Development of an enhanced bovine viral diarrhea virus subunit vaccine based on E2 glycoprotein fused to a single chain antibody which targets to antigen-presenting cells

Autor: Andrea Pecora, Darío A Malacari, María S Pérez Aguirreburualde, Demian Bellido, José M Escribano, María J. Dus Santos, Andrés Wigdorovitz

Publikováno v: Revista Argentina de Microbiología, Vol 47, Iss 1, Pp 4-8 (2015)

Bovine viral diarrhea virus (BVDV) is an important cause of economic losses worldwide. E2 is an immunodominant protein and a promising candidate to develop subunit vaccines. To improve its immunogenicity, a truncated E2 (tE2) was fused to a single ch

Externí odkaz: https://doaj.org/article/f5f9b1f2f20b487585b2948506b28d10

Rational design of the first commercially available subunit vaccine against BVDV targeted to immune system cells

Autor: José M. Escribano, Lucia Rocha, Demian Bellido, Josefina Baztarrica, Andrés Wigdorovitz, Viviana Parreño, Andrea Pecora, Mario Acosta

Bovine viral diarrhea virus (BVDV) is a major cause of economic loss in the cattle industry, worldwide. Infection results in reduce productive performance, growth retardation, reduced milk production, and increased susceptibility to other diseases le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e4c72c3e967f98f9ea32d291da40552
https://doi.org/10.22541/au.159819293.39050345

Expression of the multimeric and highly immunogenic brucella spp. Lumazine synthase fused to bovine rotavirus VP8D as a scaffold for antigen production in tobacco chloroplasts

Autor: Ezequiel Lentz, María José Dus Santos, Andrés Wigdorovitz, Fernando Bravo-Almonacid, E. Federico Alfano, Fernando Alberto Goldbaum, Demian Bellido

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Plant Science, Vol 6 (2015)
Frontiers in Plant Science

Lumazine synthase from Brucella spp. (BLS) is a highly immunogenic decameric protein which can accommodate foreign polypeptides or protein domains fused to its N-termini, markedly increasing their immunogenicity. The inner core domain (VP8d) of VP8 s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f08ed533d32db34d7dcefa9b022485f
https://www.frontiersin.org/articles/10.3389/fpls.2015.01170/full

Development of an APC-targeted multivalent E2-based vaccine against Bovine Viral Diarrhea Virus types 1 and 2

Autor: Andrés Wigdorovitz, Andrea Pecora, J.M. Escribano, Darío Amilcar Malacari, Demian Bellido, M.J. Dus Santos, Maria del Carmen Nuñez, M.S. Perez Aguirreburualde

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Repositorio de Resultados de Investigación del INIA
INIA: Repositorio de Resultados de Investigación del INIA
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA

The aim of this study was to develop and test a multivalent subunit vaccine against Bovine Viral Diarrhea Virus (BVDV) based on the E2 virus glycoprotein belonging to genotypes 1a, 1b and 2a, immunopotenti- ated by targeting these antigens to antigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587d80c84873dc1a473849985568da2f
https://www.sciencedirect.com/science/article/pii/S0264410X15011147

Brucella spp. Lumazine synthase as a novel immunomodulator to produce egg yolk antibodies

Autor: Marina Valeria Mozgovoj, Diego Daniel Gonzalez, Fernando Alberto Goldbaum, Pablo Chacana, Demian Bellido, María José Dus Santos, Andrés Wigdorovitz

Publikováno v: Advances in Bioscience and Biotechnology 3 (1) : 80-86 (February 2012)
INTA Digital (INTA)
Instituto Nacional de Tecnología Agropecuaria
instacron:INTA

Lumazine synthase from Brucella spp. (BLS) is a highly immunogenic decameric protein. It has been previously described as a carrier of peptides or proteins to increase their immunogenicity in different animal species, but its activity has never been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2b2c08b4c31c5f022d3044df22827a
https://www.scirp.org/journal/PaperInformation.aspx?PaperID=17200