Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Demetrius A. Vouyiouklis"'
Autor:
Brian J. Morris, Robert W. Hunter, Hiromitsu Ohzeki, Catherine L Winchester, John Norrie, Demetrius A. Vouyiouklis, Keiji Yamagami, Josef M. Penninger, Rhiannon Thompson, Judith A. Pratt
Publikováno v:
Human Molecular Genetics. 21:4910-4921
Schizophrenia is a debilitating psychiatric disease with a strong genetic contribution, potentially linked to altered glutamatergic function in brain regions such as the prefrontal cortex (PFC). Here, we report converging evidence to support a functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b34339c0d47385daf3a28440418ca7c
https://doi.org/10.1093/hmg/dds331
https://doi.org/10.1093/hmg/dds331
Autor:
Gavin J. Clowry, Subrot Sarma, Nadhim Bayatti, Janet Eyre, Christopher Shaw, Demetrius A. Vouyiouklis, Susan Lindsay
Publikováno v:
The European Journal of Neuroscience
The transcription factors Emx2 and Pax6 are expressed in the proliferating zones of the developing rodent neocortex, and gradients of expression interact in specifying caudal and rostral identities. Pax6 is also involved in corticoneurogenesis, being
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034d110bc5076c666c03429978ba3fda
https://doi.org/10.1111/j.1460-9568.2008.06475.x
https://doi.org/10.1111/j.1460-9568.2008.06475.x
Autor:
Jennifer A. Barrie, Christine E. Thomson, K.N. Wease, Paul Montague, Demetrius A. Vouyiouklis
Publikováno v:
Developmental Neuroscience. 27:27-36
The factors regulating the expression and splicing of the major myelin gene, proteolipid protein (Plp), are unclear. The gene encodes two splice variants, Plp and Dm20. During active myelination, transcription of the Plp gene is markedly upregulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f81e822c45dfa82a1d8efa7ea089b0e8
https://doi.org/10.1159/000084530
https://doi.org/10.1159/000084530
Publikováno v:
Genomics. 83:225-230
Hindshaker (hsh), a spontaneous, autosomal recessive mouse mutation, displays a developmentally dependent tremor of the hindquarters due to hypomyelination in the CNS. This myelin deficit is followed by progressive, but incomplete, recovery by postna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ab2fdedc676398855f0cc1dcd45086
https://doi.org/10.1016/j.ygeno.2003.08.014
https://doi.org/10.1016/j.ygeno.2003.08.014
Publikováno v:
Journal of Neurochemistry. 69:995-1005
Two isoforms of the Ca2+-sensitive, actin-binding protein gelsolin have been identified thus far; one is an intracellular protein, cytoplasmic gelsolin, and the other is a secretory protein called plasma gelsolin. Gelsolin expression in the mammalian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99d7bf6c3fd4616b67fb4211836d30f
https://doi.org/10.1046/j.1471-4159.1997.69030995.x
https://doi.org/10.1046/j.1471-4159.1997.69030995.x
Autor:
Donald Yool, Klaus-Armin Nave, L Dimou, Demetrius A. Vouyiouklis, Jennifer A. Barrie, M. C. McCulloch, Marie McLaughlin, Matthias Klugmann, Ian R. Griffiths
Publikováno v:
Journal of Neuroscience Research. 63:151-164
Although proteolipid protein (PLP) and its DM20 isoform are the major membrane proteins of CNS myelin, their absence causes surprisingly few developmental defects. In comparison, missense mutations of the X-linked Plp gene cause severe dysmyelination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1d6bdf36efacf4458d7d000328edd44
https://doi.org/10.1002/1097-4547(20010115)63:2<151::aid-jnr1007>3.0.co
https://doi.org/10.1002/1097-4547(20010115)63:2<151::aid-jnr1007>3.0.co
Autor:
Peter J Dickinson, Christine E. Thomson, M. C. McCulloch, Demetrius A. Vouyiouklis, Thomas J. Anderson, Ian R. Griffiths
Publikováno v:
Journal of Neurocytology. 28:207-221
The jimpy mutation of the X-linked proteolipid protein (Plp) gene causes dysmyelination and premature death of the mice. The established phenotype is characterised by severe hypomyelination, increased numbers of dead oligodendrocytes and astrocytosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed750aa1014691a707956d2f6286e5e1
https://doi.org/10.1023/a:1007024022663
https://doi.org/10.1023/a:1007024022663
Autor:
Christine E. Thomson, Ian R. Griffiths, Demetrius A. Vouyiouklis, Klaus Armin-Nave, Gregor J. Stewart, Hauke B. Werner
Publikováno v:
Journal of Neuroscience Research. 52:633-640
The present study documents the nucleic acid and deduced amino acid sequence of M6b-2, a novel splice variant of the M6b gene, which belongs to the PLP-DM20/M6 gene family. M6b-2 differs from the previously published M6b by a novel 40-amino acid inse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2613c56af4d75ddfe3c69f986723e830
https://doi.org/10.1002/(sici)1097-4547(19980615)52:6<633::aid-jnr2>3.0.co
https://doi.org/10.1002/(sici)1097-4547(19980615)52:6<633::aid-jnr2>3.0.co
Autor:
Thomas J. Anderson, Demetrius A. Vouyiouklis, Christine E. Thomson, Ian R. Griffiths, Klaus-Armin Nave, Matthias Klugmann
Publikováno v:
Microscopy Research and Technique. 41:344-358
Proteolipid protein (PLP) and its smaller isoform DM20 constitute the major myelin proteins of the CNS. Mutations of the X-linked Plp gene cause the heterogeneous syndromes of Pelizaeus-Merzbacher disease (PMD) and spastic paraplegia (SPG) in man and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6b23f1a4b4b421503f667d6c6095372
https://doi.org/10.1002/(sici)1097-0029(19980601)41:5<344::aid-jemt2>3.0.co
https://doi.org/10.1002/(sici)1097-0029(19980601)41:5<344::aid-jemt2>3.0.co
Publikováno v:
Journal of neurochemistry. 74(3)
Alternative splicing of the precursor for messenger RNA (pre-mRNA) is a common process utilised by higher eukaryotes to modulate gene expression. A single primary transcript may generate several proteins with distinct functions, expressed in tissue-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b7e14c274123407743a8133cfc8d89
https://pubmed.ncbi.nlm.nih.gov/10693924
https://pubmed.ncbi.nlm.nih.gov/10693924