Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology.

Autor: Cope H; School of Medicine, University of Nottingham, Derby, DE22 3DT, UK., Elsborg J; Department of Energy Conversion and Storage, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.; Abzu, Copenhagen, 2150, Denmark., Demharter S; Abzu, Copenhagen, 2150, Denmark., McDonald JT; Department of Radiation Medicine, School of Medicine, Georgetown University, Washington D.C., WA, 20057, USA., Wernecke C; NASA GeneLab For High Schools Program (GL4HS), Space Biology Program, NASA Ames Research Center, Moffett Field, CA, USA.; Department of Aerospace and Geodesy, TUM School of Engineering and Design, Technical University of Munich, Munich, Germany., Parthasarathy H; NASA GeneLab For High Schools Program (GL4HS), Space Biology Program, NASA Ames Research Center, Moffett Field, CA, USA.; College of Engineering and Haas School of Business, University of California, Berkeley, Berkeley, CA, 94720, USA., Unadkat H; NASA GeneLab For High Schools Program (GL4HS), Space Biology Program, NASA Ames Research Center, Moffett Field, CA, USA.; School of Engineering and Applied Science, Princeton University, Princeton, NJ, 08540, USA., Chatrathi M; NASA GeneLab For High Schools Program (GL4HS), Space Biology Program, NASA Ames Research Center, Moffett Field, CA, USA.; College of Letters and Science, University of California, Berkeley, Berkeley, CA, 94720, USA., Claudio J; NASA GeneLab For High Schools Program (GL4HS), Space Biology Program, NASA Ames Research Center, Moffett Field, CA, USA.; Blue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research Center, Moffett field, CA, USA., Reinsch S; NASA GeneLab For High Schools Program (GL4HS), Space Biology Program, NASA Ames Research Center, Moffett Field, CA, USA.; Space Biosciences Division, NASA Ames Research Center, Moffett field, CA, USA., Avci P; Department of Dermatology and Allergy, University Hospital, LMU Munich, 80337, Munich, Germany., Zwart SR; University of Texas Medical Branch, Galveston, TX, USA., Smith SM; Biomedical Research and Environmental Sciences Division, Human Health and Performance Directorate, NASA Johnson Space Center, Houston, TX, 77058, USA., Heer M; IU International University of Applied Sciences, Erfurt and University of Bonn, Bonn, Germany., Muratani M; Transborder Medical Research Center, University of Tsukuba, Ibaraki, 305-8575, Japan.; Department of Genome Biology, Institute of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan., Meydan C; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA., Overbey E; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA., Kim J; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA., Chin CR; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA., Park J; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA.; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, 10065, USA., Schisler JC; McAllister Heart Institute and Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Mason CE; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA.; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, 10065, USA., Szewczyk NJ; School of Medicine, University of Nottingham, Derby, DE22 3DT, UK.; Ohio Musculoskeletal and Neurological Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, 45701, USA., Willis CRG; School of Chemistry and Biosciences, Faculty of Life Sciences, University of Bradford, Bradford, BD7 1DP, UK., Salam A; St John's Institute of Dermatology, King's College London, Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK., Beheshti A; Blue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research Center, Moffett field, CA, USA. afshin.beheshti@nasa.gov.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. afshin.beheshti@nasa.gov.

Publikováno v: Communications medicine [Commun Med (Lond)] 2024 Jun 11; Vol. 4 (1), pp. 106. Date of Electronic Publication: 2024 Jun 11.

Large-scale data mining of four billion human antibody variable regions reveals convergence between therapeutic and natural antibodies that constrains search space for biologics drug discovery.

Autor: Dudzic P; NaturalAntibody, Szczecin, Poland., Chomicz D; NaturalAntibody, Szczecin, Poland., Kończak J; NaturalAntibody, Szczecin, Poland., Satława T; NaturalAntibody, Szczecin, Poland., Janusz B; NaturalAntibody, Szczecin, Poland., Wrobel S; NaturalAntibody, Szczecin, Poland., Gawłowski T; NaturalAntibody, Szczecin, Poland., Jaszczyszyn I; NaturalAntibody, Szczecin, Poland., Bielska W; NaturalAntibody, Szczecin, Poland., Demharter S; Discovery Data Science, Genmab, Copenhagen, Denmark., Spreafico R; Discovery Data Science, Genmab, Utrecht, The Netherlands., Schulte L; Global Computational Biology & Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany., Martin K; Biotherapeutics Discovery, Boehringer Ingelheim, Ridgefield, CT, USA., Comeau SR; Biotherapeutics Discovery, Boehringer Ingelheim, Ridgefield, CT, USA., Krawczyk K; NaturalAntibody, Szczecin, Poland.

Publikováno v: MAbs [MAbs] 2024 Jan-Dec; Vol. 16 (1), pp. 2361928. Date of Electronic Publication: 2024 Jun 06.

Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts.

Autor: Guarnieri JW; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Dybas JM; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Fazelinia H; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Kim MS; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA .; Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, South Korea., Frere J; Icahn School of Medicine at Mount Sinai, New York, NY 10023, USA., Zhang Y; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Soto Albrecht Y; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Murdock DG; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Angelin A; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Singh LN; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Weiss SL; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Best SM; COVID-19 International Research Team, Medford, MA 02155, USA .; Rocky Mountain Laboratory, National Institute of Allergy and Infectious Disease, NIH, Hamilton, MT 59840, USA., Lott MT; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Zhang S; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Cope H; University of Nottingham, Nottingham, UK., Zaksas V; COVID-19 International Research Team, Medford, MA 02155, USA .; University of Chicago, Chicago, IL 60615, USA.; Clever Research Lab, Springfield, IL 62704, USA., Saravia-Butler A; COVID-19 International Research Team, Medford, MA 02155, USA .; Logyx, LLC, Mountain View, CA 94043, USA.; NASA Ames Research Center, Moffett Field, CA 94035, USA., Meydan C; COVID-19 International Research Team, Medford, MA 02155, USA .; Weill Cornell Medicine, New York, NY 10065, USA., Foox J; Weill Cornell Medicine, New York, NY 10065, USA., Mozsary C; Weill Cornell Medicine, New York, NY 10065, USA., Bram Y; Weill Cornell Medicine, New York, NY 10065, USA., Kidane Y; COVID-19 International Research Team, Medford, MA 02155, USA .; Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA., Priebe W; COVID-19 International Research Team, Medford, MA 02155, USA .; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Emmett MR; COVID-19 International Research Team, Medford, MA 02155, USA .; University of Texas Medical Branch, Galveston, TX 77555, USA., Meller R; COVID-19 International Research Team, Medford, MA 02155, USA .; Morehouse School of Medicine, Atlanta, GA 30310, USA., Demharter S; DKAbzu ApS, Copenhagen 2150, Denmark., Stentoft-Hansen V; DKAbzu ApS, Copenhagen 2150, Denmark., Salvatore M; DKAbzu ApS, Copenhagen 2150, Denmark., Galeano D; COVID-19 International Research Team, Medford, MA 02155, USA .; Facultad de Ingeniería, Universidad Nacional de Asunción, San Lorenzo, Central, Paraguay., Enguita FJ; COVID-19 International Research Team, Medford, MA 02155, USA .; Faculdade de Medicina, Universidade de Lisboa, Instituto de Medicina Molecular João Lobo Antunes, 1649-028 Lisboa, Portugal., Grabham P; College of Physicians and Surgeons, Columbia University, New York, NY 19103, USA., Trovao NS; COVID-19 International Research Team, Medford, MA 02155, USA .; Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA., Singh U; COVID-19 International Research Team, Medford, MA 02155, USA .; Iowa State University, Ames, IA 50011, USA., Haltom J; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA .; Iowa State University, Ames, IA 50011, USA., Heise MT; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Moorman NJ; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Baxter VK; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Madden EA; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Taft-Benz SA; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Anderson EJ; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Sanders WA; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Dickmander RJ; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Baylin SB; COVID-19 International Research Team, Medford, MA 02155, USA .; Johns Hopkins School of Medicine, Baltimore, MD 21287, USA., Wurtele ES; COVID-19 International Research Team, Medford, MA 02155, USA .; Iowa State University, Ames, IA 50011, USA., Moraes-Vieira PM; COVID-19 International Research Team, Medford, MA 02155, USA .; University of Campinas, Campinas, SP, Brazil., Taylor D; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Mason CE; COVID-19 International Research Team, Medford, MA 02155, USA .; Weill Cornell Medicine, New York, NY 10065, USA.; New York Genome Center, New York, NY 10013, USA., Schisler JC; COVID-19 International Research Team, Medford, MA 02155, USA .; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Schwartz RE; COVID-19 International Research Team, Medford, MA 02155, USA .; Weill Cornell Medicine, New York, NY 10065, USA., Beheshti A; COVID-19 International Research Team, Medford, MA 02155, USA .; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA., Wallace DC; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA .; Division of Human Genetics, Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Aug 09; Vol. 15 (708), pp. eabq1533. Date of Electronic Publication: 2023 Aug 09.

Multi-omic analyses of triptan-treated migraine attacks gives insight into molecular mechanisms.

Autor: Kogelman LJA; Department of Neurology, Danish Headache Center, Copenhagen University Hospital, Glostrup, Denmark. lisette.kogelman@regionh.dk., Falkenberg K; Department of Neurology, Danish Headache Center, Copenhagen University Hospital, Glostrup, Denmark., Ottosson F; Department of Congenital Disorders, Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark., Ernst M; Department of Congenital Disorders, Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark., Russo F; Department of Congenital Disorders, Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark., Stentoft-Hansen V; Abzu ApS, Copenhagen, Denmark., Demharter S; Abzu ApS, Copenhagen, Denmark., Tfelt-Hansen P; Department of Neurology, Danish Headache Center, Copenhagen University Hospital, Glostrup, Denmark., Cohen AS; Department of Congenital Disorders, Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark., Olesen J; Department of Neurology, Danish Headache Center, Copenhagen University Hospital, Glostrup, Denmark., Hansen TF; Department of Neurology, Danish Headache Center, Copenhagen University Hospital, Glostrup, Denmark.; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: Scientific reports [Sci Rep] 2023 Jul 31; Vol. 13 (1), pp. 12395. Date of Electronic Publication: 2023 Jul 31.

Dissection of gastric homeostasis in vivo facilitates permanent capture of isthmus-like stem cells in vitro.

Autor: Huebner AJ; Massachusetts General Hospital Department of Molecular Biology, Boston, MA, USA.; Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, Boston, MA, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA., Gorelov RA; Massachusetts General Hospital Department of Molecular Biology, Boston, MA, USA.; Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, Boston, MA, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA., Deviatiiarov R; Institute of Fundamental Medicine and Biology, Kazan Feberal University, Kazan, Russia., Demharter S; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Kull T; Massachusetts General Hospital Department of Molecular Biology, Boston, MA, USA.; Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, Boston, MA, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA., Walsh RM; Massachusetts General Hospital Department of Molecular Biology, Boston, MA, USA.; Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, Boston, MA, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA., Taylor MS; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Steiger S; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Mullen JT; Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Kharchenko PV; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. Peter.Kharchenko@post.harvard.edu.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. Peter.Kharchenko@post.harvard.edu.; San Diego Institute, Altos Labs, San Diego, CA, USA. Peter.Kharchenko@post.harvard.edu., Hochedlinger K; Massachusetts General Hospital Department of Molecular Biology, Boston, MA, USA. hochedlinger@molbio.mgh.harvard.edu.; Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, Boston, MA, USA. hochedlinger@molbio.mgh.harvard.edu.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. hochedlinger@molbio.mgh.harvard.edu.

Publikováno v: Nature cell biology [Nat Cell Biol] 2023 Mar; Vol. 25 (3), pp. 390-403. Date of Electronic Publication: 2023 Jan 30.