cell fate decisions through controlling various cellular processes. Overactive Notch signal contributes to cancer development from leukemias to solid tumors. γ-Secretase is an intramembrane protease responsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c95ba4f78b4bb326f9e41c47e075ed57
https://doi.org/10.2174/1386207311316060001
https://doi.org/10.2174/1386207311316060001
Autor:
Christopher C. Shelton, Deming Chau, Lei Zhu, Li Yang, Yue-Ming Li, Hakim Djaballah, Rong Wang, Hui Zheng
Publikováno v:
Proceedings of the National Academy of Sciences. 106:20228-20233
gamma-Secretase cleaves multiple substrates within the transmembrane domain that include the amyloid precursor protein as well as the Notch family of receptors. These substrates are associated with Alzheimer disease and cancer. Despite extensive inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788898118680a4752e4da1e9e95de696
https://doi.org/10.1073/pnas.0910757106
https://doi.org/10.1073/pnas.0910757106
Publikováno v:
The Journal of biological chemistry. 287(21)
Presenilin-1 (PS1) is the catalytic subunit of γ-secretase, and mutations in this protein cause familial Alzheimer Disease (FAD). However, little is known about how these mutations affect the active site of γ-secretase. Here, we show that PS1 mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6de9ad26518ae1f247489ac0c9eacf
https://pubmed.ncbi.nlm.nih.gov/22461631
https://pubmed.ncbi.nlm.nih.gov/22461631
Publikováno v:
Nature structuralmolecular biology. 17(2)
Gamma-secretase is an aspartyl protease that cleaves multiple substrates within their transmembrane domains. Gamma-secretase processes the amyloid precursor protein (APP) to generate gamma-amyloid (Agamma) peptides associated with Alzheimer's disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979bcf73ce3c0f7118ac9ec6aafef834
https://pubmed.ncbi.nlm.nih.gov/20130572
https://pubmed.ncbi.nlm.nih.gov/20130572
Autor:
Sindy Escobar-Alvarez, Kurtis J. Haro, Annie Won, David A. Scheinberg, Tatyana Korontsvit, Marta Gómez-Nuñez, David Y. Gin, Tao Dao, Victoriya Zakhaleva, Deming Chau
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3938 (2008)
PLoS ONE
PLoS ONE
Wilms tumor protein (WT1) is a transcription factor selectively overexpressed in leukemias and cancers; clinical trials are underway that use altered WT1 peptide sequences as vaccines. Here we report a strategy to study peptide-MHC interactions by in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e153ec0e099ffc39ce78554f8430e62c
http://europepmc.org/articles/PMC2592539?pdf=render
http://europepmc.org/articles/PMC2592539?pdf=render
Autor:
Tatyana Korontsvit, Kurtis J. Haro, David A. Scheinberg, Tao Dao, Victoriya Zakhaleva, Sindy Escobar-Alvarez, David Y. Gin, Annie Won, Marta Gómez-Nuñez, Deming Chau
Publikováno v:
Blood. 110:2311-2311
Wilms tumor protein (WT1) is a transcription factor selectively over expressed in several types of leukemia and solid tumors, making it a promising potential target antigen for immunotherapy. Several open clinical trials use native or altered peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feda20d82753962ac1700373dc7aa3b9
https://doi.org/10.1182/blood.v110.11.2311.2311
https://doi.org/10.1182/blood.v110.11.2311.2311
Publikováno v:
Nature Structural & Molecular Biology; Feb2010, Vol. 17 Issue 2, p151-158, 8p, 1 Diagram, 6 Graphs
Autor:
SheIton, Christopher C., Lei Zhu, Deming Chau, Li Yang, Rong Wang, Hakim Djaballah, Hui Zheng, Yue-Ming Li
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 12/1/2009, Vol. 106 Issue 48, p20228-20233, 7p