A genome-wide association study of survival in patients with sepsis

Autor: Tamara Hernandez-Beeftink, Beatriz Guillen-Guio, Jose M. Lorenzo-Salazar, Almudena Corrales, Eva Suarez-Pajes, Rui Feng, Luis A. Rubio-Rodríguez, Megan L. Paynton, Raquel Cruz, M. Isabel García-Laorden, Miryam Prieto-González, Aurelio Rodríguez-Pérez, Demetrio Carriedo, Jesús Blanco, Alfonso Ambrós, Elena González-Higueras, Elena Espinosa, Arturo Muriel, Eduardo Tamayo, María M. Martin, Leonardo Lorente, David Domínguez, Abelardo García de Lorenzo, Heather M. Giannini, John P. Reilly, Tiffanie K. Jones, José M. Añón, Marina Soro, Ángel Carracedo, Louise V. Wain, Nuala J. Meyer, Jesús Villar, Carlos Flores, the Genetics of Sepsis (GEN-SEP) Network

Publikováno v: Critical Care, Vol 26, Iss 1, Pp 1-10 (2022)

Abstract Background Sepsis is a severe systemic inflammatory response to infections that is accompanied by organ dysfunction and has a high mortality rate in adult intensive care units. Most genetic studies have identified gene variants associated wi

Externí odkaz: https://doaj.org/article/6a41f741af084c4dab8e4ca22baabbb6

The PANDORA Study: Prevalence and Outcome of Acute Hypoxemic Respiratory Failure in the Pre-COVID-19 Era

Autor: Jesús Villar, MD, PhD, FCCM, Juan M. Mora-Ordoñez, MD, Juan A. Soler, MD, PhD, Fernando Mosteiro, MD, PhD, Anxela Vidal, MD, Alfonso Ambrós, MD, PhD, Lorena Fernández, MD, Isabel Murcia, MD, Belén Civantos, MD, Miguel A. Romera, MD, Adrián Mira, MD, Francisco J. Díaz-Domínguez, MD, Dácil Parrilla, MD, J. Francisco Martínez-Carmona, MD, Domingo Martínez, MD, Lidia Pita-García, MD, Denis Robaglia, MD, Ana Bueno-González, MD, Jesús Sánchez-Ballesteros, MD, Ángel E. Pereyra, MD, Mónica Hernández, MD, Carlos Chamorro-Jambrina, MD, Pilar Cobeta, MD, Raúl I. González-Luengo, MD, Raquel Montiel, MD, Leonor Nogales, MD, M. Mar Fernández, MD, PhD, Blanca Arocas, MD, Álvaro Valverde-Montoro, MD, Ana M. del Saz-Ortiz, MD, Victoria Olea-Jiménez, MD, José M. Añón, MD, PhD, Pedro Rodríguez-Suárez, MD, Rosa L. Fernández, MSc, Cristina Fernández, MSc, Tamas Szakmany, MD, PhD, Jesús M. González-Martín, PhD, Carlos Ferrando, MD, PhD, Robert M. Kacmarek, PhD, RTT, Arthur S. Slutsky, MD, for the Prevalence AND Outcome of acute hypoxemic Respiratory fAilure (PANDORA) Network, José M. Añón, Belén Civantos, Mónica Hernández, Elena González, Rosario Solano, F. Javier Díaz-Domínguez, Demetrio Carriedo, Raul I. González Luengo, Carlos Ferrando, Blanca Arocas, Javier Belda, Marina Soro, Gerardo Aguilar, Ernesto Pastor, Lorena Fernández, Jesús Sánchez-Ballesteros, Arturo Muriel, Pablo Blanco-Schweizer, José Ángel de Ayala, Jesús Blanco, César Aldecoa, Alba Pérez, Jesús Rico-Feijoo, Leonor Nogales, David Andaluz, Laura Parra, Juan A. Soler, Domingo Martínez, Ana M. del Saz-Ortiz, Alfonso Ambrós, Ana Bueno-González, Carmen Hornos-López, Raquel Montiel, Dácil Parrilla, Eduardo Peinado, Isidro Prieto, Mario Chico, Miguel A. Romera, Carlos Chamorro-Jambrina, Juan M. Mora-Ordoñez, J. Francisco Martínez-Carmona, Álvaro Valverde-Montoro, Victoria Olea-Jiménez, Paco Alba, Ruth Corpas, Fernando Mosteiro, Lidia Pita-García, Eleuterio Merayo, Chanel Martínez, Ángeles de Célis-Álvarez, Carmen Martín-Delgado, Adrián Mira, Pilar Cobeta, David Pestaña, María del Mar Fernández, Concepción Tarancón, Silvia Cortés-Díaz, Anxela Vidal, Denis Robaglia, César Pérez, Isabel Murcia, Ángel E. Pereyra-Pache, Tamas Szakmany, Jesús Villar, Rosa L. Fernández, Cristina Fernández, Pedro Rodríguez-Pérez, Jesús M. González-Martín, Robert M. Kacmarek, Arthur S. Slutsky

Publikováno v: Critical Care Explorations, Vol 4, Iss 5, p e0684 (2022)

OBJECTIVES:. To establish the epidemiological characteristics, ventilator management, and outcomes in patients with acute hypoxemic respiratory failure (AHRF), with or without acute respiratory distress syndrome (ARDS), in the era of lung-protective

Externí odkaz: https://doaj.org/article/b683f9f5f7364cd08c59c3940ccadbd0

Whole-Blood Mitochondrial DNA Copies Are Associated With the Prognosis of Acute Respiratory Distress Syndrome After Sepsis

Autor: Tamara Hernández-Beeftink, Beatriz Guillen-Guio, Héctor Rodríguez-Pérez, Itahisa Marcelino-Rodríguez, Jose M. Lorenzo-Salazar, Almudena Corrales, Miryam Prieto-González, Aurelio Rodríguez-Pérez, Demetrio Carriedo, Jesús Blanco, Alfonso Ambrós, Elena González-Higueras, Nancy G. Casanova, Manuel González-Garay, Elena Espinosa, Arturo Muriel, David Domínguez, Abelardo García de Lorenzo, José M. Añón, Marina Soro, Javier Belda, Joe G. N. Garcia, Jesús Villar, Carlos Flores

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Acute respiratory distress syndrome (ARDS) is an inflammatory process of the lungs that develops primarily in response to pulmonary or systemic sepsis, resulting in a disproportionate death toll in intensive care units (ICUs). Given its role as a cri

Externí odkaz: https://doaj.org/article/a86e6e599596488c9563a8636f416698

Ventilator-induced diaphragm dysfunction: translational mechanisms lead to therapeutical alternatives in the critically ill

Autor: Oscar Peñuelas, Elena Keough, Lucía López-Rodríguez, Demetrio Carriedo, Gesly Gonçalves, Esther Barreiro, José Ángel Lorente

Publikováno v: Intensive Care Medicine Experimental, Vol 7, Iss S1, Pp 1-25 (2019)

Abstract Mechanical ventilation [MV] is a life-saving technique delivered to critically ill patients incapable of adequately ventilating and/or oxygenating due to respiratory or other disease processes. This necessarily invasive support however could

Externí odkaz: https://doaj.org/article/785c2cc546ab424798442da261c05a33

Pneumo-PET-CT: Initial Results of This Novel Technique on the Evaluation of Esophageal and Gastric Tumors with Anatomic-Surgical Correlation

Autor: Facundo N. Diaz, Marina Ulla, Jose M. Lastiri, Fernando G. Wright, Demetrio Cavadas

Publikováno v: Gastroenterology Research and Practice, Vol 2019 (2019)

We present the initial results of a novel hybrid scanning-based technique that combines pneumo-computed tomography (PNCT) with positron emission tomography (PET) using 2-(fluorine-18) fluoro-2-deoxy-D-glucose (FDG). We denominate it pneumo-PET-CT. Th

Externí odkaz: https://doaj.org/article/2171f440bc3948548525ee88702376b4