Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Demet Araç"'
Autor:
Szymon P. Kordon, Przemysław Dutka, Justyna M. Adamska, Sumit J. Bandekar, Katherine Leon, Satchal K. Erramilli, Brock Adams, Jingxian Li, Anthony A. Kossiakoff, Demet Araç
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Adhesion GPCRs have numerous functions, ligands and isoforms. Here, Kordon et al. report synthetic antibodies that both modulate aGPCR signaling in an isoform-specific manner, and break receptor interactions in a ligand-specific manner
Externí odkaz:
https://doaj.org/article/f09e75b26ec2499fb1db91e3ee673ec0
Autor:
Duy Lan Huong Bui, Andrew Roach, Jingxian Li, Sumit J. Bandekar, Elizabeth Orput, Ritika Raghavan, Demet Araç, Richard C. Sando
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112552- (2023)
Summary: Adhesion G protein-coupled receptors (aGPCRs) are a large GPCR class that direct diverse fundamental biological processes. One prominent mechanism for aGPCR agonism involves autoproteolytic cleavage, which generates an activating, membrane-p
Externí odkaz:
https://doaj.org/article/8f4a596913f5446cb1c98429a2c5beec
Autor:
Jingxian Li, Yuan Xie, Shaleeka Cornelius, Xian Jiang, Richard Sando, Szymon P. Kordon, Man Pan, Katherine Leon, Thomas C. Südhof, Minglei Zhao, Demet Araç
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The trans-synaptic interaction of the cell-adhesion molecules teneurins (TENs) with latrophilins (LPHNs) promotes excitatory synapse formation. Here authors report the high resolution cryo-EM structure of the TEN2-LPHN3 complex, describe the trimeric
Externí odkaz:
https://doaj.org/article/40b62dc45fba43818c436bb498569426
Autor:
Katherine Leon, Rebecca L. Cunningham, Joshua A. Riback, Ezra Feldman, Jingxian Li, Tobin R. Sosnick, Minglei Zhao, Kelly R. Monk, Demet Araç
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The extracellular regions (ECRs) of adhesion GPCRs have diverse biological functions, but their structures and mechanisms of action remain unclear. Here, the authors solve the ECR structure of the Gpr126 receptor and show that ECR conformation and si
Externí odkaz:
https://doaj.org/article/e5359c615ebc4086814c00727386b7d8
Autor:
Olha Nazarko, Amanuel Kibrom, Jana Winkler, Katherine Leon, Hannah Stoveken, Gabriel Salzman, Katarzyna Merdas, Yue Lu, Pradnya Narkhede, Gregory Tall, Simone Prömel, Demet Araç
Publikováno v:
iScience, Vol 3, Iss , Pp 264-278 (2018)
Summary: Adhesion G-protein-coupled receptors (aGPCRs) play critical roles in diverse cellular processes in neurobiology, development, immunity, and numerous diseases. The lack of molecular understanding of their activation mechanisms, especially wit
Externí odkaz:
https://doaj.org/article/c0d06d0ca51c4aa8ac4d123df30ea9d5
Autor:
Pavol Skubák, Demet Araç, Matthew W. Bowler, Ana R. Correia, Andre Hoelz, Sine Larsen, Gordon A. Leonard, Andrew A. McCarthy, Sean McSweeney, Christoph Mueller-Dieckmann, Harm Otten, Gabriel Salzman, Navraj S. Pannu
Publikováno v:
IUCrJ, Vol 5, Iss 2, Pp 166-171 (2018)
Determining macromolecular structures from X-ray data with resolution worse than 3 Å remains a challenge. Even if a related starting model is available, its incompleteness or its bias together with a low observation-to-parameter ratio can render the
Externí odkaz:
https://doaj.org/article/cd905f578c934c5998ab5f7a1c85b02e
Autor:
Demet Araç, Jingxian Li
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Teneurins are a conserved family of cell-surface adhesion molecules that mediate cellular communication, and play key roles in embryonic and neural development. Their mechanisms of action remained unclear due in part to their unknown structures. In r
Externí odkaz:
https://doaj.org/article/713587649d9443fb8154e9bb3528dd3a
Autor:
Rong Luo, Sung-Jin Jeong, Annie Yang, Miaoyun Wen, David E Saslowsky, Wayne I Lencer, Demet Araç, Xianhua Piao
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100043 (2014)
GPR56 is a member of the adhesion G protein-coupled receptor (GPCR) family. Despite the importance of GPR56 in brain development, where mutations cause a devastating human brain malformation called bilateral frontoparietal polymicrogyria (BFPP), the
Externí odkaz:
https://doaj.org/article/e93ded8dd5b84aa4990bdcd2b3c1e736
Publikováno v:
EMBO reports.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da7f49a75eea0b9f664b8c711c040139
https://doi.org/10.15252/embr.202256728
https://doi.org/10.15252/embr.202256728
Autor:
Gabriel Carmona-Rosas, Jingxian Li, Jayson J. Smith, Shouqiang Cheng, Elana Baltrusaitis, Wioletta I. Nawrocka, Minglei Zhao, Paschalis Kratsios, Demet Araç, Engin Özkan
Latrophilins/ADGRLs are conserved adhesion-type G protein-coupled receptors associated with early embryonic morphogenesis defects, lethality, and sterility across multiple model organisms. However, their mechanistic roles in embryogenesis and the ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b129bef6e85ca5650a4e4d3d07dbdfee
https://doi.org/10.1101/2023.05.04.539414
https://doi.org/10.1101/2023.05.04.539414
