Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification

Autor: Yiyang Hu, Chunli Gong, Zhibin Li, Jiao Liu, Yang Chen, Yu Huang, Qiang Luo, Sumin Wang, Yu Hou, Shiming Yang, Yufeng Xiao

Publikováno v: Molecular Cancer, Vol 21, Iss 1, Pp 1-15 (2022)

Abstract Background Gastric cancer (GC) is one of the most pernicious tumors that seriously harm human healthcare. GC metastasis is one of the prime cause of failed cancer treatment, but correlation between N6-methyladenosine (m6A) and GC metastasis

Externí odkaz: https://doaj.org/article/b215d1c8b1e24e0dac3d32c2963fd364

A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities

Autor: Yuyi Ling, Hong-Sheng Wang, Shuibin Lin, Qin Peng, Guoyou Xie, Jiexin Li, Jiawang Zhou, Xu-Nian Wu, Zigang Li, Hai-Bin Luo, Yalan Rui, Deyan Wu

Publikováno v: Acta Pharmaceutica Sinica B. 12:853-866

N6-methyladenosine (m6A) modification is critical for mRNA splicing, nuclear export, stability and translation. Fat mass and obesity-associated protein (FTO), the first identified m6A demethylase, is critical for cancer progression. Herein, we develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64dc7b2f137229a58fff2f065c26f9ef
https://doi.org/10.1016/j.apsb.2021.08.028

Nuclear S-nitrosylation impacts tissue regeneration in zebrafish

Autor: Hon-Chiu Eastwood Leung, Gianfranco Matrone, Antrix Jain, Martin A. Denvir, John P. Cooke, Julie Rodor, Cristian Coarfa, Sung Yun Jung, Jong Min Choi, Kimal Rajapakshe, Andy Baker

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Matrone, G, Jung, S Y, Choi, J M, Jain, A, Eastwood Leung, H-C, Rajapakshe, K, Coarfa, C, Rodor, J, Denvir, M A, Baker, A H & Cooke, J P 2021, ' Nuclear S-nitrosylation impacts tissue regeneration in zebrafish ', Nature Communications . https://doi.org/10.1038/s41467-021-26621-0

Despite the importance of nitric oxide signaling in multiple biological processes, its role in tissue regeneration remains largely unexplored. Here, we provide evidence that inducible nitric oxide synthase (iNos) translocates to the nucleus during ze

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89522bea17de6a4bf80d341b7eda9310
https://doaj.org/article/adfe028e44264c2b8db2eceb6959bc23

UTX condensation underlies its tumour-suppressive activity

Autor: Enrico Gratton, David Dimoff, Aleksandra Ulman, Chongzhi Zang, John Philip Le, Yansu Song, William Jarrard, Wei Li, Rui Ju, Zhenjia Wang, Hao Jiang, Michelle A. Digman, Bi Shi, Jing Hu, Yanfang Zhao, Francesco Palomba

Publikováno v: Nature. 597:726-731

UTX (also known as KDM6A) encodes a histone H3K27 demethylase and is an important tumour suppressor that is frequently mutated in human cancers1. However, as the demethylase activity of UTX is often dispensable for mediating tumour suppression and de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e098450fe2ae44f89b84038cf98d21f9
https://doi.org/10.1038/s41586-021-03903-7

Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis

Autor: Jie Xiong, Jiachen Fan, Fan Wang, Yan Lin, Feng Li, Yurou Chen, Yulong Qiang, Xin Zhou, Jing Guo, Haihua Xue, Pengfei Li, Qian Zheng

Publikováno v: Theranostics

Background: Clear cell renal cell carcinoma (ccRCC) is characterized by glycogen-laden, unexplained male predominance, and frequent mutations in the Von Hippel-Lindau (VHL) gene and histone modifier genes. Besides, poor survival rates of ccRCC patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6e9ef25915ef9100753f416e71f167
http://europepmc.org/articles/PMC8419058