Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Demetrius Moskophidis"'
Autor:
Nahid F. Mivechi, Demetrius Moskophidis, Caixia Xi, Xiongjie Jin, Junfeng Pang, Binnur Eroglu
Figure S1. Hsf1 loss significantly reduced human T-ALL cell survival. Figure S2. Pharmacological inhibitors of the HSF1 pathway exhibit potent antitumor activity in human T-ALL cell lines. Figure S3. HSF1 knockdown in human T-ALL cell lines reduces t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b1b74a9591271b9ebaec225bffb9bc
https://doi.org/10.1158/1541-7786.22513722
https://doi.org/10.1158/1541-7786.22513722
Autor:
Binnur Eroglu, Xiongjie Jin, Sadiki Deane, Bahadır Öztürk, Owen A. Ross, Demetrius Moskophidis, Nahid F. Mivechi
Publikováno v:
Cellular and molecular life sciences : CMLS. 79(4)
The dual specificity protein phosphatases (Dusps) control dephosphorylation of mitogen-activated protein kinases (MAPKs) as well as other substrates. Here, we report that Dusp26, which is highly expressed in neuroblastoma cells and primary neurons is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1694a041505b14f514a1d5e3a08f48ec
https://pubmed.ncbi.nlm.nih.gov/35313355
https://pubmed.ncbi.nlm.nih.gov/35313355
Publikováno v:
The Journal of Cell Biology
How cells sense energetic demands and regulate their bioenergetic networks to balance anabolism and catabolism is unclear. Qiao et al show that HSF1, a regulator of the chaperone response, has a central role in systemic energy sensing and is required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c80cdd6d634d5e1cf83b5c8618716c9
http://europepmc.org/articles/PMC5350514
http://europepmc.org/articles/PMC5350514
Autor:
Caixia Xi, Nahid F. Mivechi, Demetrius Moskophidis, Junfeng Pang, Xiongjie Jin, Binnur Eroglu
Publikováno v:
Mol Cancer Res
Deregulated oncogenic signaling linked to PI3K/AKT and mTORC1 pathway activation is a hallmark of human T-cell acute leukemia (T-ALL) pathogenesis and contributes to leukemic cell resistance and adverse prognosis. Notably, although the multiagent che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671723e438247b5ada2407fe642411bb
https://europepmc.org/articles/PMC7056558/
https://europepmc.org/articles/PMC7056558/
Publikováno v:
Molecular and Cellular Biology. 39
Delineating the mechanisms that drive hepatic injury and hepatocellular carcinoma (HCC) progression is critical for development of novel treatments for recurrent and advanced HCC but also for the development of diagnostic and preventive strategies. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e3d933026f742ba893b43927f740d2
https://doi.org/10.1128/mcb.00391-18
https://doi.org/10.1128/mcb.00391-18
Publikováno v:
The Journal of Immunology. 204:240.7-240.7
Heat Shock Factor 1 (HSF1) is transcriptionally activated in response to a variety of environmental stressors. Data from our laboratory indicates that genetic inactivation of HSF1 significantly delays tumorigenesis in various tumor models. Increasing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7566d8632af61c8b540c6ac0b38be78b
https://doi.org/10.4049/jimmunol.204.supp.240.7
https://doi.org/10.4049/jimmunol.204.supp.240.7
Publikováno v:
Molecular and cellular biology. 38(18)
Activation of the adaptive response to cellular stress orchestrated by heat shock factor 1 (HSF1), which is an evolutionarily conserved transcriptional regulator of chaperone response and cellular bioenergetics in diverse model systems, is a central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e157e54429d90512e5a665512587b9b
https://pubmed.ncbi.nlm.nih.gov/29941492
https://pubmed.ncbi.nlm.nih.gov/29941492
Publikováno v:
Journal of Biological Chemistry. 287:35646-35657
ErbB2/Neu oncogene is overexpressed in 25% of invasive/metastatic breast cancers. We have found that deletion of heat shock factor Hsf1 in mice overexpressing ErbB2/Neu significantly reduces mammary tumorigenesis and metastasis. Hsf1(+/-)ErbB2/Neu(+)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90ac3dafea95c25394c4686d22097ce
https://doi.org/10.1074/jbc.m112.377481
https://doi.org/10.1074/jbc.m112.377481
Publikováno v:
Cell Metabolism. 14(1):91-103
SummaryHepatocellular carcinoma (HCC) occurrence and progression are linked tightly to progressive hepatic metabolic syndrome associated with insulin resistance, hepatic steatosis, and chronic inflammation. Heat shock transcription factor 1 (HSF1), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66aba1489832193de12e24ebcd243f8
Publikováno v:
Molecular and Cellular Biology. 30:4626-4643
Diseases like Alzheimer's disease (AD) and other tauopathies are defined by the expression of neurofibrillary tangles (NFTs) deposited mainly in neurons. The NFTs are aggregates of the hyperphosphorylated tau (p-tau) (3, 74). Normal tau increases mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb4953f2f76f2888cd4c637d3928576
https://doi.org/10.1128/mcb.01493-09
https://doi.org/10.1128/mcb.01493-09