Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Demetris N. Zambas"'
Autor:
Patrick S Zbyszewski, Susan L Krikorian, Carl F. Pieper, Tim E Breen, Meredith N. Zozus, Leigh R Smith, Debra A Jendrasek, Demetris N Zambas, Derek C Perrin, Tremaine B. Williams, Shelly K Knoll, Angel Lazarov
Publikováno v:
Journal of the American Medical Informatics Association : JAMIA. 24(4)
Objective: To assess and refine competencies for the clinical research data management profession. Materials and Methods: Based on prior work developing and maintaining a practice standard and professional certification exam, a survey was administere
Publikováno v:
Therapeutic Drug Monitoring. 22:555-565
The population pharmacokinetics of ribavirin were assessed in patients with chronic hepatitis C virus (HCV) infection treated with interferon alpha-2b and ribavirin in four clinical efficacy studies. The authors collected 3450 ribavirin serum concent
Autor:
Demetris N. Zambas, Margaret Salfi, Samir K. Gupta, Steven Schenker, Robert P. Clement, Paul Glue
Publikováno v:
British Journal of Clinical Pharmacology. 49:417-421
Aims The primary objective of this study was to describe the single dose pharmacokinetics of ribavirin in subjects with normal liver function and those with various degrees of stable chronic liver disease. Additionally this study assessed the safety
Autor:
Samuel Heft, Vijay Batra, Sudhakar Pai, J. Frank Jen, Melton B. Affrime, Demetris N. Zambas, Gerald Hajian, David L. Cutler
Publikováno v:
Pharmaceutical Research. 17:1284-1289
Purpose. To evaluate covariate effects on the pharmacokinetics of temozolomide in cancer patients, and to explore the dose-pharmacokinetics-toxicity relationship of temozolomide.
Autor:
Kimberly S. Stranick, M. Motasim Billah, Annette S. Uss, Robert W. Egan, Demetris N. Zambas, Shelby P. Umland
Publikováno v:
Biochemical and Biophysical Research Communications. 252:56-62
The proximal mouse IL-5 promoter was examined using a mouse TH2 clone stimulated through the T cell receptor using anti-CD3 monoclonal antibody. DNase I protection defined four protein binding regions [IL-5RE-A, -69/-45; -B, (-90/-76); -C, (-154/-130
Autor:
Annette S. Uss, M. Motasim Billah, Robert W. Egan, Kimberly S. Stranick, Demetris N. Zambas, Shelby P. Umland
Publikováno v:
Journal of Biological Chemistry. 272:16453-16465
This study identifies three regions of the human interleukin (IL)-5 promoter involved in binding nuclear factors from activated T cells. DNase I footprinting and mobility shift assays with nuclear proteins from the human T cell clone, SP-B21, demonst
Autor:
Daniel M. Solomon, Pauline C. Ting, Sidney R. Smith, Demetris N. Zambas, James Jakway, Carol Terminelli, Joe F. Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2749-2754
2-[10,11-Dihydro-5-ethoxy-5 H -dibenzo[a,d]cyclohepten-5-yl]-N,N-dimethyl-ethanamine (1) has been found to possess anticytokine activity. The synthesis and structure-activity relationship study of a series of analogues are reported.
Autor:
John G. McHutchison, Janice K. Albrecht, Paul Glue, Gianluigi Gianelli, Michael Elliot, Demetris N. Zambas, Lisa M. Nyberg, Andrew Conrad
Publikováno v:
Journal of clinical gastroenterology. 28(4)
Ribavirin, a nucleoside analogue, inhibits replication of RNA and DNA viruses and may control hepatitis C virus (HCV) infection through modulation of anti-inflammatory and antiviral actions. Ribavirin monotherapy has no effect on serum HCV RNA levels
Autor:
M. Motasim Billah, Demetris N. Zambas, Robert W. Egan, Faribourz Payvandi, Kimberly S. Stranick, Shelby P. Umland
Publikováno v:
The Journal of biological chemistry. 270(35)
Cis-acting regions in the 5′-flank of the mouse interleukin 5 (IL-5) gene involved in the specific and inducible regulation of IL-5 transcription in an untransformed mouse T cell clone, D10.G4.1, have been identified. Transient transfection assays