Výsledky vyhledávání - "Demet Sinem Guden"

mTOR inhibition as a possible pharmacological target in the management of systemic inflammatory response and associated neuroinflammation by lipopolysaccharide challenge in rats

Autor: Deniz Kibar, Meryem Temiz-Resitoglu, Demet Sinem Guden, Şakir Necat Yılmaz, Kafait U. Malik, Sefika Pinar Senol, Seyhan Sahan-Firat, Bahar Tunctan

Publikováno v: Canadian Journal of Physiology and Pharmacology. 99:921-934

Neuroinflammation plays a critical role during sepsis triggered by microglial activation. Mammalian target of rapamycin (mTOR) has gained attraction in neuroinflammation, however, the mechanism remains unclear. Our goal was to assess the effects of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b13f7469fbe44a26ebdf034f6edf4f9
https://doi.org/10.1139/cjpp-2020-0487

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C-reactive protein as a potential biomarker in psychiatric practice: Are we there yet?

Autor: Erensu Baysak, Feyza Aricioglu, Demet Sinem Guden, Angelos Halaris

Publikováno v: The World Journal of Biological Psychiatry. 23:243-256

Objectives: Serum or plasma levels of C-reactive protein (CRP) and highsensitivity CRP (hsCRP) are widely used clinical markers of inflammation in other branches of medicine, whereas its clinical use in psychiatry has been limited to research studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6dbffc0acec8e0372862b5beae6ead9
https://doi.org/10.1080/15622975.2021.1961502

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Soluble epoxide hydrolase inhibitor trifluoromethoxyphenyl‐3‐(1‐propionylpiperidin‐4‐yl)urea prevents hyperalgesia through regulating NLRC4 inflammasome‐related pro‐inflammatory and anti‐inflammatory signaling pathways in the lipopolysaccharide‐induced pain mouse model

Autor: Seyhan Sahan-Firat, Ali Cagli, Sefika Pinar Senol, Meryem Temiz-Resitoglu, Bahar Tunctan, Ayse Nihal Sari, Demet Sinem Guden

Publikováno v: Drug Development Research. 82:815-825

Epoxyeicosatrienoic acids (EETs) have anti-inflammatory effects and soluble epoxide hydrolase (sEH) inhibition might be a useful therapeutic approach to manage inflammatory disorders. The purpose of the study was to investigate whether nucleotide-bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d45be6a2feb52e9d6be516661c71a72
https://doi.org/10.1002/ddr.21786

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Suppression of TLR4/MyD88/TAK1/NF-κB/COX-2 Signaling Pathway in the Central Nervous System by Bexarotene, a Selective RXR Agonist, Prevents Hyperalgesia in the Lipopolysaccharide-Induced Pain Mouse Model

Autor: Meryem Temiz-Resitoglu, Seyhan Sahan-Firat, Sefika Pinar Senol, Demet Sinem Guden, Ayse Nihal Sari, Bahar Tunctan

Publikováno v: Neurochemical Research. 46:624-637

A selective RXR agonist, bexarotene, has been shown to have anti-inflammatory, anti-nociceptive, and neuroprotective effects in several models of numerous neurological diseases characterized by systemic inflammation. The mechanisms underlying these e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1fa0bb65e17f1828235b1c72b3804d
https://doi.org/10.1007/s11064-020-03197-7

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An Overview of Experimental Models on Ischemic Heart Diseases

Autor: Demet Sinem Guden, Ahmet Ozer Sehirli

Publikováno v: Volume: 9, Issue: 4 358-365
Clinical and Experimental Health Sciences

Objective: Heart failure is commonly defined as a heart dysfunction associated with pulmonary alveolar blood flow and consequent inability to ensure adequate blood supply to the tissues or to meet the body’s metabolic demand. Currently, there is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e16fd0e8478306ed2c0e1af2a92e874
https://doi.org/10.33808/clinexphealthsci.598928

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Modulation of oxidative–nitrosative stress and inflammatory response by rapamycin in target and distant organs in rats exposed to hindlimb ischemia–reperfusion: the role of mammalian target of rapamycin

Autor: Seyhan Sahan-Firat, Senay Balci, Özden Vezir, Lulufer Tamer-Gumus, Bahar Tunctan, Meryem Temiz-Resitoglu, Kafait U. Malik, Zumrut Kocak, Demet Sinem Guden, Nehir Sucu

Publikováno v: Canadian Journal of Physiology and Pharmacology. 97:1193-1203

Mammalian target of rapamycin (mTOR) has been recognized with potential immunomodulatory properties playing an important role in various physiopathological processes including ischemia–reperfusion (I/R) injury. I/R injury stimulate reactive oxygen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac436769f8ee2eab3293a06a07ba755e
https://doi.org/10.1139/cjpp-2019-0394

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Activation of GPR75 Signaling Pathway Contributes to the Effect of a 20-HETE Mimetic, 5,14-HEDGE, to Prevent Hypotensive and Tachycardic Responses to Lipopolysaccharide in a Rat Model of Septic Shock

Autor: Bahar Tunctan, Sefika Pinar Senol, Meryem Temiz-Resitoglu, Dilsah Ezgi Yilmaz, Demet Sinem Guden, Omer Bahceli, Mehmet Furkan Horat, Seyhan Sahan-Firat, Ayse Nihal Sari, John R. Falck, Raghunath Reddy Anugu, Kafait U. Malik

Publikováno v: Journal of cardiovascular pharmacology. 80(2)

The orphan receptor, G protein-coupled receptor (GPR) 75, which has been shown to mediate various effects of 20-hydroxyeicosatetraenoic acid (20-HETE), is considered as a therapeutic target in the treatment of cardiovascular diseases in which changes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e7a8caeece3d61696c612a8e6217c7
https://pubmed.ncbi.nlm.nih.gov/35575984

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Pharmacological Inhibition of Mammalian Target of Rapamycin Attenuates Deoxycorticosterone Acetate Salt-Induced Hypertension and Related Pathophysiology: Regulation of Oxidative Stress, Inflammation, and Cardiovascular Hypertrophy in Male Rats

Autor: Şakir Necat Yılmaz, Özden Vezir, Deniz Kibar, Nehir Sucu, Meryem Temiz-Resitoglu, Bahar Tunctan, Seyhan Sahan-Firat, Sefika Pinar Senol, Demet Sinem Guden, Kafait U. Malik

Publikováno v: Journal of cardiovascular pharmacology. 79(3)

The present study aimed to explore the contribution of mammalian target of rapamycin (mTOR) in deoxycorticosterone acetate (DOCA) salt-induced hypertension and related pathophysiological changes in cardiovascular and renal tissues. DOCA salt loading

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf834a7710d9df65fc09d10ecb732483
https://pubmed.ncbi.nlm.nih.gov/34840266

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Involvement of Rho-kinase/IκB-α/NF-κB activation in IL-1β-induced inflammatory response and oxidative stress in human chondrocytes

Autor: Rukiye Nalan Tiftik, Demet Sinem Guden, İsmail Ün, Meryem Temiz-Resitoglu, Şakir Necat Yılmaz, Gülsen Bayrak, Seyhan Sahan-Firat

Publikováno v: Canadian journal of physiology and pharmacology. 99(4)

It has been clearly indicated that osteoarthritis (OA) is an inflammatory and degenerative disease that could be promoted by Rho-kinase (ROCK); however, little is known about the role of ROCK/inhibitor κB alpha (IκB-α)/nuclear factor-κB (NF-κB)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ba931e2fd3aa2b64c82fb3c32837e1
https://pubmed.ncbi.nlm.nih.gov/33769089

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Soluble epoxide hydrolase inhibitor trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea prevents hyperalgesia through regulating NLRC4 inflammasome-related pro-inflammatory and anti-inflammatory signaling pathways in the lipopolysaccharide-induced pain mouse model

Autor: Ali, Cagli, Sefika Pinar, Senol, Meryem, Temiz-Resitoglu, Demet Sinem, Guden, Ayse Nihal, Sari, Seyhan, Sahan-Firat, Bahar, Tunctan

Publikováno v: Drug development researchREFERENCES. 82(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c43497d064b3dfeb0816bcc57e095878
https://pubmed.ncbi.nlm.nih.gov/33559150

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